Species-dependent and site-specific intestinal metabolism of ester prodrugs

International Journal of Pharmaceutics

Volumn 205, Issue 1-2, 2000, Pages 93-100

  Van Gelder, J ^a   Shafiee, M ^a   De Clercq, E ^b   Penninckx, F ^c   Van Den Mooter, G ^a   Kinget, R ^a   Augustijns, P ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Antiviral; Esterase; Intestinal metabolism; Oral absorption; p Nitrophenyl acetate; Tenofovir disoproxil

Indexed keywords

4 NITROPHENYL ACETATE; ANTIVIRUS AGENT; BIS(ISOPROPYLOXYCARBONYLOXYMETHYL) 9 [2 (PHOSPHONOMETHOXY)PROPYL]ADENINE; CARBOXYLESTERASE; ESTER DERIVATIVE; ESTERASE; NUCLEOSIDE DERIVATIVE; PRODRUG; TENOFOVIR DISOPROXIL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; COLON ABSORPTION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DEGRADATION; DRUG METABOLISM; DUODENUM; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; ILEUM; JEJUNUM; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL INTESTINE ABSORPTION; SPECIES DIFFERENCE; SWINE; TISSUE HOMOGENATE;

ANIMAL; CACO-2 CELLS; ESTERS; HUMAN; INTESTINES; MALE; NITROPHENOLS; PRODRUGS; RATS; SPECIES SPECIFICITY; SUPPORT, NON-U.S. GOV'T; SWINE;

EID: 0034665485     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00507-X     Document Type: Article

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