HIV type 1 nef gene inhibits tumor necrosis factor α-induced apoptosis and promotes cell proliferation through the action of MAPK and JNK in human glial cells

AIDS Research and Human Retroviruses

Volumn 16, Issue 18, 2000, Pages 1959-1965

  Robichaud, G A ^a,b   Poulin, L ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; ASTROCYTOSIS; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; GLIA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; VIRUS GENE;

EID: 0034634912     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/088922200750054684     Document Type: Article

References (26)

1. Neurological complications in infants and children with acquired immune deficiency syndrome
2. The brain in AIDS: Central nervous system HIV-1 infection and AIDS dementia complex
3. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients
4. TNF-alpha potentiates glutamate neurotoxicity in human fetal brain cell cultures
5. HIV-1 infection of the developing nervous system: Central role of astrocytes in pathogenesis
6. Astrocytes in infections and immune-mediated diseases of the central nervous system
7. Unraveling the neuroimmune mechanisms for the HIV-1-associated cognitive/motor complex
8. Infection of human brain cells by HIV-1: Restricted virus production in chronically infected human glial cell lines
9. Human immunodeficiency virus type 1 infection of the brain
10. Abundant expression of Nef and Rev Proteins in brain astrocytes in vivo is associated with dementia
11. HIV-1 infection of subcortical astrocytes in the pediatric central nervous system
12. HIV-1 Nef binds directly to Lck and mitogen-activated protein kinase inhibiting kinase activity
13. Interference of HIV-1 Nef in the sphingomyelin transduction pathway activated by tumour necrosis factor-alpha in human glial cells
14. Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions
15. The Nef protein associates with protein kinase C theta
16. Isolates of human immunodeficiency virus type 1 from the brain may constitute a special group of the AIDS virus
17. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
18. Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes
19. The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase
20. Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase
21. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
22. Ceramide activates the stress-activated protein kinases
23. HIV-1 Nef attenuates Fas- and TNF-α-induced apoptosis by inhibiting apoptosis-signal regulating kinase-1 (ASK1): Potential role in prolonging survival of the HIV-1-infected cell
24. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
25. Programmed cell death induced by ceramide
26. Human immunodeficiency virus type-1 Nef protein sensitizes CD4+ T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway