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Volumn 124, Issue 4, 1998, Pages 747-755

Expression and characterization of a very low density lipoprotein receptor variant lacking the O-linked sugar region generated by alternative splicing

Author keywords

Lipoprotein; O linked sugar; Splicing variant; VLDL receptor

Indexed keywords

CARBOHYDRATE; LOW DENSITY LIPOPROTEIN RECEPTOR; SERINE; THREONINE; VERY LOW DENSITY LIPOPROTEIN;

EID: 0031792704     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022175     Document Type: Article
Times cited : (46)

References (39)
  • 1
    • 0026778830 scopus 로고
    • Rabbit very low density lipoprotein receptor: A low density lipoprotein receptor-like protein with distinct ligand specificity
    • Takahashi, S., Kawarabayasi, Y., Nakai, T., Sakai, J., and Yamamoto, T. (1992) Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity. Proc. Natl. Acad. Sci. USA 89, 9252-9256
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9252-9256
    • Takahashi, S.1    Kawarabayasi, Y.2    Nakai, T.3    Sakai, J.4    Yamamoto, T.5
  • 3
    • 0029922119 scopus 로고    scopus 로고
    • Human apolipoprotein e receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain
    • Kim, D.H., Iijima, H., Goto, K., Sakai, J., Ishii, H., Kim, H.J., Suzuki, H., Kondo, H., Saeki, S., and Yamamoto, T. (1996) Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain. J. Biol. Chem. 271, 8373-8380
    • (1996) J. Biol. Chem. , vol.271 , pp. 8373-8380
    • Kim, D.H.1    Iijima, H.2    Goto, K.3    Sakai, J.4    Ishii, H.5    Kim, H.J.6    Suzuki, H.7    Kondo, H.8    Saeki, S.9    Yamamoto, T.10
  • 4
    • 0030968647 scopus 로고    scopus 로고
    • Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene
    • Kim, D.H., Magoori, K., Inoue, T.R., Mao, C.C., Kim, H.J., Suzuki, H., Fujita, T., Endo, Y., Saeki, S., and Yamamoto, T.T. (1997) Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene. J. Biol. Chem. 272, 8498-8504
    • (1997) J. Biol. Chem. , vol.272 , pp. 8498-8504
    • Kim, D.H.1    Magoori, K.2    Inoue, T.R.3    Mao, C.C.4    Kim, H.J.5    Suzuki, H.6    Fujita, T.7    Endo, Y.8    Saeki, S.9    Yamamoto, T.T.10
  • 6
    • 0023091262 scopus 로고
    • Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region
    • Davis, C.G., Goldstein, J.L., Südhof, T.C., Anderson, R.G., Russell, D.W., and Brown, M.S. (1987) Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region. Nature 326, 760-765
    • (1987) Nature , vol.326 , pp. 760-765
    • Davis, C.G.1    Goldstein, J.L.2    Südhof, T.C.3    Anderson, R.G.4    Russell, D.W.5    Brown, M.S.6
  • 7
    • 0025250145 scopus 로고
    • NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor
    • Chen, W.J., Goldstein, J.L., and Brown, M.S. (1990) NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. J. Biol. Chem. 265, 3116-3123
    • (1990) J. Biol. Chem. , vol.265 , pp. 3116-3123
    • Chen, W.J.1    Goldstein, J.L.2    Brown, M.S.3
  • 8
    • 0027812237 scopus 로고
    • Cloning of a cDNA encoding a putative human very low density lipoprotein/apolipoprotein E receptor and assignment of the gene to chromosome 9pter-p23
    • Gåfvels, M.E., Caird, M., Britt, D., Jackson, C.L., Patterson, D., and Strauss, J.F., III (1993) Cloning of a cDNA encoding a putative human very low density lipoprotein/apolipoprotein E receptor and assignment of the gene to chromosome 9pter-p23. Somat. Cell Mol. Genet. 19, 557-569
    • (1993) Somat. Cell Mol. Genet. , vol.19 , pp. 557-569
    • Gåfvels, M.E.1    Caird, M.2    Britt, D.3    Jackson, C.L.4    Patterson, D.5    Strauss III, J.F.6
  • 9
    • 0028324441 scopus 로고
