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Volumn 11, Issue SUPPL. 3, 1996, Pages 133-147

Dose relationship between GnRH antagonists and pituitary suppression

Author keywords

Acyline; Azaline B; Betidamino acids; Drug design; GnRH antagonists

Indexed keywords

BUFFER; GONADORELIN AGONIST; GONADORELIN ANTAGONIST; HISTAMINE;

EID: 13144281714     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/11.suppl_3.133     Document Type: Conference Paper
Times cited : (19)

References (74)
  • 1
    • 0027250374 scopus 로고
    • Comparison of a gonadotrophin releasing-hormone antagonist plus testosterone (T) versus T alone as potential male contraceptive regimens
    • Bagatell, C.J., Matsumoto, A.M., Christensen, R.B. et al. (1993) Comparison of a gonadotrophin releasing-hormone antagonist plus testosterone (T) versus T alone as potential male contraceptive regimens. J. Clin. Endocrinol. Metab., 77, 427-432.
    • (1993) J. Clin. Endocrinol. Metab. , vol.77 , pp. 427-432
    • Bagatell, C.J.1    Matsumoto, A.M.2    Christensen, R.B.3
  • 2
    • 0028964109 scopus 로고
    • Hormonal regulation of endometriosis and the rationales and effects of gonadotrophin-releasing hormone agonist treatment: A review
    • Bergqvist, I.A. (1995) Hormonal regulation of endometriosis and the rationales and effects of gonadotrophin-releasing hormone agonist treatment: a review. Hum. Reprod., 10, 446-452.
    • (1995) Hum. Reprod. , vol.10 , pp. 446-452
    • Bergqvist, I.A.1
  • 3
    • 0022445568 scopus 로고
    • Hormonal effects of Ketoconazole in vivo in the male rat: Mechanism of action
    • Bhasin, S., Sikka, S., Fielder, T. et al. (1986) Hormonal effects of Ketoconazole in vivo in the male rat: mechanism of action. Endocrinology, 118, 1229-1232.
    • (1986) Endocrinology , vol.118 , pp. 1229-1232
    • Bhasin, S.1    Sikka, S.2    Fielder, T.3
  • 4
    • 0027436493 scopus 로고
    • Conformational analysis of a highly potent dicyclic gonadotropin-releasing hormone antagonist by nuclear magnetic resonance and molecular dynamics
    • Bienstock, R.J., Rizo, J., Koerber, S.C. et al. (1993) Conformational analysis of a highly potent dicyclic gonadotropin-releasing hormone antagonist by nuclear magnetic resonance and molecular dynamics. J. Med. Chem., 36, 3265-3273.
    • (1993) J. Med. Chem. , vol.36 , pp. 3265-3273
    • Bienstock, R.J.1    Rizo, J.2    Koerber, S.C.3
  • 5
    • 0027724267 scopus 로고
    • Development of 1,4-benzodiazepine cholecystokinin type B antagonists
    • Bock, M.G., DiPardo, R.M., Evans, B.E. et al. (1993) Development of 1,4-benzodiazepine cholecystokinin type B antagonists. J. Med. Chem., 36, 4276-4292.
    • (1993) J. Med. Chem. , vol.36 , pp. 4276-4292
    • Bock, M.G.1    DiPardo, R.M.2    Evans, B.E.3
  • 6
    • 0024529827 scopus 로고
    • Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260
    • Bock, M.G., DiPardo, R.M., Evans, B.E. et al. (1989) Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260. J. Med. Chem., 32, 13-16.
    • (1989) J. Med. Chem. , vol.32 , pp. 13-16
    • Bock, M.G.1    DiPardo, R.M.2    Evans, B.E.3
  • 7
    • 0029059085 scopus 로고
    • Potent pituitary-gonadal axis suppression and extremely low anaphylactoid activity of a new gonadotrophin releasing hormone (GnRH) receptor antagonist 'Azaline B'
    • Campen, C.A., Lai, M.-T., Kraft, P. et al. (1995) Potent pituitary-gonadal axis suppression and extremely low anaphylactoid activity of a new gonadotrophin releasing hormone (GnRH) receptor antagonist 'Azaline B'. Biochem. Pharmacol., 49, 1313-1321.
