Functional specificity conferred by the unique plasticity of fully α-helical Ras and Rho GAPs

FEBS Letters

Volumn 477, Issue 1-2, 2000, Pages 99-105

  Souchet, Michel ^a   Poupon, Anne ^b   Callebaut, Isabelle ^c   Léger, Isabelle ^a   Mornon, Jean Paul ^c   Bril, Antoine ^a   Calmels, Thierry P G ^a  

^a SmithKline Beecham   (France)

^b CEA SACLAY   (France)

^c UNIVERSITÉ PIERRE ET MARIE CURIE   (France)

Author keywords

Four helix bundle; GTPase activating protein; Plasticity; Ras; Rho

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN P120; PROTEIN P50; RAS PROTEIN; RHO FACTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BINDING SITES; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; GTPASE-ACTIVATING PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; P120 GTPASE ACTIVATING PROTEIN; PLIABILITY; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RAS PROTEINS; RHO GTP-BINDING PROTEINS; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

EID: 0034647989     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(00)01769-5     Document Type: Article

References (22)

1. Scheffzek K., Lautwein A., Kabsch W., Ahmadian M.R., Wittinghofer A. Nature. 384:1996;591-596.
2. Barrett T., Xiao B., Dodson E.J., Dodson G., Ludbrook S.B., Nurmahomed K., Gamblin S.J., Musacchio A., Smerdon S.J., Eccleston J.F. Nature. 385:1997;458-461.
3. Scheffzek K., Ahmadian M.R., Wittinghofer A. Trends Biochem. Sci. 23:1998;257-262.
4. Scheffzek K., Ahmadian M.R., Kabsch W., Wiesmüller L., Lautwein A., Schmitz F., Wittinghofer A. Science. 277:1997;333-338.
5. Rittinger K., Walker P.A., Eccleston J.F., Smerdon S.J., Gamblin S.J. Nature. 389:1997;758-762.
6. Bax B. Nature. 392:1998;447-448.
7. Calmels T.P.G., Callebaut I., Léger I., Durand P., Bril A., Mornon J.P., Souchet M. FEBS Lett. 426:1998;205-211.
8. Rittinger K., Taylor W.R., Smerdon S.J., Gamblin S.J. Nature. 392:1998;448-449.
9. Callebaut I., Labesse G., Durand P., Poupon A., Canard L., Chomilier J., Henrissat B., Mornon J.P. Cell. Mol. Life Sci. 53:1997;621-645.
10. Girault J.A., Labesse G., Mornon J.-P., Callebaut I. Trends Biochem. Sci. 24:1999;54-57.
11. Callebaut I., Courvalin J.C., Mornon J.P. FEBS Lett. 446:1999;189-193.
12. Wojcik J., Girault J.A., Labesse G., Chomilier J., Mornon J.P., Callebaut I. Biochem. Biophys. Res. Commun. 259:1999;113-120.
13. Gouet P., Courcelle E., Stuart D.I., Metoz F. Bioinformatics. 15:1999;305-308.
14. Poupon A., Mornon J.P. Proteins. 33:1998;329-342.
15. Lee B.K., Richards F.M. J. Mol. Biol. 112:1971;379-400.
16. Kamtekar S., Hecht M.H. FASEB J. 9:1995;1013-1022.
17. Poupon A., Mornon J.P. FEBS Lett. 452:1999;283-289.
18. Bowie J.U. Nat. Struct. Biol. 4:1997;915-917.
19. Glykos N.M., Cesareni G., Kokkinidis M. Struct. Fold. Des. 7:1999;597-603.
20. Blondel A., Renaud J.P., Fischer S., Moras D., Karplus M. J. Mol. Biol. 291:1999;101-115.
21. Locher K.P., Rees B., Koebnik R., Mitschler A., Moulinier L., Rosenbusch J.P., Moras D. Cell. 95:1998;771-778.
22. Bullough P.A., Hughson F.M., Skehel J.J., Wiley D.C. Nature. 371:1994;37-43.