A residue in the intracellular vestibule of the pore is critical for gating and permeation in Ca2+-activated K+(BK(Ca)) channels

Journal of Physiology

Volumn 529, Issue 1, 2000, Pages 131-138

  Lippiat, J D ^a   Standen, N B ^a   Davies, N W ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; IBERIOTOXIN; ISOLEUCINE; POTASSIUM CHANNEL; POTASSIUM ION; TYROSINE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

AMINO ACID SUBSTITUTION; ARTICLE; CELL MEMBRANE POTENTIAL; CELL MUTANT; CELL STRAIN; CHANNEL GATING; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; ION PERMEABILITY; KIDNEY CELL CULTURE; NUCLEOTIDE SEQUENCE; PATCH CLAMP; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; CALCIUM CELL LEVEL; CALCIUM CONDUCTANCE; CALCIUM CURRENT; CALCIUM TRANSPORT; EMBRYO; MEMBRANE POTENTIAL; PATCH CLAMP TECHNIQUE; PROTEIN DOMAIN; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS;

EID: 0034668792     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2000.00131.x     Document Type: Article

References (24)

1. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons
2. Ion conductance and selectivity of single calcium-activated potassium channels in cultured rat muscle
3. Intracorporal injection of hSlo cDNA in rats produces physiologically relevant alterations in penile function
4. Role of the S6 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
5. 2+ -activated K+ channels
6. + conduction and selectivity
7. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
8. 2+
9. 2+
10. Aromatic residues affecting permeation and gating in dSlo channels
11. Block of cloned BK(Ca) channels (rSlo) expressed in HEK 293 cells by N-methyl D-glucamine
12. + channel
13. + channels in rat skeletal muscle
14. + channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (SO-S6), an extracellular N terminus, and an terminus
15. + channel
16. Reconstitution of a voltage and calcium dependent potassium channel from rat cerebellum
17. A novel calcium-sensing domain in the BK channel
18. Transplantable sites confer calcium sensitivity to BK channels
19. Tetraethylammonium block of Slowpoke calcium-activated potassium channels expressed in Xenopus oocytes: Evidence for tetrameric channel formation
20. Characterization of gating and peptide block of mSlo, a cloned calcium-dependent potassium channel
21. Complex voltage-dependent behaviour of single unliganded calcium-sensitive potassium channels
22. Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium
23. Calcium sensitivity of BK-type K(Ca) channels determined by a separable domain