Aromatic residues affecting permeation and gating in dSlo BK channels

Pflugers Archiv European Journal of Physiology

Volumn 435, Issue 5, 1998, Pages 731-739

  Lagrutta, Armando A ^a,b   Shen, Ke Zhong ^a   Rivard, André ^a   North, R Alan ^a,c   Adelman, John P ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c GLAXO INST FOR MOLECULAR BIOLOGY   (Switzerland)

Author keywords

Ca2+ activated K+ channels; K+ channel; P loop; Pore region; Site directed mutagenesis

Indexed keywords

POTASSIUM CHANNEL; TETRYLAMMONIUM;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CHEMICAL MODIFICATION; ION CONDUCTANCE; ION CURRENT; MUTANT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; XENOPUS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ELECTRIC CONDUCTIVITY; EVOKED POTENTIALS; ION CHANNEL GATING; KINETICS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PERMEABILITY; PHENYLALANINE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; TETRAETHYLAMMONIUM; TYROSINE; XENOPUS;

EID: 0031908179     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240050575     Document Type: Article

References (32)

1. Adelman JP, Shen K-Z, Kavanaugh MP, Warren RA, Wu Y-N, Lagrutta A, Bond CT, North RA (1992) Calcium-activated potassium channels expressed from complementary DNAs. Neuron 9:209-216
2. + channels from skeletal and smooth muscle. Coupling of ion and water fluxes. Biophys J 55:367-371
3. Atkinson NS, Rohertson GA, Ganetzky B (1991) A component of calcium-activated potassium channels encoded by the Drosophila slo locus. Science 253:551-553
4. Butler A, Tsunoda S, McCobb D, Wei A, Salkoff L (1993) mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels. Science 261:221-224
5. Cecchi X, Alvárez, O. Wolff D (1986) Characterization of a calcium-activated potassium channel from rabbit intestinal smooth muscle incorporated into planar bilayers. J Membr Biol 91:11-18
6. Colquhoun D, Sigworth FJ (1995) Hitting and statistical analysis of single-channel records. In: Sakmann B, Neher E (eds) Single-channel recording. Plenum, New York, pp 483-587
7. 2+ channel model without ionic interaction. Biophys J 70:A184
8. Dawson RMC, Elliot DC, Elliot WH, Jones KM (1969) Data for biochemical research. Oxford University Press, New York
9. + pore. Biophys J 65:1235-1242
10. + channels. J Physiol (Lond) 489:403-418
11. + channel. Neuropharmacology 35:761-773
12. Dworetzky SI, Tojnacki JT, Gribkoff VK (1994) Cloning and expression of a human large-conductance calcium-activated potassium channel. Brain Res Mol Brain Res 27:189-193
13. Eisenman G (1962) Cation selective glass electrodes and their mode of operation. Biophys J 2 [Suppl 2]:259-323
14. Hille B (1992) Ionic channels of excitable membranes, 2nd edn. Sinauer Associates, Sunderland, Mass.
15. Kavanaugh MP, Hurst RS, Yakel J, Varnum MD, Adelman JP, North RA (1992) Multiple subunits of a voltage-dependent potassium channel contribute to the binding site for tetraethylammonium. Neuron 8:493-497
16. + channels determined by an interacting pair of nonpolar amino acids. Neuron 8:499-505
17. Latorre R, Miller C (1983) Conduction and selectivity in potassium channels. J Membr Biol 71:11-30
18. Latorre R, Oberhauser A, Labarca P, Alvarez O (1989) Varieties of calcium-activated potassium channels. Annu Rev Physiol 51:385-399
19. Lipkind GM, Hanck DA, Fozzard HA (1995) A structural motif for the voltage-gated potassium channel pore. Proc Natl Acad Sci USA 92:9215-9219
20. + channels. Science 250:276-279
21. McCobb DP, Fowler NL, Featherstone T, Lingle CJ, Saito M, Krause JE, Salkoff L (1995) A human calcium-activated potassium channel gene expressed in vascular smooth muscle. Am J Physiol 269:H767-H777
22. + channel. J Gen Physiol 92:569-586
23. + channels. J Gen Physiol 97:641-665
24. Pascual JM, Shieh C-C, Kirsch GE, Brown AM (1995) Multiple residues specify external tetraethylamnionium blockade in voltage-gated potassium channels. Biophys J 69:428-434
25. + channels. Biophys J 66:1929-1938
26. + channel, expressed in oocytes. Biophys J 70:2640-2651 (editorial correction Biophys J 71:517)
27. Shen K-Z, Lagrutta A, Davies NW, Standen NB, Adelman JP, North RA (1994) Tetraethylammonium block of Slowpoke calcium-activated potassium channels expressed in Xenopus oocytes: evidence for tetrameric channel formation. Pflügers Arch 426:440-445
28. 2+-dependent activation of mSlo by binding to a low affinity site on the channel core. Biophys J 68:A30
29. + channel isoforms from human brain. Neuron 13:1315-1330
30. Ca channels determined by a separable domain. Neuron 13:671-681
31. Woodhull AM (1973) Ionic blockage of sodium channels in nerve. J Gen Physiol 61:687-708
32. + channels of bovine chromaffin cells. J Gen Physiol 84:157-186