Very low density lipoprotein receptor in Alzheimer disease

Microscopy Research and Technique

Volumn 50, Issue 4, 2000, Pages 273-277

  Helbecque, Nicole ^a   Amouyel, Philippe ^a,b  

^a INSTITUT PASTEUR DE LILLE   (France)

^b UNIV LILLE   (France)

Author keywords

Dementia; Polymorphism; VLDL receptor

Indexed keywords

LIPOPROTEINS; NEURODEGENERATIVE DISEASES;

ALZHEIMERS DISEASE; APOLIPOPROTEINS; DEMENTIA; ISOFORMS; LIPOPROTEIN RECEPTOR-RELATED PROTEINS; LOW DENSITY LIPOPROTEIN RECEPTORS; POSSIBLE MECHANISMS; SPORADICS; STRUCTURAL MOTIFS; VERY LOW DENSITY LIPOPROTEIN RECEPTORS;

POLYMORPHISM;

APOLIPOPROTEIN E; APOLIPOPROTEIN E2; APOLIPOPROTEIN E4; LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN RECEPTOR;

ALLELE; ALZHEIMER DISEASE; DNA POLYMORPHISM; GENOTYPE; HEREDITY; HUMAN; NERVE DEGENERATION; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

EID: 0034663049     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0029(20000815)50:4<273::AID-JEMT4>3.0.CO;2-0     Document Type: Review

References (30)

