Firing rate of nucleus accumbens neurons is dopamine-dependent and reflects the timing of cocaine-seeking behavior in rats on a progressive ratio schedule of reinforcement

Journal of Neuroscience

Volumn 20, Issue 14, 2000, Pages 5526-5537

  Nicola, Saleem M ^a,b   Deadwyler, Sam A ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Addiction; Cocaine; D1 receptors; D2 receptors; Dopamine; Multiunit recording; Nucleus accumbens; Progressive ratio; Reward; Self administration

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; COCAINE; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; ETICLOPRIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; COCAINE DEPENDENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SELF ADMINISTRATION; MALE; MODEL; NERVE CELL; NONHUMAN; NUCLEUS ACCUMBENS; PATHOGENESIS; PRIORITY JOURNAL; RAT; REINFORCEMENT; REWARD; SPIKE WAVE;

EID: 0034661791     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-14-05526.2000     Document Type: Article

References (72)

1. Arnold JM, Roberts DCS (1997) A critique of fixed and progressive ratio schedules used to examine the neural substrates of drug reinforcement. Pharmacol Biochem Behav 57:441-447.
2. Bedford JA, Bailey LP, Wilson MC (1978) Cocaine reinforced progressive ratio performance in the rhesus monkey. Pharmacol Biochem Behav 9:631-638.
3. Berridge KC, Robinson TE (1998) What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Rev 28:309-369.
4. Bowman EM, Brown VJ (1998) Effects of excitotoxic lesions of the rat ventral striatum on the perception of reward cost. Exp Brain Res 123:439-448.
5. Britton DR, Curzon P, Mackenzie RG, Kebabian JW, Williams JEG, Kerkman D (1991) Evidence for involvement of both D1 and D2 receptors in maintaining cocaine self-administration. Pharmacol Biochem Behav 39:911-915.
6. Caine SB, Koob GF (1994a) Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat. J Pharmacol Exp Ther 270:209-218.
7. Caine SB, Koob GF (1994b) Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food. J Exp Anal Behav 61:213-221.
8. Caine SB, Heinrichs SC, Coffin VL, Koob GF (1995) Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat. Brain Res 692:47-56.
9. Carelli RM, Deadwyler SA (1994) A comparison of nucleus accumbens neuronal firing patterns during cocaine self-administration and water reinforcement in rats. J Neurosci 14:7735-7746.
10. Carelli RM, Deadwyler SA (1996a) Dose-dependent transitions in nucleus accumbens cell firing and behavioral responding during cocaine self-administration sessions in rats. J Pharmacol Exp Ther 277:385-393.
11. Carelli RM, Deadwyler SA (1996b) Dual factors controlling activity of nucleus accumbens cell-firing during cocaine self-administration. Synapse 24:308-311.
12. Carelli RM, Deadwyler SA (1997) Cellular mechanisms underlying reinforcement-related processing in the nucleus accumbens: electrophysiological studies in behaving animals. Pharmacol Biochem Behav 57:1-10.
13. Carelli RM, King VC, Hampson RE, Deadwyler SA (1993) Firing patterns of nucleus accumbens neurons during cocaine self-administration in rats. Brain Res 626:14-22.
14. Carelli RM, Ijames S, Konstantopoulos J, Deadwyler SA (1999) Examination of factors mediating the transition to behaviorally correlated nucleus accumbens cell firing during cocaine self-administration in rats. Behav Brain Res 104:127-139.
15. Carelli RM, Ijames SG, Crumling AJ (2000) Evidence that separate neural circuits in the nucleus accumbens encode cocaine versus "natural" (water and food) reward. J Neurosci 20:4255-4266.
16. Chang J-Y, Sawyer SF, Lee R-S, Woodward DJ (1994) Electrophysiological and pharmacological evidence for the role of the nucleus accumbens in cocaine self-administration in freely moving rats. J Neurosci 14:1224-1244.
17. Corrigall WE, Coen KM (1991) Cocaine self-administration is increased by both D1 and D2 dopamine antagonists. Pharmacol Biochem Behav 39:799-802.
18. Depoortere RY, Li DH, Lane JD, Emmett-Oglesby MW (1993) Parameters of self-administration of cocaine in rats under a progressive-ratio schedule. Pharmacol Biochem Behav 45:539-548.
19. Gratton A, Wise RA (1994) Drug- and behavior-associated changes in dopamine-related electrochemical signals during intravenous cocaine self-administration in rats. J Neurosci 14:4130-4146.