    • Characterization and tissue-specific expression of the human 'very low density lipoprotein (VLDL) receptor' mRNA
    • Webb, J.C., Patel, D.D., Jones, M.D., Knight, B.L., and Soutar, A.K. (1994) Characterization and tissue-specific expression of the human 'very low density lipoprotein (VLDL) receptor' mRNA. Hum. Mol. Genet. 3, 531-537
    • (1994) Hum. Mol. Genet. , vol.3 , pp. 531-537
    • Webb, J.C.1    Patel, D.D.2    Jones, M.D.3    Knight, B.L.4    Soutar, A.K.5
  • 10
    • 0028037117 scopus 로고
    • Regulation of the very low density lipoprotein receptor by thyroid hormone in rat skeletal muscle
    • Jokinen, E.V., Landschulz, K.T., Wyne, K.L., Ho, Y.K., Frykman, P.K., and Hobbs, H.H. (1994) Regulation of the very low density lipoprotein receptor by thyroid hormone in rat skeletal muscle. J. Biol. Chem. 269, 26411-26418
    • (1994) J. Biol. Chem. , vol.269 , pp. 26411-26418
    • Jokinen, E.V.1    Landschulz, K.T.2    Wyne, K.L.3    Ho, Y.K.4    Frykman, P.K.5    Hobbs, H.H.6
  • 11
    • 0028232714 scopus 로고
    • Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: Expression pattern and assignment of the gene to mouse chromosome 19
    • Gåfvels, M.E., Paavola, L.G., Boyd, C.O., Nolan, P.M., Wittmaack, F., Chawla, A., Lazar, M.A., Bucan, M., Angelin, B.O., and Strauss, J.F., III (1994) Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19. Endocrinology 135, 387-394
    • (1994) Endocrinology , vol.135 , pp. 387-394
    • Gåfvels, M.E.1    Paavola, L.G.2    Boyd, C.O.3    Nolan, P.M.4    Wittmaack, F.5    Chawla, A.6    Lazar, M.A.7    Bucan, M.8    Angelin, B.O.9    Strauss III, J.F.10
  • 12
    • 0028136770 scopus 로고
    • Mouse very-low-density-lipoprotein receptor (VLDLR) cDNA cloning, tissue-specific expression and evolutionary relationship with the low-density-lipoprotein receptor
    • Oka, K., Ishimura-Oka, K., Chu, M.J., Sullivan, M., Krushkal, J., Li, W.H., and Chan, L. (1994) Mouse very-low-density-lipoprotein receptor (VLDLR) cDNA cloning, tissue-specific expression and evolutionary relationship with the low-density-lipoprotein receptor. Eur. J. Biochem. 224, 975-982
    • (1994) Eur. J. Biochem. , vol.224 , pp. 975-982
    • Oka, K.1    Ishimura-Oka, K.2    Chu, M.J.3    Sullivan, M.4    Krushkal, J.5    Li, W.H.6    Chan, L.7
  • 13
    • 0029807484 scopus 로고    scopus 로고
    • Close encounters with apolipoprotein e receptors
    • Yamamoto, T. and Bujo, H. (1996) Close encounters with apolipoprotein E receptors. Curr. Opin. Lipidol. 7, 298-302
    • (1996) Curr. Opin. Lipidol. , vol.7 , pp. 298-302
    • Yamamoto, T.1    Bujo, H.2
  • 14
    • 0029115499 scopus 로고
    • Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor
    • Frykman, P.K., Brown, M.S., Yamamoto, T., Goldstein, J.L., and Herz, J. (1995) Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. Proc. Natl. Acad. Sci. USA 92, 8453-8457
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 8453-8457
    • Frykman, P.K.1    Brown, M.S.2    Yamamoto, T.3    Goldstein, J.L.4    Herz, J.5
  • 15
    • 0029962807 scopus 로고    scopus 로고
    • Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor
    • Kobayashi, K., Oka, K., Forte, T., Ishida, B., Teng, B., Ishimura-Oka, K., Nakamuta, M., and Chan, L. (1996) Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor. J. Biol. Chem. 271, 6852-6860
    • (1996) J. Biol. Chem. , vol.271 , pp. 6852-6860
    • Kobayashi, K.1    Oka, K.2    Forte, T.3    Ishida, B.4    Teng, B.5    Ishimura-Oka, K.6    Nakamuta, M.7    Chan, L.8
  • 16
    • 0029988465 scopus 로고    scopus 로고
    • Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene
