Effect of cyclooxygenase and nitric oxide synthase inhibitors on tumor growth in mouse tumor models with and without cancer cachexia related to prostanoids

Cancer Research

Volumn 60, Issue 6, 2000, Pages 1742-1749

  Cahlin, Christian ^a   Gelin, Johan ^a   Delbro, Dick ^a   Lönnroth, Christina ^a   Doi, Chiharu ^a   Lundholm, Kent ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

6 (2,4 DIFLUOROPHENYLTHIO) 5 METHANESULFONAMIDO 1 INDANONE; BASIC FIBROBLAST GROWTH FACTOR; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; MESSENGER RNA; N(G) NITROARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PROSTANOID; TRANSFERRIN RECEPTOR; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CACHEXIA; CANCER INHIBITION; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; ICOSANOID METABOLISM; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARCOMA;

ANIMALS; CACHEXIA; DINOPROSTONE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION; GROWTH SUBSTANCES; IMMUNOHISTOCHEMISTRY; INDANS; INDOMETHACIN; IODINE RADIOISOTOPES; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITROARGININE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0034654126     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Lönnroth, C. S., Gelin, G., Cahlin, C., Iresjö. B-M., Cvetkovska, E., Edström, S., Svanberg, E., and Lundholm, K. Effects related to indomethacin prolonged survival and decreased tumor growth in a mouse tumor model with cytokine dependent cancer cachexia. Int. J. Oncol., 7: 1404-1413, 1995.
2. Sawaoka, H., Kawano, S., Tsuji, S., Tsujii, M., Murata, H., and Hori, M. Effects of NSAIDs on proliferation of gastric cancer cells in vitro: possible implication of cyclooxygenase-2 in cancer development. J. Clin. Gastroenterol., 27: S47-S52, 1998.
3. Murata, H., Kawano, S., Tsuji, S., Tsuji, M., Sawaoka, H., Kimura, Y., Shiozaki, H., and Hori, M. Cyclooxygenase-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma. Am. J. Gastroenterol., 94: 451-455, 1999.
4. DuBois, R. N., Giardiello, F. M., and Smalley, W. E. Nonsteroidal anti-inflammatory drugs, eicosanoids, and colorectal cancer prevention. Gastroenterol. Clin. North Am., 25: 773-791, 1996.
5. Sandstrom, R., Gelin, J., and Lundholm, K. The effect of indomethacin on food and water intake, motor activity, and survival in tumour-bearing rats. Eur. J. Cancer, 26: 811-814, 1990.
6. Lundholm, K., Gelin, S., Hyltander, A., Lonnroth, C., Sandstrom, R., Svaninger, G., Korner, U., Gulich, M., Karrefors, I., Norli, B., et al. Anti-inflammatory treatment may prolong survival in undernourished patients with metastatic solid tumors. Cancer Res., 54: 5602-5606, 1994.
7. Gelin, J., Moldawer, L. L., Lonnroth, C., Sherry, B., Chizzonite, R., and Lundholm, K. Role of endogenous tumor necrosis factor a and interleukin 1 for experimental tumor growth and the development of cancer cachexia. Cancer Res., 51: 415-421, 1991.
8. Sherry, B. A., Gelin, J., Fong, Y., Marano, M., Wei, H., Cerami, A., Lowry, S. F., Lundholm, K. G., and Moldawer, L. L. Anticachectin/tumor necrosis factor a antibodies attenuate development of cachexia in tumor models. FASEB J., 3: 1956-1962, 1989.
9. Jenkins, D. C., Charles, I. G., Thomsen, L. L., Moss, D. W., Holmes, L. S., Baylis, S. A., Rhodes, P., Westmore, K., Emson, P. C., and Moncada, S. Roles of nitric oxide in tumor growth. Proc. Natl. Acad. Sci. USA, 92: 4392-4396, 1995.
10. Wilson, K. T., Fu, S., Ramanujam, K. S., and Meltzer, S. J. Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. Cancer Res., 58: 2929-2934, 1998.
11. Ambs, S., Merriam, W. G., Bennett, W. P., Felley-Bosco, E., Ogunfusika, M. O., Oser, S. M., Klein, S., Shields, P. G., Billiar, T. R., and Harris, C. C. Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression. Cancer Res., 58: 334-341, 1998.
12. Gallo, O., Masini, E., Morbidelli, L., Franchi, A., Fini-Storchi, I., Vergari, W. A., and Ziche, M. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer. J. Natl. Cancer Inst., 90: 587-596, 1998.
13. Dong, Z., Staroselsky, A. H., Qi, X., Xie, K., and Fidler, I. J. Inverse correlation between expression of inducibie nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells. Cancer Res., 54: 789-793, 1994.