    • (1995) Biochem. Pharmacol. , vol.49 , pp. 1313-1321
    • Campen, C.A.1    Lai, M.-T.2    Kraft, P.3
  • 9
    • 0022447490 scopus 로고
    • Molecular conformation of gonadoliberin using two-dimensional NMR spectroscopy
    • Chary, V.R., Srivastava, S., Hosur, R.V. et al. (1986) Molecular conformation of gonadoliberin using two-dimensional NMR spectroscopy. Eur. J. Biochem., 158, 323-332.
    • (1986) Eur. J. Biochem. , vol.158 , pp. 323-332
    • Chary, V.R.1    Srivastava, S.2    Hosur, R.V.3
  • 10
    • 0025287609 scopus 로고
    • Inhibition of follicle-stimulating hormone secretion from gonadotroph adenomas by repetitive administration of a GnRH antagonist
    • Daneshdoost, L., Pavlou, S.N., Molich, M.E. et al. (1990) Inhibition of follicle-stimulating hormone secretion from gonadotroph adenomas by repetitive administration of a GnRH antagonist. J. Clin. Endocrinol. Metab., 71, 92-97.
    • (1990) J. Clin. Endocrinol. Metab. , vol.71 , pp. 92-97
    • Daneshdoost, L.1    Pavlou, S.N.2    Molich, M.E.3
  • 11
    • 0024452507 scopus 로고
    • LH-RH antagonists: Design and synthesis of a novel series of peptidomimetics
    • De, B., Plattner, J.J., Bush, E.N. et al. (1989) LH-RH antagonists: design and synthesis of a novel series of peptidomimetics. J. Med. Chem., 32, 2036-2038.
    • (1989) J. Med. Chem. , vol.32 , pp. 2036-2038
    • De, B.1    Plattner, J.J.2    Bush, E.N.3
  • 12
    • 0016774381 scopus 로고
    • Conformational flexibility of luteinizing hormone-releasing hormone in aqueous solution. A carbon-13 spin-lattice relaxation time study
    • Deslauriers, R., Levy, G.C., McGregor, W.H. et al. (1975) Conformational flexibility of luteinizing hormone-releasing hormone in aqueous solution. A carbon-13 spin-lattice relaxation time study. Biochemistry, 14, 4335-4343.
    • (1975) Biochemistry , vol.14 , pp. 4335-4343
    • Deslauriers, R.1    Levy, G.C.2    McGregor, W.H.3
  • 13
    • 0027757114 scopus 로고
    • Non-peptide angiotensin II receptor antagonists. I. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles
    • Dhanoa, D.S., Bagley, S.W., Chang, R.S.L. et al. (1993a) Non-peptide angiotensin II receptor antagonists. I. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles. J. Med. Chem., 36, 4230-4238.
    • (1993) J. Med. Chem. , vol.36 , pp. 4230-4238
    • Dhanoa, D.S.1    Bagley, S.W.2    Chang, R.S.L.3
  • 14
    • 0027732198 scopus 로고
    • Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis and biological activity of N-substituted (Phenylamino) phenylacetic acids and acyl sulfonamides
    • Dhanoa, D.S., Bagley, S.W., Chang, R.S.L. et al. (1993b) Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis and biological activity of N-substituted (Phenylamino) phenylacetic acids and acyl sulfonamides. J. Med. Chem., 36, 4239-4249.
    • (1993) J. Med. Chem. , vol.36 , pp. 4239-4249
    • Dhanoa, D.S.1    Bagley, S.W.2    Chang, R.S.L.3
  • 15
    • 0026343588 scopus 로고
    • The gonadotropin-releasing hormone antagonist (Nal-Glu) acutely blocks the luteinizing hormone surge but allows for resumption of folliculogenesis in normal women
    • Ditkoff, E.C., Cassidenti, D.L., Paulson, R.J. et al. (1992) The gonadotropin-releasing hormone antagonist (Nal-Glu) acutely blocks the luteinizing hormone surge but allows for resumption of folliculogenesis in normal women. Am. J. Obstet. Gynecol., 165, 1811-1817.
