Role of chromatin structure and distal enhancers in tissue-specific transcriptional regulation in vitro

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 63, Issue , 1998, Pages 569-576

  Bagga, R ^a   Armstrong, J A ^a   Emerson, B M ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBULIN; DNA BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; ERYTHROID KRUPPEL LIKE FACTOR; HEMOGLOBIN BETA CHAIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR NF E2;

ANIMAL CELL; CHROMATIN STRUCTURE; COMPLEX FORMATION; CONFERENCE PAPER; DNA PACKAGING; ENHANCER REGION; ERYTHROID CELL; GENE EXPRESSION REGULATION; GENE LOCUS; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN STRUCTURE; REGULATOR GENE; REPORTER GENE; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION; CELL CYCLE PROGRESSION; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA RECOMBINATION; DNA REPLICATION; DNA STRUCTURE; GENE CONTROL; GENE EXPRESSION; HUMAN; INSULATOR ELEMENT; PROTEIN PROCESSING; SILENCER ELEMENT;

EID: 0032459210     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1998.63.569     Document Type: Conference Paper

References (48)

1. Aki T. and Adhya S. 1997. Repressor induced site-specific binding of HU for transcriptional regulation. EMBO J. 16: 3666.
2. Andrews N.C., Erdjument-Bromage H., Davidson M.B., Tempst P., and Orkin S.H. 1993a. Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-Ieucine zipper protein. Nature 362: 722.
3. Andrews N.C., Kotkow K.J., Ney P.A., Erdjument-Bromage H., Tempst P., and Orkin S.H. 1993b. The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc. Natl. Acad. Sci. 90: 11488.
4. Armstrong J.A. and Emerson B.M. 1996. NF-E2 disrupts chromatin structure at human β-globin locus control region hypersensitive site 2 in vitro. Mol. Cell. Biol. 16: 5634.
5. _. 1998. Transcription of chromatin: These are complex times. Curr. Opin. Genet. Dev. 8: 165.
6. Bagga R. and Emerson B.M. 1997. An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro. Genes Dev. 11: 629.
7. Barton M.C. and Emerson B.M. 1994. Regulated expression of the β-globin gene locus in synthetic nuclei. Genes Dev. 8: 2453.
8. Barton M.C., Madani N., and Emerson B.M. 1993. The erythroid protein cGATA-1 functions with a stage-specific factor to activate transcription of chromatin-assembled β-globin genes. Genes Dev. 7: 1796.
9. _. 1997. Distal enhancer regulation by promoter derepression in topologically constrained DNA in vitro. Proc. Natl. Acad. Sci. 94: 7257.
10. Bieker J.J. and Southwood C.M. 1995. The erythroid Krüppel-like factor transactivation domain is a critical component for cell-specific inducibility of the β-globin promoter. Mol. Cell. Biol. 15: 852.
11. Bulger M. and Kadonaga J.T. 1994. Biochemical reconstitution of chromatin with physiological nucleosome spacing. Methods Mol. Genet. 5: 241.
12. Bustin M. and Reeves R. 1996. High-mobility-group chromosomal proteins: Architectural components that facilitate chromatin function. Prog. Nucleic Acid Res. Mol. Biol. 54: 35.
13. Cairns B.R. 1998. Chromatin-remodeling machines: Similar motors, ulterior motives. Trends Biochem. Sci. 23: 20.
14. Capone M., Watrin F., Fernex C., Horvat B., Krippl B., Wu L., Scollay R., and Ferrier P. 1993. TCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity on V(D)J recombination events. EMBO J. 12: 4335.
15. Crossley M., Whitelaw E., Perkins A., Williams G., Fujiwara Y., and Orkin S.H. 1996. Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells. Mol. Cell. Biol. 16: 1695.
16. Davie J.R. 1998. Covalent modifications of histones: Expression from chromatin templates. Curr. Opin. Genet. Dev. 8: 173.
17. Duncan R., Bazar L., Michelotti G., Tomonaga T., Krutzsch H., Avigan M., and Levens D. 1994. A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif. Genes Dev. 8: 465.
18. Feng W.C., Southwood C.M., and Bieker J.J. 1994. Analyses of beta-thalassemia mutant DNA interactions with erythroid Krüppel-like factor (EKLF), an erythroid cell-specific transcription factor. J. Biol. Chem. 269: 1493.
19. Forrester W.C., Epner E., Driscoll M.C., Enver T., Brice M., Papayannopoulou T., and Groudine M. 1990. A deletion of the human β-globin locus control region causes a major alteration in chromatin structure and replication across the entire β-globin gene locus. Genes Dev. 4: 1637.
20. Giese K., Kingsley C., Kirschner J.R., and Grosschedl R. 1995. Assembly and function of a TCRα enhancer complex is dependent on LEF-1 induced DNA bending and multiple protein-protein interactions. Genes Dev. 9: 995.