14. Salvemini, D., Misko, T. P., Masferrer, J. L., Seibert, K., Currie, M. G., and Needleman, P. Nitric oxide activates cyclooxygenase enzymes. Proc. Natl. Acad. Sci. USA, 90: 7240-7244, 1993.
15. Salvemini, D., Seibert, K., Masferrer, J. L., Settle, S. L., Misko, T. P., Currie, M. G., and Needleman, P. Nitric oxide and the cyclooxygenase pathway. Adv. Prostaglandin Thromboxane Leukotriene Res., 23: 491-493, 1995.
16. Vane, J. R., Mitchell, J. A., Appleton, I., Tomlinson, A., Bishop-Bailey, D., Croxtall, J., and Willoughby, D. A. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc. Natl. Acad. Sci. USA, 91: 2046-2050, 1994.
17. Fukumura, D., and Jain, R. K. Role of nitric oxide in angiogenesis and microcirculation in tumors. Cancer Metastasis Rev., 17: 77-89, 1998.
18. Lundholm, K., Edstrom, S., Ekman, L., Karlberg, I., Bylund, A. C., and Schersten, T. A comparative study of the influence of malignant tumor on host metabolism in mice and man: evaluation of an experimental model. Cancer (Phila.), 42: 453-461, 1978.
19. Karlberg, I., Edstrom, S., Ekman, L., Johansson, S., Schersten, T., and Lundholm, K. Metabolic host reaction in response to the proliferation of nonmalignant cells versus malignant cells in vivo. Cancer Res., 41: 4154-4161, 1981.
20. Gelin, J., Andersson, C., and Lundholm, K. Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia. Cancer Res., 51: 880-885, 1991.
21. Xie, K., Wang, Y., Huang, S., Xu. L., Bielenberg, D., Salas, T., McConkey, D. J., Jiang, W., and Fidler, I. J. Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with down-regulation of Bcl-2. Oncogene, 15: 771-779, 1997.
22. Lundholm, K., Karlberg, I., Ekman, L., Edstrom, S., and Schersten, T. Evaluation of anorexia as the cause of altered protein synthesis in skeletal muscles from nongrowing mice with sarcoma. Cancer Res., 41: 1989-1996, 1981.
23. Eden, E., Lindmark, L., Karlberg, I., and Lundholm, K. Role of whole-body lipids and nitrogen as limiting factors for survival in tumor-bearing mice with anorexia and cachexia. Cancer Res., 43: 3707-3711, 1983.
24. Chan, C. C., Boyce, S., Brideau, C., Ford-Hutchinson, A. W., Gordon, R., Guay, D., Hill, R. G., Li, C. S., Mancini, J., Penneton, M., et al. Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach. J. Pharmacol. Exp. Ther., 274: 1531-1537, 1995.
25. Miller, M. J., Thompson, J. H., Zhang, X. J., Sadowska-Krowicka, H., Kakkis, J. L., Munshi, U. K., Sandoval, M., Rossi, J. L., Eloby-Childress, S., Beckman, J. S., et al. Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis. Gastroenterology, 109: 1475-1483, 1995.
26. Iuvone, T., Van Osselaer, N., D'Acquisto, F., Carnuccio, R., and Herman, A. G. Differential effect of L-NAME and S-methyl-isothiourea on leukocyte emigration in carrageenin-soaked sponge implants in rat. Br. J. Pharmacol., 121: 1637-1644, 1997.
27. Hedin, L., Gaddy-Kurten, D., Kurten, R., DeWitt, D. L., Smith, W. L., and Richards, J. S. Prostaglandin endoperoxide synthase in rat ovarian follicles: content, cellular distribution, and evidence for hormonal induction preceding ovulation. Endocrinology, 121: 722-731, 1987.
28. Lowry, O, H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193: 265-275, 1951.
29. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227: 680-685, 1970.
30. Bronstein, I., Voyta, J. C., Murphy, O. J., Bresnick, L., and Kricka, L. J. Improved chemiluminescent western blotting procedure. Biotechniques. 12: 748-753, 1992.
31. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanale-phenol-chloruform extraction. Anal. Biochem., 162: 156-159, 1987.
32. Henke, D. C., Kouzan, S., and Eling, T. E. Analysis of leukotrienes, prostaglandins, and other oxygenated metabolites of arachidonic acid by high-performance liquid chromatography. Anal. Biochem., 140: 87-94, 1984.
33. Lönnroth, C., Anderson, M., Iresjö, B-M., Karlsson, L., and Lundholm, K. Indomethacin influences on telomerase activity in tumor-bearing mice and cells in vitro. Miami Nature Biotechnology Short Reports, Vol. 10, Feb. 6-10, 1999.
34. Ogino, M., Hisatomi, H., and Hanazono, M. Effectiveness of indomethacin as an antitumor agent in Colon 26-bearing conventional and nude mice, and telomerase activity in the tumors. J. Exp. Anim. Sci., 48: 15-21, 1999.
35. Lala, P. K., Al-Mutler, N., and Orucevic, A. Effects of chronic indomethacin therapy on the development and progression of spontaneous mammary tumors in C3H/HEJ mice. Int. J. Cancer, 73: 371-380, 1997.