1. Alcantara S, Ruiz M, D'Arcangelo G, Ezan F, de Lecea L, Curran T, Sotelo C, Soriano E. 1998. Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse. J Neurosci 18:7779-7799.
2. Arinami T, Takekoshi K, Yanagi H, Hamamoto M, Hamaguchi H. 1996. The 5-repeat allele in the very-low-density lipoprotein receptor gene polymorphism is not increased in sporadic Alzheimer's disease in Japanese. Neurology 47:1349-1350.
3. Brookes AJ, Howell WM, Woodburn K, Johnstone EC, Carothers A. 1997. Presenilin-I, presenilin-II, and VLDL-R associations in early onset Alzheimer's disease. Lancet 350:336-337.
4. Chen L, Baum L, Ng HK, Chan YS, Mak YT, Woo J, Chiu H, Pang CP. 1998. No association detected between very-low-density lipoprotein receptor (VLDL-R) and late-onset Alzheimer's disease in Hong Kong Chinese. Neurosci Lett 241:33-36.
5. Christie RH, Chung H, Rebeck GW, Strickland D, Hyman BT. 1996. Expression of the very low-density lipoprotein receptor (VLDL-r), an apolipoprotein-E receptor, in the central nervous system and in Alzheimer's disease. J Neuropathol Exp Neurol 55:491-498.
6. Chung H, Roberts CT, Greenberg S, Rebeck GW, Christie R, Wallace R, Jacob HJ, Hyman BT. 1996. Lack of association of trinucleotide repeat polymorphisms in very-low-density lipoprotein receptor gene with Alzheimer's disease. Ann Neurol 39:800-803.
7. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA. 1993. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261:921-923.
8. D'Arcangelo G, Homayouni R, Keshvara L, Rice DS, Sheldon M, Curran T. 1999. Reelin is a ligand for lipoprotein receptors. Neuron 24:471-479.
9. Fagan AM, Bu G, Sun Y, Daugherty A, Holtzman DM. 1996. Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein. J Biol Chem 271:30121-30125.
10. Fallin D, Gauntlett AC, Scibelli P, Cai X, Duara R, Gold M, Crawford F, Mullan M. 1997. No association between the very low density lipoprotein receptor gene and late-onset Alzheimer's disease nor interaction with the apolipoprotein E gene in population-based and clinic samples. Genet Epidemiol 14:299-305.
11. Frykman PK, Brown MS, Yamamoto T, Goldstein JL, Herz J. 1995. Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. Proc Natl Acad Sci U S A 92:8453-8457.
12. Gliemann J 1998. Receptors of the low density lipoprotein (LDL) receptor family in man. Multiple functions of the large family members via interaction with complex ligands. Biol Chem 379:951-964.
13. Helbecque N, Richard F, Cottel D, Neuman E, Guez D, Amouyel P. 1998. The very low density lipoprotein (VLDL) receptor is a genetic susceptibility factor for Alzheimer's disease in European Caucasian population. Alzheimer Dis Assoc Disord 12:368-371.
14. Hiesberger T, Trommsdorff M, Howell BW, Goffinet A, Mumby MC, Cooper JA, Herz J. 1999. Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron 24:481-9.
15. Iijima H, Miyazawa M, Sakai J, Magoori K, Ito MR, Suzuki H, Nose M, Kawarabayasi Y, Yamamoto TT. 1998. Expression and characterization of a very low density lipoprotein receptor variant lacking the O-linked sugar region generated by alternative splicing. J Biochem (Tokyo) 124:747-755.
16. Jokinen E, Sakai J, Yamamoto T, Hobbs HH. 1994. CGG triplet repeat polymorphism in VLDL receptor (VLDL-R) gene. Hum Mol Genet 3:521.
17. Lendon CL, Talbot CJ, Craddock NJ, Han SW, Wragg M, Morris JC, Goate AM. 1997. Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population. Neurosci Lett 222:187-190.
18. Mahley RW 1988. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240:622-630.
19. McIlroy SP, Vahidassr MD, Savage DA, Patterson CC, Lawson JT, Passmore AP. 1999. Risk of Alzheimer's disease is associated with a very low-density lipoprotein receptor genotype in Northern Ireland. Am J Med Genet 88:140-144.
20. Nakamura Y, Yamamoto M, Kumamaru E 1998. A variant very low density lipoprotein receptor lacking 84 base pairs of O-linked sugar domain in the human brain myelin. Brain Res 793:47-53.
21. Okuizumi K, Onodera O, Namba Y, Ikeda K, Yamamoto T, Seki K, Ueki A, Nanko S, Tanaka H, Takahashi H, et al. 1995. Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease. Nat Genet 11:207-209.
22. Okuizumi K, Onodera O, Seki K, Tanaka H, Namba Y, Ikeda K, Saunders AIM, Pericak-Vance MA, Roses AD, Tsuji S. 1996. Lack of association of very low density lipoprotein receptor gene polymorphism with Caucasian Alzheimer's disease. Ann Neurol 40:251-254.
23. Pritchard RIL, Saunders AM, Gaskell PC, Small GW, Conneally PM, Rosi B, Yamaoka LH, Roses AD, Haines JL, Pericak-Vance MA. 1996. No association between very low density lipoprotein receptor (VLDL-R) and Alzheimer disease in American Caucasians. Neurosci Lett 209:105-108.
24. Rubinsztein DC 1997. The genetics of Alzheimer's disease. Prog Neurobiol 52:447-454.
25. Sakai J, Hoshino A, Takahashi S, Miura Y, Ishii H, Suzuki H, Kawarabayasi Y, Yamamoto T. 1994. Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene. J Biol Chem 269:2173-2182.
26. Strittmatter WJ, Weisgraber KH, Goedert M, Saunders AM, Huang D, Corder EH, Dong LM, Jakes R, Alberts MJ, Gilbert JR, et al. 1994. Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Exp Neurol 125:163-171.
27. Trommsdorff M, Gotthardt M, Hiesberger T, Shelton, Stockinger W, Nimpf J, Hammer RE, Richardson JA, Herz J. 1999. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell 97:689-701.
28. Webb JC, Patel DD, Jones MD, Knight BL, Soutar AK. 1994. Characterization and tissue-specific expression of the human Very low density lipoprotein (VLDL) receptor' mRNA. Hum Mol Genet 3:531-537.
29. Yamamoto T, Bujo H 1996. Close encounters with apolipoprotein E receptors. Curr Opin Lipidol 7:298-302.
30. Yamanaka H, Kamimura K, Tanahashi H, Takahashi K, Asada T, Tabira T. 1998. Genetic risk factors in Japanese Alzheimer's disease patients: alpha1-ACT, VLDLR, and ApoE. Neurobiol Aging 19:S43-S46.