Improved binding of cytochrome P450cam substrate analogues designed to fill extra space in the substrate binding pocket

Biochemistry

Volumn 35, Issue 5, 1996, Pages 1485-1499

  Helms, Volkhard ^a   Deprez, Eric ^b   Gill, Edward ^c   Barret, Christel ^b   Hoa, Gaston Hui Bon ^b   Wade, Rebecca C ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b INST DE BIOLOGIE PHYSICO CHIMIQUE   (France)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPHOR; CAMPHOR DERIVATIVE; CYTOCHROME P450;

ARTICLE; BINDING AFFINITY; DISSOCIATION CONSTANT; ENTHALPY; ENTROPY; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; MOLECULAR DYNAMICS; PRIORITY JOURNAL; THERMODYNAMICS;

BINDING SITES; BORNANES; CAMPHOR; CAMPHOR 5-MONOOXYGENASE; COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; HYDROGEN BONDING; LIGANDS; MIXED FUNCTION OXYGENASES; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; THERMODYNAMICS;

DRYOBALANOPS;

EID: 0030040103     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi951817l     Document Type: Article

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