The anti-Ras cancer drug MKT-077 is an F-actin cross-linker

Annals of the New York Academy of Sciences

Volumn 886, Issue , 1999, Pages 283-284

  Maruta, Hiroshi ^a   Tikoo, Anjali ^a   Shakri, Rushdi ^a   Shishido, Tadao ^b  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^b FUJIFILM CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 ETHYL 2 [[3 ETHYL 5 (3 METHYLBENZOTHIAZOLIN 2 YLIDENE) 4 OXOTHIAZOLIDIN 2 YLIDENE]METHYL]PYRIDINIUM CHLORIDE; ANTINEOPLASTIC AGENT; F ACTIN; RAS PROTEIN;

ANIMAL CELL; CELL STRAIN 3T3; CONFERENCE PAPER; CROSS LINKING; DRUG CYTOTOXICITY; MOUSE; MUTANT; NONHUMAN; ONCOGENE RAS;

ANIMALIA;

EID: 0033451825     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb09437.x     Document Type: Conference Paper

References (6)

1. 1. Koya, K., Y. Li, H. Wang, T. Ukai, N. Tatsuta, M. Kawakami, T. Shishido & L.B. Chen. 1996. MKT-077, a novel rhodacyanine dye in clinical trials, exhibits anticarcinoma activity in preclinical studies based on selective mitochondrial accumulation. Cancer Res. 56: 538-543.
2. 2. Kawakami, M., N. Suzuki, Y. Sudo, T. Shishido & M. Maeda. 1998. Development of an enzyme-linked immunosorbent assay (ELISA) for antitumor agent MKT-077. Anal. Chim. Acta 362: 177-186.
3. 3. He, H., T. Watanabe, X. Zhan, C. Huang, E. Schuuring, K. Fukami, T. Takenawa, C.C. Kumar, S.J. Simpson & H. Maruta. 1998. Role of PIP2 in Ras/Rac-induced disruption of the cortactin-actomyosin II complex and malignant transformation. Mol. Cell Biol. 18: 3829-3837.
4. 4. Fernandez, J.L.R., B. Geiger, D. Salomon, I. Sabanay, M. Zoeller & A. Ben-Ze'ev. 1992. Suppression of tumorigenicity in SV40-transformed cells after transfection with vinculin cDNA. J. Cell Biol. 119: 427-438.
5. 5. Glueck, U., D. Kwiatkowski & A. Ben-Ze'ev. 1993. Suppression of tumorigenicity in SV40-transformed 3T3 cells transfected with alpha-actinin cDNA. Proc. Natl. Acad. Sci. USA 90: 383-387.
6. 6. Maruta, H., A. Tikoo, R. Shakri, L. Zugaro, Y. Hirokawa, T. Shishido, B. Bowers, L.H. Ye, K. Kohama & R. Simpson. 1999. The anti-cancer drug MKT-077 cross-links actin filaments and binds HSC70 chaperone ATPase in v-Ha-Ras transformants. Cancer Res. 59. In press.