    • Kozarsky, K.F., Jooss, K., Donahee, M., Strauss, J.F., III, and Wilson, J.M. (1996) Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene. Nat. Genet. 13, 54-62
    • (1996) Nat. Genet. , vol.13 , pp. 54-62
    • Kozarsky, K.F.1    Jooss, K.2    Donahee, M.3    Strauss III, J.F.4    Wilson, J.M.5
  • 17
  • 18
    • 0028786941 scopus 로고
    • Mutant oocytic low density lipoprotein receptor gene family member causes atherosclerosis and female sterility
    • Bujo, H., Yamamoto, T., Hayashi, K., Hermann, M., Nimpf, J., and Schneider, W.J. (1995) Mutant oocytic low density lipoprotein receptor gene family member causes atherosclerosis and female sterility. Proc. Natl. Acad. Sci. USA 92, 9905-9909
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9905-9909
    • Bujo, H.1    Yamamoto, T.2    Hayashi, K.3    Hermann, M.4    Nimpf, J.5    Schneider, W.J.6
  • 20
    • 0028817837 scopus 로고
    • Chicken oocytes and somatic cells express different splice variants of a multifunctional receptor
    • Bujo, H., Lindstedt, K.A., Hermann, M., Dalmau, L.M., Nimpf, J., and Schneider, W.J. (1995) Chicken oocytes and somatic cells express different splice variants of a multifunctional receptor. J. Biol. Chem. 270, 23546-23551
    • (1995) J. Biol. Chem. , vol.270 , pp. 23546-23551
    • Bujo, H.1    Lindstedt, K.A.2    Hermann, M.3    Dalmau, L.M.4    Nimpf, J.5    Schneider, W.J.6
  • 21
    • 0023033288 scopus 로고
    • Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts
    • Davis, C.G., Elhammer, A., Russell, D.W., Schneider, W.J., Kornfeld, S., Brown, M.S., and Goldstein, J.L. (1986) Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts. J. Biol. Chem. 261, 2828-2838
    • (1986) J. Biol. Chem. , vol.261 , pp. 2828-2838
    • Davis, C.G.1    Elhammer, A.2    Russell, D.W.3    Schneider, W.J.4    Kornfeld, S.5    Brown, M.S.6    Goldstein, J.L.7
  • 24
    • 0021126647 scopus 로고
    • Receptor-mediated endocytosis of low density lipoprotein: Somatic cell mutants define multiple genes required for expression of surface-receptor activity
    • Kingsley, D.M. and Krieger, M. (1984) Receptor-mediated endocytosis of low density lipoprotein: somatic cell mutants define multiple genes required for expression of surface-receptor activity. Proc. Natl. Acad. Sci. USA 81, 5454-5458
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 5454-5458
    • Kingsley, D.M.1    Krieger, M.2
  • 25
    • 0023392945 scopus 로고
    • High-efficiency transformation of mammalian cells by plasmid DNA
    • Chen, C. and Okayama, H. (1987) High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7, 2745-2752
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 2745-2752
    • Chen, C.1    Okayama, H.2
  • 27
    • 0020973547 scopus 로고
    • Receptor-mediated endocytosis of low-density lipoprotein in cultured cells
    • Goldstein, J.L., Basu, S.K., and Brown, M.S. (1983) Receptor-mediated endocytosis of low-density lipoprotein in cultured cells. Methods Enzymol. 98, 241-260
    • (1983) Methods Enzymol. , vol.98 , pp. 241-260
    • Goldstein, J.L.1    Basu, S.K.2    Brown, M.S.3
  • 28
    • 0019546058 scopus 로고
    • Saturation and suppression of hepatic lipoprotein receptors: A mechanism for the hypercholesterolemia of cholesterol-fed rabbits
    • Kovanen, P.T., Brown, M.S., Basu, S.K., Bilheimer, D.W., and Goldstein, J.L. (1981) Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits. Proc. Natl. Acad. Sci. USA 78, 1396-1400
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 1396-1400
    • Kovanen, P.T.1    Brown, M.S.2    Basu, S.K.3    Bilheimer, D.W.4    Goldstein, J.L.5
  • 29