    • (1992) Am. J. Obstet. Gynecol. , vol.165 , pp. 1811-1817
    • Ditkoff, E.C.1    Cassidenti, D.L.2    Paulson, R.J.3
  • 16
    • 0023850131 scopus 로고
    • Luteinizing hormone-releasing hormone (LHRH) antagonists
    • Dutta, A.S. (1988) Luteinizing hormone-releasing hormone (LHRH) antagonists. Drugs of the Future, 13, 43-57.
    • (1988) Drugs of the Future , vol.13 , pp. 43-57
    • Dutta, A.S.1
  • 17
    • 0026443104 scopus 로고
    • Orally active, nonpeptide oxytocin antagonists
    • Evans, B.E., Leighton, J.L., Rittle, K.E. et al. (1992) Orally active, nonpeptide oxytocin antagonists. J. Med. Chem., 35, 3919-3927.
    • (1992) J. Med. Chem. , vol.35 , pp. 3919-3927
    • Evans, B.E.1    Leighton, J.L.2    Rittle, K.E.3
  • 18
    • 0027768641 scopus 로고
    • Nanomolar-affinity, non-peptide oxytocin receptor antagonists
    • Evans, B.E., Lundell, G.F., Gilbert, K.F. et al. (1993) Nanomolar-affinity, non-peptide oxytocin receptor antagonists. J. Med. Chem., 36, 3993-4005.
    • (1993) J. Med. Chem. , vol.36 , pp. 3993-4005
    • Evans, B.E.1    Lundell, G.F.2    Gilbert, K.F.3
  • 19
    • 0019163001 scopus 로고
    • Bioactive conformation of luteinizing hormone-releasing hormone: Evidence from a conformationally constrained analog
    • Freidinger, R.M., Veber, D.F., Perlow, D.S. et al. (1980) Bioactive conformation of luteinizing hormone-releasing hormone: evidence from a conformationally constrained analog. Science. 210, 656-658.
    • (1980) Science , vol.210 , pp. 656-658
    • Freidinger, R.M.1    Veber, D.F.2    Perlow, D.S.3
  • 20
    • 0027994194 scopus 로고
    • Inhibition of luteinizing hormone. follicle-stimulating hormone and sex-steroid levels in men and women with a potent antagonist analog of luteinizing hormone-releasing hormone, Cetrorelix (SB-75)
    • Gonzalez-Barcena, D., Buenfil, M.V., Procel, E.G. et al. (1994) Inhibition of luteinizing hormone. follicle-stimulating hormone and sex-steroid levels in men and women with a potent antagonist analog of luteinizing hormone-releasing hormone, Cetrorelix (SB-75). Eur. J. Endocrinol. 131, 286-292.
    • (1994) Eur. J. Endocrinol. , vol.131 , pp. 286-292
    • Gonzalez-Barcena, D.1    Buenfil, M.V.2    Procel, E.G.3
  • 21
    • 0027287518 scopus 로고
    • A novel computer modeling approach to the structures of small bioactive peptides: The structure of gonadotrophin releasing hormone
    • Gupta, H.M., Talwar, G.P. and Salunke, D.M. (1993) A novel computer modeling approach to the structures of small bioactive peptides: the structure of gonadotrophin releasing hormone. Proteins: Structure, Function and Genetics, 16, 48-56.
    • (1993) Proteins: Structure, Function and Genetics , vol.16 , pp. 48-56
    • Gupta, H.M.1    Talwar, G.P.2    Salunke, D.M.3
  • 22
    • 0025825564 scopus 로고
    • Variable tolerance of the developing follicle and corpus luteum to GnRH antagonist-induced gonadotrophin withdrawal in the human
    • Hall, J.E., Bhatta, N., Adams, J.M. et al. (1990) Variable tolerance of the developing follicle and corpus luteum to GnRH antagonist-induced gonadotrophin withdrawal in the human. J. Clin. Endocrinol. Metab., 72, 993-1000.
