Effectiveness of indomethacin as an antitumor agent in colon 26-bearing conventional and nude mice, and telomerase activity in the tumors

Experimental Animals

Volumn 48, Issue 1, 1999, Pages 15-21

  Ogino, Mitsuharu ^a   Hisatomi, Hisashi ^b   Hanazono, Makoto ^a  

^a TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SRL INC   (Japan)

Author keywords

Fluorescence based telomeric repeat amplification protocol (F TRAP); Indomethacin; Telomerase activity

Indexed keywords

MUS MUSCULUS;

ANTINEOPLASTIC AGENT; INDOMETACIN; TELOMERASE;

ADENOCARCINOMA; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CELL CULTURE; COLON; COLON TUMOR; ENZYMOLOGY; HUMAN; LIVER; MALE; METABOLISM; MOUSE; MOUSE STRAIN; NUDE MOUSE; TESTIS;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; COLON; COLONIC NEOPLASMS; HUMANS; INDOMETHACIN; LIVER; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED STRAINS; MICE, NUDE; TELOMERASE; TESTIS; TUMOR CELLS, CULTURED;

EID: 0032603041     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.48.15     Document Type: Article

References (21)

1. 2 production by monocyte is responsible for the depressed levels of natural killer and lymphokine-activated killer cell function in patients with breast cancer. Cancer 72: 491-501.
2. 2 analogue and indomethacin. Br. J. Cancer 52: 245-249.
3. Blackburn, E.H. 1991. Structure and function of telomeres. Nature 350: 569-573.
4. Blitzer, A. and Huang, C.C. 1983. The effect of indomethacin on the growth of epidermoid carcinoma of the palate in rats. Arch. Otolaryngol. 109: 719-723.
5. Bodnar, A.G., Ouellette, M., Frolkis, M., Holt, S.E., Chiu, C-P., Morin, G.B., Harley, C.B., Shay, J.W., Lichtsteiner, S., and Wright, W.E. 1998. Extension of life- span by introduction of telomerase into normal human cells. Science 279: 349-352.
6. Chadeneau, C., Hay, K., Hirte, H.W., Gallinger, S., and Bacchetti, S. 1995. Telomerase activity associated with acquisition of malignancy in human coloretal cancer. Cancer Res. 55: 2533-2536.
7. 2 induction of suppressor T lymphocytes. J. Immunol. 132: 1851-1857.
8. Counter, C.M., Avillion, A.A., LeFeuvre, C.E., Stewart, N.G., Greider, C.W., Harley, C.B., and Bacchetti, S. 1992. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO. J. 11: 1921-1929.
9. Cross, D.S., Platt, J.L., Juhn, S.K., Bach, F.H., and Adams, G.L. 1992. Administration of a prostaglandin synthetase inhibitor associated with an increased immune cell infiltrate in squamous cell carcinoma of the head and neck. Arch. Otolaryngol. Head Neck Sur. 118: 526-528.
10. 2 production by DTH-initiating factors. Cell Immunol. 137: 389-405.
11. Fulton, A.M. 1984. Effects of indomethacin on the growth of culture mammary tumors. Int. J. Cancer 33: 375-380.
12. Hisatomi, H., Nagao, K., and Komatsu, H. 1997. Quantification of telomerase activity in human liver tissues by fluorescence-based TRAP analysis. Hepatol. Res. 7: 36-42.
13. Hiyama, E., Yokoyama, T., Tatsumoto, N., Hiyama, K., Imamura, Y., Murakami, Y., Kodama, T., Piaztyszek, M.A., Shay, J.W., and Matsuura, Y. 1995. Telomerase activity in gastric cancer. Cancer Res. 55: 3258-3262.
14. Khoo, N.K.S., Chan, F.P.H., Saarloos, M.N., and Lala, P.K. 1992. Immunotherapy of mammary adenocarcinoma metastases in C3H/HeN mice with chronic administration of cyclo-oxygenase inhibitors alone or in combination with IL-2. Clin. Exp. Metastasis 10: 239-252.
15. Kim, N.W., Piatyszek, M.A., Prowse, K.R., Harley, C.B., West, M.D., Ho, P.L.C., Coviello, G.M., Wright, W.E., Weinrich, S.L., and Shay, J.W. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015.
16. Lala, P.K., Al-Mutter, N., and Orucevic, A. 1997. Effects of chronic indomethacin therapy on the development and progression of spontaneous mammary tumors in C3H/HeJ mice. Int. J. Cancer 73: 371-380.
17. Lala, P.K., Parhar, R.S., and Singh, P. 1986. Indomethacin therapy abrogates the prostaglandin-mediated suppression of natural killer activity in tumor bearing mice and prevents tumor metastasis. Cell Immunol. 99: 108-118.
18. Maca, R.D. 1988. Inhibition of the growth of Lewis lung carcinoma by indomethacin in conventional, nude and beige mice. J. Biol. Response Mod. 7: 568-580.
19. Maca, R.D., Burford, J.G., and Taylor, R.T. 1985. The effects of indomethacin and interleukin-2 on the proliferation of lymphocytes from patients with lung cancer. J. Clin. Immunol. 5: 158-165.
20. n among vertebrates. Proc. Natl. Acad. Sci. USA 86: 7049-7053.
21. Mori, H., Hanabayashi, T., Yamada, Y., and Tamaya, T. 1990. Decrease in interferone-γ production by peripheral blood mononuclear cells in patients with uterine cervical cancer. J. Clin. Immunol. 10: 45-51.