    • 0024806811 scopus 로고
    • Different combinations of cystein-rich repeats mediate binding of low density lipoprotein receptor to two different proteins
    • Russell, D.W., Brown, M.S., and Goldstein, J.L. (1989) Different combinations of cystein-rich repeats mediate binding of low density lipoprotein receptor to two different proteins. J. Biol. Chem. 264, 21682-21688
    • (1989) J. Biol. Chem. , vol.264 , pp. 21682-21688
    • Russell, D.W.1    Brown, M.S.2    Goldstein, J.L.3
  • 30
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 31
    • 0016703412 scopus 로고
    • Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339
    • Goldstein, J.L., Brunschede, G.Y., and Brown, M.S. (1975) Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339. J. Biol. Chem. 250, 7854-7862
    • (1975) J. Biol. Chem. , vol.250 , pp. 7854-7862
    • Goldstein, J.L.1    Brunschede, G.Y.2    Brown, M.S.3
  • 32
    • 0019427474 scopus 로고
    • Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts
    • Basu, S.K., Goldstein, J.L., Anderson, R.G., and Brown, M.S. (1981) Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts. Cell 24, 493-502
    • (1981) Cell , vol.24 , pp. 493-502
    • Basu, S.K.1    Goldstein, J.L.2    Anderson, R.G.3    Brown, M.S.4
  • 33
    • 0025297888 scopus 로고
    • Why are proteins O-glycosylated?
    • Jentoft, N. (1990) Why are proteins O-glycosylated? Trends Biochem. Sci. 15, 291-294
    • (1990) Trends Biochem. Sci. , vol.15 , pp. 291-294
    • Jentoft, N.1
  • 34
    • 0024509492 scopus 로고
    • Oocytes from the mutant restricted ovulator hen lack receptor for very low density lipoprotein
    • Nimpf, J., Radosavljevic, M.J., and Schneider, W.J. (1989) Oocytes from the mutant restricted ovulator hen lack receptor for very low density lipoprotein. J. Biol. Chem. 264, 1393-1398
    • (1989) J. Biol. Chem. , vol.264 , pp. 1393-1398
    • Nimpf, J.1    Radosavljevic, M.J.2    Schneider, W.J.3
  • 36
    • 0026652905 scopus 로고
    • Diagnosis of heterozygous familial hypercholesterolemia. DNA analysis complements clinical examination and analysis of serum lipid levels
    • Koivisto, P.V., Koivisto, U.M., Miettinen, T.A., and Kontula, K. (1992) Diagnosis of heterozygous familial hypercholesterolemia. DNA analysis complements clinical examination and analysis of serum lipid levels. Arterioscler. Thromb. 12, 584-592
    • (1992) Arterioscler. Thromb. , vol.12 , pp. 584-592
    • Koivisto, P.V.1    Koivisto, U.M.2    Miettinen, T.A.3    Kontula, K.4
  • 37
    • 0027331224 scopus 로고
    • Deletion of exon 15 of the LDL receptor gene is associated with a mild form of familial hypercholesterolemia. FH-Espoo
    • Koivisto, P.V., Koivisto, U.M., Kovanen, P.T., Gylling, H., Miettinen, T.A., and Kontula, K. (1993) Deletion of exon 15 of the LDL receptor gene is associated with a mild form of familial hypercholesterolemia. FH-Espoo. Arterioscler. Thromb. 13, 1680-1688
    • (1993) Arterioscler. Thromb. , vol.13 , pp. 1680-1688
    • Koivisto, P.V.1    Koivisto, U.M.2    Kovanen, P.T.3    Gylling, H.4    Miettinen, T.A.5    Kontula, K.6
  • 38
    • 0022527678 scopus 로고
    • Reversible defects in O-linked glycosylation and LDL receptor expression in a UDP-Gal/UDP-GalNAc 4-epimerase deficient mutant
    • Kingsley, D.M., Kozarsky, K.F., Hobbie, L., and Krieger, M. (1986) Reversible defects in O-linked glycosylation and LDL receptor expression in a UDP-Gal/UDP-GalNAc 4-epimerase deficient mutant. Cell 44, 749-759
    • (1986) Cell , vol.44 , pp. 749-759
    • Kingsley, D.M.1    Kozarsky, K.F.2    Hobbie, L.3    Krieger, M.4


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