36. Lönnroth, C., Moldawer, L. L., Gelin, J., Kindblom, L., Sherry, B., and Lundholm, K. Tumor necrosis factor α and interleukin-1 α production in cachectic, tumor-bearing mice. Int. J. Cancer, 46: 889-896, 1990.
37. Hanif, R., Pittas, A., Feng, Y., Koutsos, M. I., Qiao, L., Staiano-Coico, L., Shiff, S. I., and Rigas, B. Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway. Biochem. Pharmacol., 52: 237-245, 1996.
38. Lu, X., Fairbairn, D. W., Bradshaw, W. S., O'Neill, K. L., Ewert, D. L., and Simmons, D. L. NSAID-induced apoptosis in Rous sarcoma virus-transformed chicken embryo fibroblasts is dependent on v-src and c-myc and is inhibited by bcl-2. Prostaglandins, 54: 549-568, 1997.
39. Hong, S. H., Avis, I., Vos, M. D., Martinez, A., Treston, A. M., and Mulshine, J. L. Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors. Cancer Res., 59: 2223-2228, 1999.
40. Dubois, R. N., Abramson, S. B., Crofford, L., Gupta, R. A., Simon, L. S., Van De Putte, L. B., and Lipsky, P. E. Cyclooxygenase in biology and disease. FASEB J., 12: 1063-1073, 1998.
41. Forrester, K., Ambs, S., Lupold, S. E., Kapust, R. B., Spillare, E. A., Weinberg, W. C., Felley-Bosco, E., Wang, X. W., Geller, D. A., Tzeng, E., Billiar, T. R., and Harris, C. C. Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. Proc. Natl. Acad. Sci. USA, 93: 2442-2447, 1996.
42. Chinje, E. C., and Stratford, I. J. Role of nitric oxide in growth of solid tumours: a balancing act. Essays Biochem., 32: 61-72, 1997.
43. Thomsen, L. L., and Miles, D. W. Role of nitric oxide in tumour progression: lessons from human tumours. Cancer Metastasis Rev., 17: 107-118, 1998.
44. Klotz, T., Bloch, W., Volberg, C., Engelmann, U., and Addicks, K. Selective expression of inducible nitric oxide synthase in human prostate carcinoma. Cancer (Phila.)., 82: 1897-1903, 1998.
45. Li, L. M., Kilbourn, R. G., Adams, J., and Fidler, I. J. Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells. Cancer Res., 51: 2531-2535, 1991.
46. Xie, K., Huang, S., Dong, Z., Juang, S. H., Gutman, M., Xie, Q. W., Nathan, C., and Fidler, I. J. Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells. J. Exp. Med. 181: 1333-1343, 1995.
47. Salvemini, D., Seibert, K., Masferrer, J. L. Misko, T. P., Currie, M. G., and Needleman, P. Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. J. Clin. Investig., 93: 1940-1947, 1994.
48. Tetsuka, T., Daphna-lken, D, Srivastava, S. K., Baier, L. D., DuMaine, J., and Morrison, A. R. Cross-talk between cyclooxygenase and nitric oxide pathways: prostaglandin E2 negatively modulates induction of nitric oxide synthase by interleukin 1. Proc Natl. Acad. Sci. USA, 91: 12168-12172, 1994
49. Salvemini, D., Manning, P. T., Zweifel, B. S., Seibert, K., Connor, J., Currie, M. G., Needleman, P., and Masferrer, J. L. Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors. J. Clin. Investig., 96: 301-308, 1995.
50. Brune, B., Sandau, K., and von Knethen, A. Apoptotic cell death and nitric oxide: activating and antagonistic transducing pathways. Biochemistry, 63: 817-825, 1998.
51. Salvemini, D. Regulation of cyclooxygenase enzymes by nitric oxide. Cell. Mol. Life Sci., 53: 576-582, 1997.
52. Kanematsu, M., Ikeda, K., and Yamada, Y. Interaction between nitric oxide synthase and cyclooxygenase pathways in osteoblastic MC3T3-E1 cells. J. Bone Miner. Res., 12: 1789-1796, 1997.
53. Elder, D. J., Halton, D. E., Hague, A., and Paraskeva, C. Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression Clin. Cancer Res., 3: 1679-1683, 1997.
54. Ambs, S., Ogunfusika, M. O., Merriam, W. G., Bennett, W. P., Billiar, T. R., and Harris, C. C. Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice. Proc. Nail. Acad. Sci. USA, 95: 8823-8828, 1998.
55. Chiarugi, V., Magnelli, L., and Gallo, O. Cox-2, iNOS, and p53 as play-makers of tumor angiogenesis. Int. J. Mol. Med., 2: 715-719, 1998.
56. Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., and Giaccia, A. J. Hypoxia-mediated selection of cells with diminished apopiotic potential in solid tumours. Nature (Lond.), 379: 88-91, 1996.
57. Lala, P. K. Significance of nitric oxide in carcinogenesis, tumor progression, and cancer therapy. Cancer Metastasis Rev., 17: 1-6, 1998.