20. Green JD (1958) A simple microelectrode for recording from the central nervous system. Nature 182:962.
21. Griffiths RR, Brady JV, Snell JD (1978) Progressive-ratio performance maintained by drug infusions: comparison of cocaine, diethylpropion, chlorphentermine, and fenfluramine. Psychopharmacology 56:5-13.
22. 1 receptor activation. J Physiol (Lond) 492:143-154.
23. Heimer L, Alheid GF, de Olmos J, Groenewegen HJ, Haber SN, Harlan RE, Zahm DS (1997) The accumbens: beyond the core-shell dichotomy. J Neuropsychiatry Clin Neurosci 9:354-381.
24. Hemby SE, Co C, Koves TR, Smith JE, Dworkin SI (1997) Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat. Psychopharmacology 133:7-16.
25. Hodos W (1961) Progressive ratio as a measure of reward strength. Science 134:943-944.
26. Hodos W, Kalman G (1963) Effects of increment size and reinforcer volume on progressive ratio performance. J Exp Anal Behav 6:387-392.
27. Hu XT, White FJ (1994) Loss of D1/D2 dopamine receptor synergisms following repeated administration of D1 or D2 receptor selective antagonists: electrophysiological and behavioral studies. Synapse 17:43-61.
28. Hubner CB, Moreton JE (1991) Effects of selective D1 and D2 dopamine antagonists on cocaine self-administration in the rat. Psychopharmacology 105:151-156.
29. Kiyatkin EA, Rebec GV (1996) Dopaminergic modulation of glutamate-induced excitations of neurons in the neostriatum and nucleus accumbens of awake, unrestrained rats. J Neurophysiol 75:142-153.
30. Kiyatkin EA, Rebec GV (1997) Iontophoresis of amphetamine in the neostriatum and nucleus accumbens of awake, unrestrained rats. Brain Res 771:14-24.
31. Kiyatkin EA, Rebec GV (1999) Striatal neuronal activity and responsiveness to dopamine and glutamate after selective blockade of D1 and D2 dopamine receptors in freely moving rats. J Neurosci 19:3594-3609.
32. Kiyatkin EA, Stein EA (1995) Fluctuations in nucleus accumbens dopamine during cocaine self-administration behavior: an in vivo electrochemical study. Neuroscience 64:599-617.
33. 1 dopamine receptor antagonist SCH 23390 increases cocaine self-administration in the rat. Neurosci Lett 79:315-320.
34. Li D-H, Depoortere RY, Emmett-Oglesby MW (1994) Tolerance to the reinforcing effects of cocaine in a progressive ratio paradigm. Psychopharmacology 116:326-332.
35. 1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat. Pharmacol Biochem Behav 45:239-242.
36. McGregor A, Roberts DCS (1993) Dopaminergic antagonism within the nucleus accumbens or the amygdala produces differential effects on intravenous cocaine self-administration under fixed and progressive ratio schedules of reinforcement. Brain Res 624:245-252.
37. McGregor A, Roberts DCS (1995) Effect of medial prefrontal cortex injections of SCH 23390 on intravenous cocaine self-administration under both a fixed and progressive ratio schedule of reinforcement. Behav Brain Res 67:75-80.
38. McGregor A, Baker G, Roberts DCS (1996) Effect of 6-hydroxydopamine lesions of the medial prefrontal cortex on intravenous cocaine self-administration under a progressive ratio schedule of reinforcement. Pharmacol Biochem Behav 53:5-9.
39. Nicola SM, Malenka RC (1997) Dopamine depresses excitatory and inhibitory synaptic transmission by distinct mechanisms in the nucleus accumbens. J Neurosci 17:5697-5710.
40. Nicola SM, Malenka RC (1998) Modulation of synaptic transmission by dopamine and norepinephrine in ventral but not dorsal striatum. J Neurophysiol 79:1768-1776.
41. Nicola SM, Kombian SB, Malenka RC (1996) Psychostimulants depress excitatory synaptic transmission in the nucleus accumbens via presynaptic D1-like dopamine receptors. J Neurosci 16:1591-1604.
42. Nicola SM, Surmeier DJ, Malenka RC (2000) Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens. Annu Rev Neurosci 23:185-215.
43. O'Brien CP, Childress AR, McLellan AT, Ehrman R (1992) Classical conditioning in drug-dependent humans. Ann NY Acad Sci 654:400-415.
44. Pan H-T, Menacherry S, Justice Jr JB (1991) Differences in the pharmacokinetics of cocaine in naive and cocaine-experienced rats. J Neurochem 56:1299-1306.
45. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. New York: Academic.
46. Peoples LL, West MO (1996) Phasic firing of single neurons in the rat nucleus accumbens correlated with the timing of intravenous cocaine self-administration. J Neurosci 16:3459-3473.