21. Grosveld F., Assendelft G.B.V., Greaves D., and Kollias G. 1987. Position-independent, high-level expression of the human β-globin gene in transgenic mice. Cell 51: 975.
22. Groudine M., Kohwi-Shigematsu T., Gelinas R., Stamatoy-annopoulos G., and Papayannopoulou T. 1983. Human fetal to adult hemoglobin switching: Changes in chromatin structure of the β-globin gene locus. Proc. Natl. Acad. Sci. 80: 7551.
23. Kadonaga J.T. 1998. Eukaryotic transcription: An interlaced network of transcription factors and chromatin-modifying machines. Cell 92: 307.
24. Kim T.K. and Maniatis T. 1997. The mechanism of transcriptional synergy of an in vitro assembled interferon-β enhanceosome. Mol. Cell 1: 119.
25. Leiden J.M. 1993. Transcriptional regulation of T-cell receptor genes. Annu. Rev. Immunol. 11: 539.
26. Majumder S., Miranda M., and DePamphilis M.L. 1993. Analysis of gene expression in mouse preimplantation embryos demonstrates that the primary role of enhancers is to relieve repression of promoters. EMBO J. 12: 1131.
27. Martin D.I.K., Fiering S., and Groudine M. 1996. Regulation of β-globin gene expression: Straightening out the locus. Curr. Opin. Genet. Dev. 6: 488.
28. Merika M., Williams A.J., Chen G., Collins T., and Thanos D. 1998. Recruitment of CBP/p300 by the IFNβ enhanceosome is required for synergistic activation of transcription. Mol. Cell 1: 277.
29. Miller I.J. and Bieker J.J. 1993. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear protetins. Mol. Cell. Biol. 3: 2776.
30. Ner S.S., Travers A.A., and Churchill M.E. 1994. Harnessing the writhe: A role for DNA chaperones in nucleoprotein-complex formation. Trends Biochem. Sci. 19: 185.
31. Ney P., Sorrentino B.P., McDonagh K.T., and Nienhuis A.W. 1990. Tandem AP-1-binding sites within the human β-globin dominant control region function as an inducible enhancer in erythroid cells. Genes Dev. 4: 993.
32. Nuez B., Michalovich D., Bygrave A., Ploemacher R., and Grosveld F. 1995. Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature 375: 316.
33. Orkin S.H. 1995. Regulation of globin gene expression in erythroid cells. Eur. J. Biochem. 231: 271.
34. Perkins A.C., Sharpe A.H., and Orkin S.H. 1995. Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature 375: 318.
35. Ptashne M. 1986. Gene regulation by proteins acting nearby and at a distance. Nature 322: 697.
36. Rippe K., von Hippel P.M., and Langowski J. 1995. Action at a distance: DNA-looping and initiation of transcription. Trends Biochem. Sci. 20: 500.
37. Stamatoyannopoulos G. and Nienhuis A. 1994. Hemoglobin switching. In The molecular basis of blood diseases (ed. G. Stamatoyannopoulos), p. 107. W.B. Saunders, Philadelphia.
38. Starck J., Sarkar R., Romana M., Bhargava A., Scarpa A.L., Tanaka M., Chamberlain J.W., Weissman S.M., and Forget B.G. 1994. Developmental regulation of human γ- and βglobin genes in the absence of the locus control region. Blood 8-4: 1656.
39. Talbot D. and Grosveld F. 1991. The 5′HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites. EMBO J. 10: 1391.
40. Tewari R., Gillemans N., Wijgerde M., Nuez B., von Lindern M., Grosveld F., and Philipsen S. 1998. Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5′HS3 of the β-globin locus control region. EMBO J. 17: 2334.
41. Thanos D. and Maniatis T. 1995. Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell 83: 1091.
42. Tuan D., Solomon W., Li Q., and London I.M. 1985. The β-like-globin gene domain in human erythroid cells. Proc. Natl. Acad. Sci. 82: 6384.
43. Walters M.C., Fiering S. Eidemiller J., Magis W., Groudine M., and Martin D.I. 1995. Enhancers increase the probability but not the level of gene expression. Proc. Natl. Acad. Sci. 92: 7125.
44. Wang W., Xue Y., Zhou S., Kuo A., Cairns B.R., and Crabtree G.R. 1996a. Diversity and specialization of mammalian SWI/SNF complexes. Genes Dev. 10: 2117.
45. Wang W., Côté J., Xue Y., Zhou S., Khavari P.A., Biggar S.R., Muchardt C., Kalpana G.V., Goff S.P., Yaniv M., and Workman J.L. 1996b. Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. EMBO J. 15: 5370.
46. Waterman M.L., Fischer W.H., and Jones K.A. 1991. A thymus-specific member of the HMG protein family regulates the human T-cell receptor Cα enhancer. Genes Dev. 5: 656.
47. Wijgerde M., Gribnau J., Trimborn T., Nuez B., Philipsen S., Grosveld F., and Fraser P. 1996. The role of EKLF in human β-globin gene competition. Genes Dev. 10: 2894.
48. Yang Y., Westcott T.P., Pedersen S.C., Tobias I., and Olson W.K. 1995. Effects of localized bending on DNA supercoiling. Trends Biochem. Sci. 20: 313.