Role of TNF-α in high-dose antigen therapy in experimental autoimmune neuritis: Inhibition of TNF-α by neutralizing antibodies reduces T-cell apoptosis and prevents liver necrosis

Journal of Neuropathology and Experimental Neurology

Volumn 59, Issue 5, 2000, Pages 368-376

  Weishaupt, Andreas ^b   Gold, Ralf ^a   Hartung, Thomas ^b   Gaupp, Stefanie ^a   Wendel, Albrecht ^b   Brück, Wolfgang ^c   Toyka, Klaus V ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Apoptosis; Experimental autoimmune neuritis; Immunotherapy; T lymphocytes

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DEMYELINATION; FEMALE; LIVER NECROSIS; NEURITIS; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE;

EID: 0034098114     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/59.5.368     Document Type: Article

References (38)

1. Hartung HP, Gold R, Jung S. Local immune responses in the peripheral nervous system. In: Antel J, Birnbaum G, Hartung H-P, eds. Clinical neuroimmunology 1998:40-54
2. Kadlubowski M, Hughes RAC. Identification of the neuritogen for experimental allergic neuritis. Nature 1979;277:140-41
3. Brostoff SW, Levit S, Powers JM. Induction of experimental allergic neuritis with a peptide from myelin P2 basic protein. Nature 1977;268:752-53
4. Weishaupt A, Giegerich G, Jung S, et al. T cell antigenic and neuritogenic activity of recombinant human peripheral myelin P2 protein. J Neuroimmunol 1995;63:149-56
5. Linington C, Izumo S, Suzuki M, Uyemura K, Meyermann R, Wekerle H. A permanent rat T cell line that mediates experimental allergic neuritis in the Lewis rat in vivo. J Immunol 1984;133:1946-50
6. Suzuki G, Kawase Y, Koyasu S, Yahara I, Kobayashi Y, Schwartz RH. Antigen-induced suppression of the proliferation response of T cell clones. J Immunol 1988;140:1359-65
7. Critchfield JM, Racke MK, Zuniga-Pflücker JC, et al. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science 1994;263:1139-43
8. Weishaupt A, Gold R, Gaupp S, Giegerich G, Hartung HP, Toyka KV. Antigen therapy eliminates T cell inflammation by apoptosis: Effective treatment of experimental autoimmune neuritis with recombinant myelin protein P2. Proc Natl Acad Sci USA 1997;94: 1338-43
9. Liblau RS, Tisch R, Bercoivici N, McDevitt HO. Systemic antigen in the treatment of T-cell-mediated autoimmune diseases. Immunol Today 1997;8:599-604
10. McFarland HI, Critchfield JM, Racke MK, et al. Amelioration of autoimmune reactions by antigen-induced apoptosis of T cells. Immunobiology of Proteins and Peptides. 1995;VIII:157-66
11. Liblau RS, Tisch R, Shokat K, et al. Intravenous injection of soluble antigen induces thymic and peripheral T-cell apoptosis. Proc Natl Acad Sci USA 1996;93:3031-36
12. Nagata S, Golstein P. The Fas death factor. Science 1995;267: 1449-56
13. Suda T, Nagata S. Purification and characterization of the Fas-ligand that induces apoptosis. J Exp Med 1994;179:873-79
14. Tartaglia LA, Rothe M, Hu YF, Goeddel DV. Tumor necrosis lactor's cytotoxic activity is signaled by the p55 TNF receptor. Cell 1993;73:213-16
15. Galle PR, Hofmann WJ, Walczak H, et al. Involvement of the CD95 (Apo-1/Fas) receptor and ligand in liver damage. J Exp Med 1995;182:1223-30
16. Leist M, Gantner F, Jilg S, Wendel A. Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release. J Immunol 1996;154: 1307-16
17. Jones AL, Selby P. Tumour necrosis factor: Clinical relevance. Cancer Surv 1989;8:817-36
18. Leist M, Gantner F, Bohlinger PG, Tiegs G, Wendel A. Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-α requires transcriptional arrest. J Immunol 1994;153:1778-88
19. Stienekemeier M, Herrmann T, Kruse N, et al. Heterogeneity of T-cell receptor usage in experimental autoimmune neuritis in the Lewis rat. Brain 1999;122:523-35
20. Barsig J, Küsters S, Vogt K, Volk HD, Tiegs G, Wendel A. Lipopolysaccharide-induced interleukin-10 in mice: Role of endogenous tumor necrosis factor-α. Eur J Immunol 1995;25:2888-93
21. Hartung T, Wendel A. Endotoxin-inducible cytotoxicity in liver cell cultures-I. Biochem Pharmacol 1991;42:1129-35
22. Zettl UK, Gold R, Toyka KV, Hartung HP. Intravenous glucocorticosteroid treatment augments apoptosis of inflammatory T cells in experimental autoimmune neuritis (EAN) of the Lewis rat. J Neuropathol Exp Neurol 1995;54:540-47
23. King RHM, Craggs RI, Cross MLP, Thomas PK. Effects of glucocorticoids on experimental allergic neuritis. Exp Neurol 1985;87: 9-19
24. Hartung HP, Schäfer B, Heininger K, Stoll G, Toyka KV. The role of macrophages and eicosanoids in the pathogenesis of experimental allergic neuritis. Serial clinical, electrophysiological, biochemical and morphological observations. Brain 1988;111:1039-59
25. Bergmeyer HU. Methods of enzymatic analysis. 3rd Ed. Verlag Chemie Weinheim, 1984;Vol. 82
26. Hünig T, Wallny HJ, Hartley JK, Lawetzky A, Tiefenthaler G. A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation: Differential reactivity with subsets of immature and mature T lymphocytes. J Exp Med 1989;169:73-86
27. Gold R, Schmied M, Giegerich G, et al. Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation technique. Lab Invest 1994;71:219-25
28. Cross AH, Cannella B, Brosnan CF, Raine CS. Homing to central nervous system vasculature by antigen-specific lymphocytes. Lab Invest 1990;63:162-70
29. Cope AP, Liblau RS, Yang XD, et al. Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signalling. J Exp Med 1997;185:1573-84
30. Liu J, Marino W, Wong G, et al. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nature Med 1998;4:78-83
31. Eugster HP, Frei K, Bachmann R, Bluethmann H, Lassmann H, Fontana A. Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1. Eur J Immunol 1999;29:626-32
32. Stoll G, Jung S, Jander S, Van der Meide P, Hartung HP. Tumor necrosis factor-alpha in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system. J Neuroimmunol 1993;45:175-82
33. Ruddle NH, Bergman CM, McGrath KM, et al. An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. J Exp Med 1990;172:1193-2000
34. Körner H, Lemckert FA, Chaudhri G, Etteldorf S, Sedgwick JD. Tumor necrosis factor blockade in actively induced experimental autoimmune encephalomyelitis prevents clinical disease despite activated T cell infiltration to the central nervous system. Eur J Immunol 1997;27:1973-81
35. Baker D, Butler D, Scallon BJ, O'Neill JK, Turk JL, Feldmann M. Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins. Eur J Immunol 1994;24:2040-48
36. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group. TNF neutralization in MS: Results of a randomized, placebo-controlled multicenter study. Neurology 1999;53:457-65
37. Vergelli M, Hemmer B, Utz U, et al. Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87-99). Eur J Immunol 1996;11: 2624-34
38. Kjellen P, Issazadeh S, Olsson T, Holmdahl R. Genetic influence on disease course and cytokine response in relapsing experimental allergic encephalomyelitis. Int Immunol 1998;10:333-40