    • (1990) J. Clin. Endocrinol. Metab. , vol.72 , pp. 993-1000
    • Hall, J.E.1    Bhatta, N.2    Adams, J.M.3
  • 23
    • 0027340065 scopus 로고
    • The effect of NMeTyrS substitution in luteinizing hormone-releasing hormone antagonists
    • Haviv, F., Fitzpatrick, T.D., Nichols, C.J. et al. (1993) The effect of NMeTyrS substitution in luteinizing hormone-releasing hormone antagonists. J. Med. Chem., 36, 928-933.
    • (1993) J. Med. Chem. , vol.36 , pp. 928-933
    • Haviv, F.1    Fitzpatrick, T.D.2    Nichols, C.J.3
  • 25
    • 0007097512 scopus 로고
    • An overview of GnRH antagonists development: Two decades of progress
    • Crowley, W.F. Jr and Conn, P.M. (eds), Springer Verlag, New York
    • Karten, M.J. (1992) An overview of GnRH antagonists development: two decades of progress, In Crowley, W.F. Jr and Conn, P.M. (eds), Modes of Action of GnRH and GnRH Analogs. Springer Verlag, New York, pp. 277-297.
    • (1992) Modes of Action of GnRH and GnRH Analogs , pp. 277-297
    • Karten, M.J.1
  • 26
    • 0000400728 scopus 로고
    • The development of safer GnRH antagonists: Strategy and status
    • Bouchard, P., Haour, F., Franchimont, P. and Schatz, B. (eds). Elsevier, Paris. France
    • Karten, M.J., Hoeger, C.A., Hook, W.A. et al. (1990) The development of safer GnRH antagonists: strategy and status. In Bouchard, P., Haour, F., Franchimont, P. and Schatz, B. (eds). Recent Progress on GnRH and Gonadal Peptides. Elsevier, Paris. France, pp. 147-158.
    • (1990) Recent Progress on GnRH and Gonadal Peptides , pp. 147-158
    • Karten, M.J.1    Hoeger, C.A.2    Hook, W.A.3
  • 27
    • 9844260551 scopus 로고
    • In vitro histamine release with LHRH analogs
    • Vickery, B.H. and J.J. Nestor, J. (eds), MTP Press Ltd., Lancaster, Boston, The Hague
    • Karten, M.J., Hook, W.A., Siraganian, R.P. et al. (1987) In vitro histamine release with LHRH analogs. In Vickery, B.H. and J.J. Nestor, J. (eds), LHRH and Its Analogs, Contraceptive and Therapeutic Applications, Part 2. MTP Press Ltd., Lancaster, Boston, The Hague, pp. 179-190.
    • (1987) LHRH and Its Analogs, Contraceptive and Therapeutic Applications , Issue.2 PART , pp. 179-190
    • Karten, M.J.1    Hook, W.A.2    Siraganian, R.P.3
  • 29
    • 0000015666 scopus 로고
    • Benzotriazole-assisted synthesis of monoacyl aminals and their peptide derivatives
    • Katritzky, A.R., Urogdi, L. and Mayence, A. (1990) Benzotriazole-assisted synthesis of monoacyl aminals and their peptide derivatives. J. Org. Chem., 55, 2206-2214.
    • (1990) J. Org. Chem. , vol.55 , pp. 2206-2214
    • Katritzky, A.R.1    Urogdi, L.2    Mayence, A.3
  • 30
    • 13144276657 scopus 로고
    • Structure of luteinizing hormone-releasing hormone bound to perdeuterated dodecylphosphocholine micelles as studies by 2D-NMR
    • Kawaguchi, K., Maruyama, T., Terasawa, I. et al. (1989) Structure of luteinizing hormone-releasing hormone bound to perdeuterated dodecylphosphocholine micelles as studies by 2D-NMR. Peptide Chem., 337-340.
    • (1989) Peptide Chem. , pp. 337-340
    • Kawaguchi, K.1    Maruyama, T.2    Terasawa, I.3
  • 31
    • 0027485121 scopus 로고
    • Rapid regression of uterine leiomyoma in response to long-term daily administration of GnRH antagonist
    • Kettel, L.M., Murphy, A.A., Morales, A.J. et al. (1993) Rapid regression of uterine leiomyoma in response to long-term daily administration of GnRH antagonist. Fertil. Steril., 60, 642-646.
