Induction of diabetes in nonobese diabetic mice by Th2 T cell clones from a TCR transgenic mouse

Journal of Immunology

Volumn 164, Issue 6, 2000, Pages 3072-3078

  Poulin, Michelle ^a   Haskins, Kathryn ^a,b  

^a UNIVERSITY OF COLORADO DENVER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CELL CLONE; CELL ISOLATION; CELL SPECIFICITY; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPRODUCIBILITY; TH2 CELL; TRANSGENE;

EID: 0034653472     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.6.3072     Document Type: Article

References (41)

1. Kikutani, H., and S. Makino. 1992. The murine autoimmune diabetes model: NOD and related strains. Adv. Immunol. 51:285.
2. Bach, J.-F. 1994. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr. Rev. 15:516.
3. Like, A. A., E. J. Weringer, A. Holdash, P. McGill, D. Atkinsor, and A. A. Rossini. 1985. Adoptive transfer of autoimmune diabetes mellitus in Biobreeding/Worcester (BB/W) inbred and hybrid rats. J. Immunol. 134:1583.
4. Harada, M., and S. Makino. 1986. Suppression of overt diabetes in NOD mice by anti-thymocyte serum or anti-thy 1.2 antibody. Exp. Anim. 35:501.
5. Wicker, L. S., B. J. Miller, and Y. Mullen. 1986. Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes 35:855.
6. Wang, Y., L. Hao, R. G. Gill, and K. J. Lafferty. 1987. Autoimmune diabetes in NOD mouse is L3T4 T-lymphocyte dependent. Diabetes 36:535.
7. Koike, T., Y. Itoh, T. Ishii, I. Ito, K. Takabayashi, N. Maruyama, H. Tomioka, and S. Yoshida. 1987. Preventive effect of monoclonal anti-L3T4 antibody on development of diabetes in NOD mice. Diabetes 36:539.
8. + T cells. J. Exp. Med. 166:823.
9. Shizuru, J. A., C. Taylor-Edwards, B. A. Banks, A. E. Gregory, and C. G. Fathman. 1988. Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to helper lymphocytes. Science 240:659.
10. 1 mice. Diabetes 37:252.
11. + T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J. Immunol. 140:52.
12. Haskins, K., M. Portas, B. Bradley, D. Wegmann, and K. Lafferty. 1988. T-lymphocyte clone specific for pancreatic islet antigen. Diabetes 37:1444.
13. Haskins, K., M. Portas, B. Bergman, K. Lafferty, and B. Bradley. 1989. Pancreatic islet-specific T-cell clones from nonobese diabetic mice. Proc. Natl. Acad. Sci. USA 86:8000.
14. + T-cell clones derived from lymphocytes infiltrating the islets of NOD mice. Diabetes 41:998.
15. Wegmann, D. R., N. Shehadeh, K. J. Lafferty, M. Norbury-Glaser, R. G. Gill, and D. Daniel. 1993. Establishment of islet-specific T-cell lines and clones from islet isografts placed in spontaneously diabetic NOD mice. J. Autoimmun. 6:517.
16. Wegmann, D. R., M. Norbury-Glaser, and D. Daniel. 1994. Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur. J. Immunol. 24:1853.
17. Gelber, C., L. Paborsky, S. Singer, D. McAteer, R. Tisch, C. Jolicoeur, R. Buelow, H. McDevitt, and C. G. Fathman. 1994. Isolation of nonobese diabetic mouse T-cells that recognize novel autoantigens involved in the early events of diabetes. Diabetes 43:33.
18. + Th1 and Th2 T cells derived from the spleens of diabetic NOD mice. J. Clin. Invest. 95:2979.
19. Wong, F. S., I. Visintin, L. Wen, R. A. Flavell, and C. A. Janeway. 1996. CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J. Exp. Med 183:67.
20. + islet-specific T cell clone. Science 249:1433.
21. Pancewycz, O., T. B. Strom, and V. E. Rubin-Kelley. 1991. Islet-infiltrating T cell clones from non-obese diabetic mice that promote or prevent accelerated diabetes. Eur. J. Immunol. 21:873.
22. + T cells of non-obese diabetic mice. J. Immunol. 151: 1723.
23. 1 mice. J. Immunol. 153:2800.
24. Daniel, D., R. G. Gill, N. Schloot, and D. Wegmann. 1995. Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur. J. Immunol. 25:1056.
25. Bergman, B., and K. Haskins. 1997. Autoreactive T-cell clones from the nonobese diabetic mouse. Proc. Soc. Exp. Biol. Med. 214:41.
26. Katz, J. D., B. Wang, K. Haskins, C. Benoist, and D. Mathis. 1993. Following a diabetogenic T cell from genesis through pathogenesis. Cell 74:1089.
27. Bergman, B., and K. Haskins. 1994. Islet-specific T cell clones from the NOD mouse respond to β granule antigen. Diabetes 43:197.
28. Kurrer, M. O., S. V. Pakala, H. L. Hanson, and J. D. Katz. 1997. β Cell apoptosis in T cell-mediated autoimmune disease. Proc. Natl. Acad. Sci. USA 94:213.
29. Rapoport, M. J., A. Jaramillo, D. Zipris, A. H. Lazarus, D. V. Serreze, E. H. Leiter, P. Cyopick, J. S. Danska, and T. L. Delovitch. 1993. Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med. 178:87.
30. Cameron, M. J., G. A. Arreaza, P. Zucker, S. W. Chensue, R. M. Strieter, S. Chakrabarti, and T. L. Delovitch. 1997. IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function. J. Immunol. 159:4686.
31. Mueller, R., T. Krahl, and N. Sarvetnick. 1996. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice. J. Exp. Med. 184:1093.
32. Pennline, K. J., E. Roque-Gaffney, and M. Monahan. 1994. Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin. Immunol. Immunopathol. 71:169.
33. Katz, J. D., C. Benoist, and D. Mathis. 1995. T helper cell subsets in insulin-dependent diabetes. Science 268:1185.
34. Pakala, S. V., M. O. Kurrer, and J. D. Katz. 1997. T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice. J. Exp. Med 186:299.
35. Karasuyama, H., and F. Melchers. 1988. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur. J. Immunol. 18:97.
36. Bradley, L. M., V. C. Asensio, L. K. Schioetz, J. Harbertson, T. Krahl, G. Patstone, N. Woolf, I. L. Campbell, and N. Sarvetnick. 1999. Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes. J. Immunol. 162:2511.
37. Perez, V. L., J. A. Lederer, A. H. Lichtman, and A. K. Abbas. 1995. Stability of Th1 and Th2 populations. Int. Immunol. 7:869.
38. Murphy, E., K. Shibuya, N. Hosken, P. Openshaw, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1996. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J. Exp. Med. 183:901.
39. + T cells, interleukin 4 is cytokine-autonomous, whereas interferon γ production is cytokine-dependent. Proc. Natl. Acad. Sci. USA 94:3189.
40. Tisch, R., B. Wang, and D. V. Serreze. 1999. Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent. J. Immunol. 163:1178.
41. Gallichan, W. S., B. Balasa, J. D. Davies, and N. Sarvetnick. 1999. Pancreatic IL-4 expression results in islet-reactive Th2 cells that inhibit diabetogenic lymphocytes in the nonobese diabetic mouse. J. Immunol. 163:1696.