Differential activation of focal adhesion kinase, Rho and Rac by the ninth and tenth FIII domains of fibronectin

Journal of Cell Science

Volumn 112, Issue 17, 1999, Pages 2937-2946

  Hotchin, Neil A ^a   Kidd, Alexander G ^a   Altroff, Harri ^b   Mardon, Helen J ^b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Fibronectin FIII domain; Focal adhesion kinase; Integrin; Rac; Rho

Indexed keywords

FIBRONECTIN; FOCAL ADHESION KINASE; GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INTEGRIN; INTEGRIN RECEPTOR; PROTEIN SUBUNIT; RHO FACTOR;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CELL STRAIN BHK; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; FIBROBLAST CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

3T3 CELLS; ACTINS; ANIMALS; CELL ADHESION; CELL ADHESION MOLECULES; CELL LINE; CRICETINAE; CULTURE MEDIA, SERUM-FREE; DRUG SYNERGISM; ENZYME ACTIVATION; FIBROBLASTS; FIBRONECTINS; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; KIDNEY; LYSOPHOSPHOLIPIDS; MESOCRICETUS; MICE; MICROFILAMENTS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; RAC GTP-BINDING PROTEINS; RECOMBINANT PROTEINS; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; SPHINGOSINE;

ANIMALIA;