    • (1993) Fertil. Steril. , vol.60 , pp. 642-646
    • Kettel, L.M.1    Murphy, A.A.2    Morales, A.J.3
  • 32
    • 0026702302 scopus 로고
    • Abrogation by a potent gonadotropin-releasing hormone antagonist of the estrogen progesterone-stimulated surge-like release of luteinizing hormone and follicle-stimulating hormone in postmenopausal women
    • Kolp, L.A., Pavlou, S.N., Urban, R.J. et al. (1992) Abrogation by a potent gonadotropin-releasing hormone antagonist of the estrogen progesterone-stimulated surge-like release of luteinizing hormone and follicle-stimulating hormone in postmenopausal women. J. Clin. Endocrinol. Metab., 75, 993-997.
    • (1992) J. Clin. Endocrinol. Metab. , vol.75 , pp. 993-997
    • Kolp, L.A.1    Pavlou, S.N.2    Urban, R.J.3
  • 33
    • 4544284332 scopus 로고
    • On the location of β-turns
    • Kopple, K.D. (1981) On the location of β-turns. Biopolymers, 20, 1913-1920.
    • (1981) Biopolymers , vol.20 , pp. 1913-1920
    • Kopple, K.D.1
  • 34
    • 0020646967 scopus 로고
    • Nitroxyl-induced T1 relaxation rates as a probe of conformation in peptide hormones
    • Kopple, K.D. (1983a) Nitroxyl-induced T1 relaxation rates as a probe of conformation in peptide hormones. Int. J. Pept. Protein Res., 21, 43-48.
    • (1983) Int. J. Pept. Protein Res. , vol.21 , pp. 43-48
    • Kopple, K.D.1
  • 35
    • 0011809043 scopus 로고
    • Peptide backbone folding in LHRH and analogs
    • Rich, D.H. and Gross, E. (eds), University of Wisconsin, Madison/Pierce Chemical Co, Rockford, IL
    • Kopple, K.D. (1983b) Peptide backbone folding in LHRH and analogs. In Rich, D.H. and Gross, E. (eds), Peptides: Synthesis-Structure-Function, University of Wisconsin, Madison/Pierce Chemical Co, Rockford, IL, pp. 295-298.
    • (1983) Peptides: Synthesis-Structure-Function , pp. 295-298
    • Kopple, K.D.1
  • 37
    • 0025360653 scopus 로고
    • Antagonists of LHRH superior to amide: Effective sequence/activity relationships
    • Ljungqvist, A., Feng, D.-M., Bowers, C. et al. (1990) Antagonists of LHRH superior to amide: effective sequence/activity relationships. Tetrahedron, 46, 3297-3304.
    • (1990) Tetrahedron , vol.46 , pp. 3297-3304
    • Ljungqvist, A.1    Feng, D.-M.2    Bowers, C.3
  • 38
    • 0006368472 scopus 로고
    • Antide and related antagonists of luteinizing hormone release with long action and oral activity
    • Ljungqvist, A., Feng, D.-M., Hook, W. et al (1988) Antide and related antagonists of luteinizing hormone release with long action and oral activity. Proc. Natl Acad. Sci. USA. 85, 8236-8240.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 8236-8240
    • Ljungqvist, A.1    Feng, D.-M.2    Hook, W.3
  • 39
    • 0023640179 scopus 로고
    • Design, synthesis and bioassays of antagonists of LHRH which have high antiovulatory activity and release negligible histamine
    • Ljungqvist, A., Feng, D.-M., Tang, P.-F.L. et al. (1987) Design, synthesis and bioassays of antagonists of LHRH which have high antiovulatory activity and release negligible histamine. Biochem. Biophys. Res. Commun., 148, 849-856.
    • (1987) Biochem. Biophys. Res. Commun. , vol.148 , pp. 849-856
    • Ljungqvist, A.1    Feng, D.-M.2    Tang, P.-F.L.3
  • 40
    • 0026695818 scopus 로고
    • The discovery of (2S,3S)-cis-2-(Diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]- octan-3-amine as a novel. nonpeptide substance P antagonist
    • Lowe, J.A., III, Drozda, S.E., Snider, R.M. et al. (1992) The discovery of (2S,3S)-cis-2-(Diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]- octan-3-amine as a novel. nonpeptide substance P antagonist. J. Med. Chem., 35, 2591-2600.
    • (1992) J. Med. Chem. , vol.35 , pp. 2591-2600
    • Lowe III, J.A.1    Drozda, S.E.2    Snider, R.M.3
  • 42
    • 0027168684 scopus 로고
    • New technique for quantitation of pituitary adenoma size: Use in evaluating treatment of gonadotroph adenomas with a GnRH antagonist
    • McGrath, G.A., Goncalvez, R., Udupa, J. et al. (1992) New technique for quantitation of pituitary adenoma size: use in evaluating treatment of gonadotroph adenomas with a GnRH antagonist. J. Clin. Endocrinol. Metab., 76, 1363-1368.
    • (1992) J. Clin. Endocrinol. Metab. , vol.76 , pp. 1363-1368
    • McGrath, G.A.1    Goncalvez, R.2    Udupa, J.3
  • 43
    • 0017128446 scopus 로고
    • Confbrmational energy analysis of the molecule, luteinizing hormone-releasing hormone. 1. Native decapeptide
    • Momany, F.A. (1976a) Confbrmational energy analysis of the molecule, luteinizing hormone-releasing hormone. 1. Native decapeptide. J. Am. Chem. Soc., 98, 2990-2996.
    • (1976) J. Am. Chem. Soc. , vol.98 , pp. 2990-2996
    • Momany, F.A.1
  • 44
    • 0017128444 scopus 로고
    • Conformational energy analysis of the molecule, luteinizing hormone-releasing hormone. 2. Tetrapeptide and decapeptide analogues
    • Momany, F.A. (1976b) Conformational energy analysis of the molecule, luteinizing hormone-releasing hormone. 2. Tetrapeptide and decapeptide analogues. J. Am. Chem. Soc., 98, 2996-3000.
    • (1976) J. Am. Chem. Soc. , vol.98 , pp. 2996-3000
    • Momany, F.A.1
  • 45
    • 0015811931 scopus 로고
    • Synthetic analogues of the hypothalamic luteinizing hormone releasing factor with increased agonist or antagonist properties
    • Monahan, M., Amoss, M., Anderson, H. and Vale, W. (1973) Synthetic analogues of the hypothalamic luteinizing hormone releasing factor with increased agonist or antagonist properties. Biochemistry, 12, 4616-4620.
    • (1973) Biochemistry , vol.12 , pp. 4616-4620
    • Monahan, M.1    Amoss, M.2    Anderson, H.3    Vale, W.4
  • 46
    • 0027184025 scopus 로고
    • Conformation-function relationships in LHRH analogs. I. Conformation of LHRH peptide backbone
    • Nikiforovich, G.V. and Marshall, G.R. (1993a) Conformation-function relationships in LHRH analogs. I. Conformation of LHRH peptide backbone. Int. J. Pept. Protein Res., 42, 171-180.
    • (1993) Int. J. Pept. Protein Res. , vol.42 , pp. 171-180
    • Nikiforovich, G.V.1    Marshall, G.R.2
  • 47
    • 0027184026 scopus 로고
    • Conformation-function relationships in LHRH analogs. II. Conformations of LHRH peptide agonists and antagonists
    • Nikiforovich, G.V. and Marshall, G.R. (1993b) Conformation-function relationships in LHRH analogs. II. Conformations of LHRH peptide agonists and antagonists. Int. J. Pept. Protein Res., 42, 181-193.
