Stay the executioner's hand

Science

Volumn 288, Issue 5464, 2000, Pages 283-284

  Gurney, Mark E ^a   Tomasselli, Alfredo G ^a   Hainrikson, Robert L ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE INHIBITOR; COPPER ZINC SUPEROXIDE DISMUTASE; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MUTANT PROTEIN; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASP3 PROTEIN, HUMAN; CASP3 PROTEIN, MOUSE; CASPASE; CYSTEINE PROTEINASE INHIBITOR; INTERLEUKIN 1; NEUROPROTECTIVE AGENT; PEPTIDE CHLOROMETHYL KETONE; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; GENE MUTATION; HUMAN; MOTOR NEURON DISEASE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; SHORT SURVEY; ANIMAL; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; MOTONEURON; MOUSE; NOTE; PATHOLOGY; SPINAL CORD; TRANSGENIC MOUSE;

AMINO ACID CHLOROMETHYL KETONES; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; APOPTOSIS; CASPASE 1; CASPASE 3; CASPASES; CYSTEINE PROTEINASE INHIBITORS; DISEASE MODELS, ANIMAL; HUMANS; INTERLEUKIN-1; MICE; MICE, TRANSGENIC; MOTOR NEURONS; NEUROPROTECTIVE AGENTS; SPINAL CORD; SUPEROXIDE DISMUTASE;

EID: 0034647034     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.288.5464.283     Document Type: Short Survey

References (11)

1. D. R. Rosen et al., Nature 362, 59 (1993).
2. M. E. Gurney et al., Science 264, 1772 (1994).
3. P. C. Wong et al., Neuron 14, 1105 (1995).
4. D. W. Cleveland, Neuron 24, 515 (1999).
5. M. Li et al., Science 288, 335 (2000).
6. V. Kostic et al., Science 277, 559 (1997).
7. D. R. Green and J. C. Reed, Science 281, 1309 (1998).
8. R. M. Friedlander et al., Nature 388, 31 (1997).
9. N. A. Thornberry and Y. Lazebnik, Science 281, 1312 (1998).
10. L. J. Martin, J. Neuropathol. Exp. Neurol. 58, 459 (1999).
11. P. Pasinelli et al., Proc. Natl. Acad. Sci. U.S.A. 95, 15763 (1998).