Lack of association of trinucleotide repeat polymorphisms in the very-low-density lipoprotein receptor gene with Alzheimer's disease

Annals of Neurology

Volumn 39, Issue 6, 1996, Pages 800-803

  Chung, Haeyong ^a   Roberts, Carol T ^a   Greenberg, Steven ^a   Rebeck, G William ^a   Christie, Richard ^a   Wallace, Robert ^b   Jacob, Howard J ^a   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4; LIPOPROTEIN RECEPTOR; TRINUCLEOTIDE; VERY LOW DENSITY LIPOPROTEIN;

ALLELE; ALZHEIMER DISEASE; ARTICLE; CHROMOSOME POLYMORPHISM; CODON; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC RISK; HUMAN; HUMAN TISSUE; MOLECULAR CLONING; PRIORITY JOURNAL; RECEPTOR GENE; TANDEM REPEAT;

ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEINS E; COHORT STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENOTYPE; HUMANS; JAPAN; LIPOPROTEINS, VLDL; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; TRINUCLEOTIDE REPEATS; UNITED STATES;

EID: 0030009126     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410390617     Document Type: Article

References (15)

1. Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high-avidity binding to β-amyloid and increased frequence of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 1993;90:1977-1981
2. Rebeck GW, Reiter JS, Strickland DK, Hyman BT. Apolipoprotein E in sporadic Alzheirner's disease: allelic variation and receptor interactions. Neuron 1993;11:575-580
3. Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993;43:1467-1472
4. Poirier J, Davignon J, Bouthillier D, et al. Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 1993;342:697-699
5. Corder EH, Saunders AM, Risch NJ, et al. Apolipoprotein E type 2 allele decreases the risk of late onset Alzheimer disease. Nature Genet 1994;7:180-184
6. West HL, Rebeck GW, Hyman BT. Frequency of the apolipoprotein E ε2 allele is diminished in sporadic Alzheimer disease. Neurosci Lett 1994;175:46-48
7. Sakai J, Hoshino A, Takahashi S, et al. Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene. J Biol Chem 1994;269:2173-2182
8. Okuizumi K, Onodera O, Namba Y, et al. Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease. Nature Genet 1995;11:207-209
9. Kounnas MZ, Moir RD, Rebeck GW, et al. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation. Cell 1995;82:331-340
10. Hyman BT, Gomez-Isla T, Briggs M, et al. Influence of APOE genotype on developing cognitive impairment in the general population. Soc Neurosci Abstr 1995;21:1008
11. Gomez-Isla T, West HL, Rebeck GW, et al. Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease. Ann Neurol 1996;39:62-70
12. Greenberg SM, Rebeck GW, Vonsattel JPG, et al. Apolipoprotein E ε4 and cerebral hemorrhage associated with amyloid angiopathy. Ann Neurol 1995;38:254-259
13. Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hha I. J Lipid Res 1990;31:545-548
14. Jokinen E, Sakai, J., Yamamoto T, Hobbs HH. CGG triple repeat polymorphism in VLDL receptor (VLDL-R) gene. Hum Mol Genet 1994;3:521
15. Kamboh M, Sanghera DK, Ferrell RE et al. APOE*4-associated Alzheimer's disease risk is modified by α1-antichymotrypsin polymorphism. Nature Genet 1995;10:486-488