EID: 0032872155     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Akiyama S. K., Aota, S. and Yamada, K. M. (1995). Function and receptor specificity of a minimal 20 kilodalton cell adhesive fragment of libronectin. Cell Adhesion Comm. 3, 13-25.
2. Aota, S., Nomizu, M. and Yamada, K. M. (1994). The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function. J. Biol. Chem. 269, 24756-24761.
3. Bourdoulous, S., Orend, G., MacKenna, D. A., Pasqualini, R. and Ruoslahti, E. (1998). Fibronectin matrix regulates activation of RHO and CDC42 GTPases and cell cycle progression. J. Cell Biol. 143, 267-276.
4. Bowditch, R. D., Hariharan, M., Tominna, E. F., Smith, J. W., Yamada, K. M., Getzoff, E. D. and Ginsberg, M. H. (1994). Identification of a novel integrin binding site in fibronectin. Differential utilization by beta 3 integrins. J. Biol. Chem. 269, 10856-10863.
5. FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly. J. Cell Biol. 119, 893-903.
6. Chen, H. C., and Guan, J. L. (1994). Stimulation of phosphatidylinositol 3′-kinase association with focal adhesion kinase by platelet-derived growth factor. J. Biol. Chem. 269, 31229-31233.
7. Clark, E.A., King, W. G., Brugge, J. S., Symons, M. and Hynes, R. O. (1998). Integrin-mediated signals regulated by members of the Rho family of GTPases. J. Cell Biol. 142, 573-586.
8. FAK tyrosine phosphorylation and focal adhesion assembly: studies with phosphotyrosine phosphatase inhibitors. Exp. Cell Res. 221, 141-152.
9. Fincham, V. J. and Frame, M. C. (1998). The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J. 17, 81-92.
10. Grant, R. P., Spitzfaden, C., Altroff, H., Campbell, I. D. and Mardon, H. J. (1997). Structural requirements for biological activity of the ninth and tenth FIII domains of human tibronectin. J. Biol. Chem. 272, 6159-6166.
11. Guan, J. L., Trevithick, J. E. and Hynes, R. O. (1991). Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regulation 2, 951-964.
12. Guan, J. L. and Shalloway, D. (1992). Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature 358, 690-692.
13. Hanks, S. K., Calalb, M. B., Harper, M. C. and Patel, S. K. (1992) Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc. Natl. Acad. Sci. USA 89, 8487-8491.
14. Hotchin, N. A. and Hall, A. (1995). The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J. Cell Biol. 131, 1857-1865.
15. Humphries, M. J., Komoriya, A., Akiyama, S. K., Olden, K. and Yamada, K. M. (1987). Identification of two distinct regions of the type III connecting segment of human plasma fibronectin that promote cell type-specific adhesion. J. Biol. Chem. 262, 6886-6892.
16. Hynes, R. (1992). Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25.
17. Ilic, D., Furuta, Y., Kanazawa, S., Takeda, N., Sobue, K., Nakatsuji, N., Nomura, S., Fujimoto, J., Okada, M., Yamamoto, T. and Aizawa, S. (1995). Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377, 539-543.
18. Kumagai, N., Morii, N., Fujisawa, K., Voshimasa, T., Nakao, K. and Narumiya, S. (1993). Lysophosphatidic acid induces tyrosine phosphorylation and activation of MAP-kinase and focal adhesion kinase in cultured Swiss 3T3 cells. FEBS Lett. 329, 273-276.
19. Leahy, D. J., Aukhil, I. and Erickson, H. P. (1996). 2.0 Å crystal structure of a four-domain segment of human fibronectin encompassing the ROD loop and synergy region. Cell 84, 155-164
20. Machesky, L.M. and Hall, A. (1997). Role of actin polymerization and adhesion to extracellular matrix in Rac-and Rho-induced cytoskeletal reoganization. J. Cell Biol. 138, 913-926.
21. Main, A. L., Harvey, T. S., Baron, M., Boyd, J. and Campbell, I. D. (1992). The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions. Cell 71, 671-678.
22. Mardon, H. J. and Grant, K. E. (1994). The role of the ninth and tenth type III domains of human fibronectin in cell adhesion. FEBS Lett. 340, 197-201.
23. Mould, A. P., Askari, J. A., Aota, S., Yamada, K. M., Irie, A., Takada, Y., Mardon, H. J. and Humphries, M. J. (1997). Defining the topology of integrin a5b1-fibronectin interactions using inhibitory anti-a5 and anti-b1 antibodies. J. Biol. Chem. 272, 17283-17292.
24. Nobes, C. D. and Hall, A. (1995). Rho, rac and cdc42 regulate the assembly of multi-molecular focal complexes associated with actin stress fibres. Iamellipodia and filopodia. Cell 81, 53-62.
25. Obara, M., Kang, M. S. and Yamada, K. M. (1988). Site-directed mutagenesis of the cell-binding domain of human fibronectin: separable, synergistic sites mediate adhesive function. Cell 53, 649-657.
26. Obara, M. and Yoshizato, K. (1995). Possible involvement of the interaction of the alpha 5 subunit of alpha 5 beta 1 integrin with the synergistic region of the central cell-binding domain of fibronectin in cells to fibronectin binding. Exp. Cell Res. 216, 273-276.
27. Pasqualini, R., Koivunen, E. and Ruoslahti, E. (1995). A peptide isolated from phage display libraries is a structural and functional mimic of an RGD-binding site on integrins. J. Cell Biol. 130, 1189-1196.
28. Pierschbacher, M. D. and Ruoslahti, E. (1984). Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309, 30-33.
29. Potts, J. R. and Campbell, I. D. (1994). Fibronectin structure and assembly. Curr. Opin. Cell Biol. 6, 648-655.
30. FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. Bell-shaped dose-response and cross-talk with bombesin. J. Cell Biol. 269, 704-710.
31. Renshaw, M. W., Ren, X-D. and Schwartz, M. A. (1997). Growth factor activation of MAP kinase requires cell adhesion. EMBO J. 16, 5592-5599.
32. Ridley, A. J. and Hall, A. (1992). The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.
33. Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. and Hall, A. (1992). The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410.
34. FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc. Natl Acad. Sci. USA 89, 5192-5196.
35. FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells. J. Biol. Chem. 269, 27610-27617.
36. Wang, F., Nobes, C. D., Hall, A. and Spiegel, S. (1997). Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts. Biochem. J. 324, 481-488.
37. Werb, Z., Tremble, P. M., Behrendtsen, O., Crowley, E. and Damsky, C. H. (1989). Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J. Cell Biol. 109, 877-889.
38. FAK): a point of convergence in the action of neuropeptides, integrins, and oncogenes. Cell 71, 891-894.