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0343482175
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The acetal 11 was prepared from 1-chloro-2-methoxymethoxy-4-nitrobenzene by the following sequence of reaction: (1) nucleophilic substitution with the carbanion derived from methyl phenylacetate; (2) reduction of the nitro group; (3) dibenzylation of the amino group formed; (4) reduction of the ester to an aldehyde by DIBAL-H; (5) acid-catalyzed acetalization in methanol; and (6) deprotection of the dibenzylamino group.
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The acetal 11 was prepared from 1-chloro-2-methoxymethoxy-4-nitrobenzene by the following sequence of reaction: (1) nucleophilic substitution with the carbanion derived from methyl phenylacetate; (2) reduction of the nitro group; (3) dibenzylation of the amino group formed; (4) reduction of the ester to an aldehyde by DIBAL-H; (5) acid-catalyzed acetalization in methanol; and (6) deprotection of the dibenzylamino group.
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0342612188
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All new compounds were characterized fully by spectroscopy and high-resolution mass spectra.
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All new compounds were characterized fully by spectroscopy and high-resolution mass spectra.
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