Contribution of steroidogenic factor 1 to the regulation of cholesterol synthesis

Biochemical Journal

Volumn 350, Issue 3, 2000, Pages 785-790

  Mascaro, C ^a   Nadal, A ^a   Hegardt, F G ^a   Marrero, P F ^a   Haro, D ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Nuclear receptors; Steroidogenesis; Transcription

Indexed keywords

25 HYDROXYCHOLESTEROL; ACETIC ACID; BETA GALACTOSIDASE; CARBON 14; CELL NUCLEUS RECEPTOR; CHLORAMPHENICOL ACETYLTRANSFERASE; CHOLESTEROL; COMPLEMENTARY DNA; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; MESSENGER RNA; MEVALONIC ACID; STEROID HORMONE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; STEROIDOGENIC FACTOR 1; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DNA SEQUENCE; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; LEYDIG CELL TUMOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; STEROIDOGENESIS; TRANSCRIPTION REGULATION;

ANIMAL; BASE SEQUENCE; BINDING SITES; CELL LINE; CHOLESTEROL; CYTOSOL; DNA PRIMERS; DNA-BINDING PROTEINS; HAMSTERS; HYDROXYCHOLESTEROLS; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0034664937     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3500785     Document Type: Article

References (33)

1. Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. Isolation and sequencing of a full-length cDNA
2. Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. Isolation of the gene and characterization of the 5'-flanking region
3. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
4. Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I
5. Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression
6. Nuclear receptor steroidogenic factor 1 regulates the mullerian inhibiting substance gene: A link to the sex determination cascade
7. Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases
8. The orphan receptor NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction
9. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation
10. Mice deficient in the orphan steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids
11. Activation of the orphan nuclear receptor steroidogenic factor 1 by steroids
12. 25-Hydroxycholesterol is not a ligand for the orphan nuclear receptor steroidogenic factor 1 (SF-1)
13. Oxysterol regulation of steroidogenic acute regulatory protein gene expression
14. High levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in the ovary of the pregnant rabbit
15. Hormonal modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in gonadotropin-stimulated and desensitized testicular Leydig cells
16. Structure and localization of the human gene encoding SR-BI/CLA-1. Evidence for transcriptional control by Steroidogenic Factor-1
17. Site-directed mutagenesis by overlap extension using the polymerase chain reaction
18. Steroidogenic Factor-1 mediates cyclic 3',5'-adenosine monophosphate regulation of the High Density Lipoprotein Receptor
19. Developmental and hormonal regulation of murine scavenger receptor, class B, type 1
20. CAT constructions with multiple unique restrictions sites for the functional analysis of eucaryotic promoters and regulatory elements
21. The roles of steroidogenic factor-1 in reproductive function
22. Preparation of lipids extracts: Extraction with chloroform-methanol
23. Isolation and characterization of a mammalian cell mutant defective in 3-hydroxy-3-methylglutaryl coenzyme A synthase
24. Nuclear orphan receptors control cholesterol catabolism
25. An oxysterol signalling pathway mediated by the nuclear receptor LXRα
26. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
27. The orphan nuclear receptor LXRα is positively and negatively regulated by distinct products of mevalonate metabolism
28. Cholestserol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
29. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
30. Identification of a nuclear receptor for bile acids
31. Bile acids: Natural ligands for an orphan nuclear receptor