47. Peoples LL, Uzwiak AJ, Gee F, West MO (1997) Operant behavior during sessions of intravenous cocaine infusion is necessary and sufficient for phasic firing of single nucleus accumbens neurons. Brain Res 757:280-284.
48. Peoples LL, Gee F, Bibi R, West MO (1998a) Phasic firing time locked to cocaine self-infusion and locomotion: dissociable firing patterns of single nucleus accumbens neurons in the rat. J Neurosci 18:7588-7598.
49. Peoples LL, Uzwiak AJ, Guyette FX, West MO (1998b) Tonic inhibition of single nucleus accumbens neurons in the rat: a predominant but not exclusive firing pattern induced by cocaine self-administration sessions. Neuroscience 86:13-22.
50. Pettit HO, Justice JB (1989) Dopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysis. Pharmacol Biochem Behav 34:899-904.
51. Pettit HO, Ettenberg A, Bloom FE, Koob GF (1984) Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats. Psychopharmacol 84:167-173.
52. Ranaldi R, Pocock D, Zereik R, Wise RA (1999) Dopamine fluctuations in the nucleus accumbens during maintenance, extinction and reinstatement of intravenous D-amphetamine self-administration. J Neurosci 19:4102-4109.
53. Richarson NR, Roberts DCS (1996) Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy. J Neurosci Methods 66:1-11.
54. Richardson NR, Smith AM, Roberts DCS (1994) A single injection of either flupenthixol decanoate or haloperidol decanoate produces longterm changes in cocaine self-administration in rats. Drug Alcohol Depend 36:23-25.
55. Risner ME, Cone EJ (1986) Intravenous self-administration of fencamfamine and cocaine by beagle dogs under fixed-ratio and progressive-ratio schedules of reinforcement. Drug Alcohol Depend 17:93-101.
56. Risner ME, Goldberg SR (1983) A comparison of nicotine and cocaine self-administration in one dog: fixed-ratio and progressive-ratio schedules of intravenous drug infusion. J Pharmacol Exp Ther 224:319-326.
57. Risner ME, Silcox DL (1981) Psychostimulant self-administration by beagle dogs in a progressive-ratio paradigm. Psychopharmacology 75:25-30.
58. Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ (1987) Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 237:1219-1223.
59. Roberts DCS, Corcoran ME, Fibiger HC (1977) On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine. Pharmacol Biochem Behav 6:615-620.
60. Roberts DCS, Loh EA, Vickers G (1989) Self-administration of cocaine on a progressive ratio schedule in rats: dose-response relationship and effect of haloperidol pretreatment. Psychopharmacology 97:535-538.
61. Smith A, Piercey M, Roberts DCS (1995) Effect of (-)-DS 121 and (+)-UH 232 on cocaine self-administration in rats. Psychopharmacology 120:93-98.
62. Tsibulsky VL, Norman AB (1999) Satiety threshold: a quantitative model of maintained cocaine self-administration. Brain Res 839:85-93.
63. Uzwiak AJ, Guyette FX, West MO, Peoples LL (1997) Neurons in accumbens subterritories of therat: phasic firing time-locked within seconds of intravenous self-infusion. Brain Res 767:363-369.
64. Wachtel SR, Hu X-T, Galloway MP, White FJ (1989) D1 dopamine receptor stimulation enables the postsynaptic, but not autoreceptor, effects of D2 dopamine agonists in nigrostriatal and mesoaccumbens dopamine systems. Synapse 4:327-346.
65. White FJ (1987) D-1 dopamine receptor stimulation enables the inhibition of nucleus accumbens neurons by a D-2 receptor agonist. Eur J Pharmacol 135:101-105.
66. Wilson CJ (1998) Basal ganglia. In: The synaptic organization of the brain (Shepherd GM, ed), pp 329-375. New York: Oxford UP.
67. Winger G, Woods JH (1985) Comparison of fixed-ratio and progressiveratio schedules of maintenance of stimulant drug-reinforced responding. Drug Alcohol Depend 15:123-130.
68. Wise RA (1999) Cognitive factors in addiction and nucleus accumbens function: some hints from rodent models. Psychobiology 27:300-310.
69. Wise RA, Newton P, Leeb K, Burnette B, Pocock D, Justice JB (1995) Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats. Psychopharmacology 120:10-20.
70. Zar JH (1974) Biostatistical analysis. Englewood Cliffs, NJ: Prentice Hall.
71. Zhang X-F, Hu X-T, White FJ (1998) Whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons. J Neurosci 18:488-498.
72. Zito KA, Vickers G, Roberts DCS (1985) Disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens. Pharmacol Biochem Behav 23:1029-1036.