The murine Otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus

Developmental Biology

Volumn 227, Issue 2, 2000, Pages 432-449

  Wang, Weidong ^a   Lufkin, Thomas ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

CNS patterning; Embryo; Homeobox; Hypothalamus; Neuroendocrine; Pituitary

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL LINEAGE; CELL LOSS; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; GENE CONTROL; GENE EXPRESSION; GENE INACTIVATION; HOMEOBOX; HYPOTHALAMUS; MOUSE; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALIA; MURINAE;

EID: 0034669078     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2000.9902     Document Type: Article

References (30)

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3. Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of down syndrome
4. Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila
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7. Differential expression of corticotropin-releasing hormone in developing mouse embryos and adult brain
8. Gsh-1, an orphan Hox gene, is required for normal pituitary development
9. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1
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11. Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP)
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14. The POU domain transcription factor Brn-2 is required for the determination of specific neuronal lineages in the hypothalamus of the mouse
15. Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development
16. Targeted mutagenesis of the POU-domain gene Brn4/Pou3f4 causes developmental defects in the inner ear
17. Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2
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24. P-OTX: A PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development
25. Molecular cloning, chromosomal mapping and developmental expression of BAPX1, a novel human homeobox-containing gene homologous to Drosophila bagpipe
26. The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen
27. A planarian orthopedia homolog is specifically expressed in the branch region of both the mature and regenerating brain
28. Otp maps to mouse Chromosome 13
29. Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene
30. Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues