Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene

Genes and Development

Volumn 13, Issue 21, 1999, Pages 2787-2800

  Acampora, Dario ^a   Postiglione, Maria Pia ^a   Avantaggiato, Virginia ^a   Di Bonito, Maria ^a   Vaccarino, Flora M ^b   Michaud, Jacques ^c   Simeone, Antonio ^a  

^a INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Cell migration; Cell proliferation; Neuroendocrine hypothalamus; Orthopedia; Terminal differentiation

Indexed keywords

ARGIPRESSIN; CORTICOTROPIN RELEASING FACTOR; OXYTOCIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; CELL LINEAGE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HOMEOBOX; HYPOTHALAMUS; MOUSE; NEUROSECRETORY CELL; NONHUMAN; OXYTOCIN RELEASE; PRIORITY JOURNAL;

ANIMALIA;

EID: 0032702290     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.21.2787     Document Type: Article

References (39)

1. Acampora, D., S. Mazan, F. Tuorto, V. Avantaggiato, J.J. Tremblay, D. Lazzaro, A. di Carlo, A. Mariano, P.E. Macchia, G. Corte et al. 1998. Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH. Development 125: 1229-1239.
2. Alvarez-Bolado, G., M.G. Rosenfeld, and L.W Swanson. 1995. Model of forebrain regionalization based on spatiotemporal patterns of POU-III homeobox gene expression, birthdates, and morphological features. J. Comp. Neurol. 355: 237-295.
3. Avantaggiato, V., P.P. Pandolfi, M. Ruthardt, N. Hawe, D. Acampora, P.G. Pelicci, and A. Simeone. 1995. Developmental analysis of the murine Promyelocyte Leukaemia Zinc Finger (PLZF) gene expression: Implications for the neuromeric model of the forebrain organization. J. Neurosci. 15: 4927-4942.
4. Bach, I., S.J., Rhodes, R.V. Pearse II, T. Heinzel, B. Gloss, K.M. Scully, P.E. Sawchenko, and M.G. Rosenfeld. 1995. P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1. Proc. Natl. Acad. Sci. 92: 2720-2724.
5. Bach, I., C. Carrière, H.P. Ostendorff, B. Andersen, and M.G. Rosenfeld. 1997. A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. Genes & Dev. 11: 1370-1380.
6. Bodner, M., J.L. Castrillo, L.E. Theill, T. Deerinck, M. Ellisman, and M. Karin. 1988. The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. Cell 55: 505-518.
7. Bulfone, A., L. Puelles, M.H. Porteus, M.A. Frohman, G.R. Martin, and J.L.R. Rubenstein. 1993. Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries. J. Neurosci. 13: 3155-3172.
8. Cohen, S.M. 1990. Specification of limb development in the Drosophila embryo by positional cues from segmentation genes. Nature 343: 173-177.
9. Enderlin, S., A.W. Norman, and M.R. Celio. 1987. Ontogeny of the calcium binding protein calbindin D-28K in the rat nervous system. Anat. Embryol. 177: 15-28.
10. Felig, P., J.D. Baxter, A.E. Brodaus, and L.A. Frohman. 1987. In Endocrinology and metabolism McGraw-Hill, New York, NY.
11. Figdor, M.C. and C.D. Stern. 1993. Segmental organization of embryonic diencephalon. Nature 363: 630-634.
12. Gass, G.H. and H.M. Kaplan. 1996. In Handbook of endocrinology. 2nd ed. CRC Press, Inc, Boca Raton, FL.
13. Gavrieli, Y., Y. Sherman, and S.A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119: 493-501.
14. He, X., A. Treacy, M.N. Simmons, D.M. Ingraham, H.A. Swanson, and M.G. Rosenfeld. 1989. Expression of a large family of POU-domain regulatory genes in mammalian brain development. Nature 340: 35-41.
15. Ingraham, H.A., R.P. Chen, H.J. Mangalam, H.P. Elsholtz, S.E. Flynn, Lin, C.R., D.M. Simmons, L. Swanson, and M.G. Rosenfeld. 1988. A tissue-specific transcription factor containing a homeobox specifies a pituitary phenotype. Cell 55: 519-529.
16. Karim, M.A. and J.C. Sloper. 1980. Histogenesis of the supraoptic and paraventricular neurosecretory cells of the mouse hypothalamus. J. Anat. 130: 341-347.
17. Lamoniere, T., J.J. Tremblay, C. Lanctôt, M. Therrien, Y. Gauthier, and J. Drouin. 1996. Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the proopiomelanocortin gene. Genes & Dev. 10: 1284-1294.
18. Le Mouellic, H., Y. Lallemand, and P. Brûlet. 1990. Targeted replacement of the homeobox gene Hox-3.1 by the Escherichia coli lacZ in mouse chimeric embryos. Proc. Natl. Acad. Sci. 87: 4712-4716.
19. Li, H., P.S. Zeitler, M.T. Valerius, K. Small, and S.S. Potter. 1996. Gsh-1, an orphan Hox gene, is required for normal pituitary development. EMBO J. 15: 714-724.
20. Li, S., E.B. Crenshaw, E.J. Rawson, D.M. Simmons, L.W. Swanson, and M.G. Rosenfeld. 1990. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature 347: 528-533.
21. Lin, X., M.W. State, F.M. Vaccarino, J. Greally, M. Hass, and J.F. Leckman. 1999. Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP). Genomics 60: 96-104.
22. Michaud, J.L., T. Rosenquist, N.R. May, and C.-M. Fan. 1998. Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1. Genes & Dev. 12: 3264-3275.
23. Nakai, S., H. Kawano, T. Yudate, M. Nishi, J. Kuno, A. Nagata, K. Jishage, H. Hamada, H. Fujii, K. Kawamura, K. Shiba, and T. Noda. 1995. The POU domain transcription factor Brn-2 is required for the determination of specific neuronal lineages in the hypothalamus of the mouse. Genes & Dev. 9: 3109-3121.
24. Price, M., M. Lemaistre, M. Pischetola, R. Di Lauro, and D. Duboule. 1991. A mouse gene related to distal-less shows a restricted expression in the developing forebrain. Nature 351: 748-751.
25. Puelles, L. and J.L.R. Rubenstein. 1993. Expression patterns of homeobox and other putative regulatory genes in the embryonic mouse forebrain suggest a neuromeric organization. Trends Neurosci. 16: 472-479.
26. Rubenstein, J.L.R., S. Martinez, K. Shimamura, and L. Puelles. 1994. The embryonic vertebrate forebrain: The prosomeric model. Science 266: 578-580.
27. Schonemann, M.D., A.K. Ryan, R.J. McEvilly, S.M. O'Connell, C.A. Arias, K.A. Kalla, P. Li, P.E. Sawchenko, and M.G. Rosenfeld. 1995. Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2. Genes & Dev. 9: 3122-3135.
28. Sharp, D.Z. and W.W. Morgan. 1996. Brain POU-er. BioEssays 18: 347-350.
29. Sheng, H.Z., A.B. Zhadanov, B. Mosinger, Jr., T. Fujii, S. Bertuzzi, A. Grinberg, E.J. Lee, S.-P. Huang, K.A. Mahon, and H. Westphal. 1996. Specification of pituitary cell lineages by the LIM homeobox gene Lhx3. Science 272: 1004-1007.
30. Simeone, A. 1998. Detection of mRNA in tissue sections with radiolabelled riboprobes. In In situ hybridization. A practical approach (ed. D.G. Wilkinson), 2nd ed., pp 69-86. Oxford University Press, Oxford UK.
31. Simeone, A., M.R. D'Apice, V. Nigro, J. Casanova, F. Graziani, D. Acampora, and V. Avantaggiato. 1994. Orthopedia, a novel homeobox-containing gene expressed in the developing central nervous system of both mouse and Drosophila. Neuron 13: 83-101.
32. Simmons, D.M., J.W. Voss, H.A. Ingraham, J.M. Halloway, R.S. Broide, M.G. Rosenfeld, and L.W. Swanson. 1990. Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors. Genes & Dev. 4: 695-711.
33. Sornson, M.W., W. Wu, J.S. Dasen, S.E. Flynn, D.J. Norman, S.M. O'Connell, I. Gukovsky, C. Carrière, A.K. Ryan, A.P. Miller et al. 1996. Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature 384: 327-333.
34. Swanson, L.W. 1986. Organization of mammalian neuroendocrine system. In Handbook of physiology. Sec. 1, The nervous system, Vol. IV, Intrinsic regulatory systems of the brain (ed. V.B. Mountcastle, Floyd E. Bloom, and S.R. Geinger), pp. 317-363. American Physiological Society, Bethesda, MD.
35. _. 1987. The hypothalamus. In Handbook of chemical neuroanatomy, Part I (ed. A. Bjorklun, T. Hokfelt, and L.W. Swanson), pp. 1-124. Elsevier Publishing Company, Amsterdam, The Netherlands.
36. Szeto, D.P., A.K. Ryan, S.M. O'Connell, and M.G. Rosenfeld. 1996. P-OTX: A Pit-1 interacting homeodomain factor expressed during anterior pituitary gland development. Proc. Natl. Acad. Sci. 93: 7706-7710.
37. Treier, M. and M.G. Rosenfeld. 1996. The hypothalamic-pituitary axis: Co-development of two organs. Curr. Opin. Cell Biol. 8: 833-843.
38. Wilson, J.D. and D.W. Foster. 1992. In Williams textbook of endocrinology. 8th ed., W.B. Saunders Company, Philadelphia, PA.
39. Xuan, S., C.A. Baptista, G. Balas, W. Tao, V.C. Scares, and E. Lai. 1995. Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres. Neuron 14: 1141-1152.