Cardiac allograft vasculopathy is abrogated by anti-CD8 monoclonal antibody therapy

Annals of Thoracic Surgery

Volumn 64, Issue 4, 1997, Pages 1019-1025

  Allan, James S ^a   Choo, Joseph K ^a   Vesga, Liana ^a   Arn, J Scott ^a   Pins, Michael R ^a   Sachs, David H ^a   Madsen, Joren C ^a  

^a Dept Surg Massachusetts Gen H ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MONOCLONAL ANTIBODY; OKT 8;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; GRAFT REJECTION; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTHERAPY; INTRAVENOUS DRUG ADMINISTRATION; LYMPHOCYTE DEPLETION; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANIMALS; ANIMALS, INBRED STRAINS; ANTIBODIES, MONOCLONAL; CD8-POSITIVE T-LYMPHOCYTES; CORONARY DISEASE; CORONARY VESSELS; CYCLOSPORINE; HEART TRANSPLANTATION; LYMPHOCYTE COUNT; SWINE; SWINE, MINIATURE; TRANSPLANTATION, HOMOLOGOUS;

EID: 0030669858     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(97)00796-0     Document Type: Article

References (22)

1. Hosenpud JD, Novick RJ, Bennett LE, Keck BM, Fiol B, Daily OP. The registry of the International Society for Heart and Lung Transplantation thirteenth official report - 1996 . J Heart Lung Transplant. 15:1996;655-674.
2. Billingham ME. Cardiac transplantation arteriosclerosis. Transplant Proc. 19:1987;19-25.
3. Johnson DE, Gao S, Schroeder JS, DeCampli WM, Billingham ME. The spectrum of coronary artery pathologic findings in human cardiac allografts. J Heart Lung Transplant. 8:1989;349-359.
4. Gao SZ, Hunt SA, Schroeder JS, Alderman EL, Hill IR, Stinson EB. Early development of accelerated graft coronary artery disease risk factors and course . J Am Coll Cardiol. 28:1996;673-679.
5. Gao SZ, Schroeder JS, Alderman E, et al. Prevalence of accelerated coronary artery disease in heart transplant survivors comparison of cyclosporin and azathioprine regimens . Circulation. 80:(Suppl 3):1989;100-105.
6. Hosenpud JD. Immune mechanisms of cardiac allograft vasculopathy an update . Transplant Immunol. 1:1993;237-249.
7. Russell PS, Chase CM, Winn HJ, Colvin RB. Coronary atherosclerosis in transplanted mouse hearts. I. Time course and immunogenetic and immunopathological considerations. Am J Pathol. 144:1994;260-274.
8. Russell PS, Chase CM, Winn HJ, Colvin RB. Coronary atherosclerosis in transplanted mouse hearts. II. Importance of humoral immunity. J Immunol. 152:1994;5135-5141.
9. Sachs DH, Leight G, Cone J, Schwartz S, Stuart L, Rosenberg S. Transplantation in miniature swine. I. Fixation of the major histocompatibility complex. Transplantation. 22:1976;559-567.
10. Madsen JC, Sachs DH, Fallon JT, Weissman NJ. Cardiac allograft vasculopathy in partially inbred miniature swine. J Thorac Cardiovasc Surg. 111:1996;1230-1239.
11. Colvin RB, Chase CM, Winn HJ, Russell PS. Chronic allograft arteriopathy: insights from experimental models. Orosz CG, Sedmak DD, Ferguson RM. Transplant vascular sclerosis. 1995;7-33 R.G. Landes Co, Austin.
12. Pennington LR, Lunney JK, Sachs DH. Transplantation in miniature swine: VIII. Recombination within the major histocompatibility complex of miniature swine. Transplantation. 31:1981;66-75.
13. Suzuki T, Sundt TM III, Mixon A, Sachs DH. In vivo treatment with antiporcine T cell antibodies. Transplantation. 50:1990;76-81.
14. Pescovitz MD, Lunney JK, Sachs DH. Preparation and characterization of monoclonal antibodies reactive with porcine PBL. J Immunol. 133:1984;368-375.
15. Pescovitz MD, Lunney JK, Sachs DH. Murine anti-swine T4 and T8 monoclonal antibodies distribution and effects on proliferative and cytotoxic T cells . J Immunol. 134:1985;37-44.
16. Hammerberg C, Schurig GC. Characterization of monoclonal Ab directed against swine leukocytes. Vet Immunol Immunopathol. 11:1986;107-121.
17. Ozato K, Henkart P, Jensen C, Sachs DH. Spatially distinct allodeterminants of the H-2Kk molecule as detected by monoclonal anti-H-2 antibody. J Immunol. 126:1981;1780-1785.
18. Ivansoka D, Sun DC, Lunney JK. Production of monoclonal antibodies reactive with polymorphic and monomorphic determinants of SLA class I gene products. Immunogenetics. 33:1991;220-223.
19. Lurie KG, Billingham ME, Jamieson SW, Harrison DC, Reitz BA. Pathogenesis and prevention of graft arteriosclerosis in an experimental heart transplant model. Transplantation. 31:1981;41-47.
20. Madsen JC, Wood KJ, Morris PJ. Effects of anti-L3T4 and anti-Lyt 2 monoclonal antibodies on murine cardiac allograft rejection. Transplant Proc. 19:1987;3991-3992.
21. Clarke-Forbes RD, Zheng S, Gomersall M, Al-Saffar M, Guttmann RD. Evidence that recipient CD8+ T cell depletion does not alter development of chronic vascular rejection in a rat heart allograft model. Transplantation. 57:1994;1238-1246.
22. Pescovitz MD, Sachs DH, Lunney JK, Hsu SM. Localization of class II MHC antigen on porcine renal vascular endothelium. Transplantation. 37:1984;627-630.