    • (1993) Int. J. Pept. Protein Res. , vol.42 , pp. 181-193
    • Nikiforovich, G.V.1    Marshall, G.R.2
  • 48
    • 13144283014 scopus 로고
    • Clinical pharmacology of LHRH antagonists
    • Vickery, B.H. and Lunenfeld, B. (eds), Kluwer Academic Publishers, Dordrecht
    • Pavlou, S.N., Rivier, J., Vale, W. and Kamilaris, T. (1990a) Clinical pharmacology of LHRH antagonists. In Vickery, B.H. and Lunenfeld, B. (eds), Precocious Puberty, Contraception and Safety Issues. Kluwer Academic Publishers, Dordrecht, pp. 127-131.
    • (1990) Precocious Puberty, Contraception and Safety Issues , pp. 127-131
    • Pavlou, S.N.1    Rivier, J.2    Vale, W.3    Kamilaris, T.4
  • 49
    • 0025269960 scopus 로고
    • Persistence of concordant luteinizing hormone (LH), testosterone and a-subunit pulses following LH-releasing hormone antagonists administration in normal men
    • Pavlou, S.N., Veldhuis, J., Lindner, J. et al. (1990b) Persistence of concordant luteinizing hormone (LH), testosterone and a-subunit pulses following LH-releasing hormone antagonists administration in normal men. J. Clin. Endocrinol. Metab., 70, 1472-1478.
    • (1990) J. Clin. Endocrinol. Metab. , vol.70 , pp. 1472-1478
    • Pavlou, S.N.1    Veldhuis, J.2    Lindner, J.3
  • 50
    • 0027241297 scopus 로고
    • An a-aminoglycine derivative suitable for solid phase peptide synthesis using Fmoc strategy
    • Qasmi, D., Rene, L. and Badet, B. (1993) An a-aminoglycine derivative suitable for solid phase peptide synthesis using Fmoc strategy. Tetrahedron Lett., 34, 3861-3862.
    • (1993) Tetrahedron Lett. , vol.34 , pp. 3861-3862
    • Qasmi, D.1    Rene, L.2    Badet, B.3
  • 51
    • 0002995352 scopus 로고
    • Novel antagonists of GnRH: A compendium of their physicochemical properties. activities, relative potencies and efficacy in humans
    • Lunenfeld, B. and Insler, V. (eds), Parthenon Publishing Group. Carnforth, UK
    • Rivier, J. (1993) Novel antagonists of GnRH: a compendium of their physicochemical properties. activities, relative potencies and efficacy in humans. In Lunenfeld, B. and Insler, V. (eds), GnRH Analogues. The State of the Art 1993. Parthenon Publishing Group. Carnforth, UK, pp. 13-26.
    • (1993) GnRH Analogues. The State of the Art 1993 , pp. 13-26
    • Rivier, J.1
  • 52
    • 0022472366 scopus 로고
    • New effective gonadotrophin releasing hormone antagonists with minimal potency for histamine release in vitro
    • Rivier, J., Porter, J., Rivier, C. et al. (1986) New effective gonadotrophin releasing hormone antagonists with minimal potency for histamine release in vitro. J. Med. Chem., 29, 1846-1851.
    • (1986) J. Med. Chem. , vol.29 , pp. 1846-1851
    • Rivier, J.1    Porter, J.2    Rivier, C.3
  • 54
    • 0023902148 scopus 로고
    • Design of potent cyclic gonadotrophin releasing hormone (GnRH) antagonists
    • Rivier, J., Kupryszewski, G., Varga, J. et al. (1988b) Design of potent cyclic gonadotrophin releasing hormone (GnRH) antagonists. J. Med. Chem., 31, 677-682.
    • (1988) J. Med. Chem. , vol.31 , pp. 677-682
    • Rivier, J.1    Kupryszewski, G.2    Varga, J.3
  • 55
    • 0342465680 scopus 로고
    • Design, computer derived structure and biological activity of three bicyclic gonadotrophin releasing hormone (GnRH) antagonists
    • Villafranca, J. (ed.). Academic Press, Seattle
    • Rivier, J., Koerber, S., Rivier, C. et al. (1990) Design, computer derived structure and biological activity of three bicyclic gonadotrophin releasing hormone (GnRH) antagonists. In Villafranca, J. (ed.). Current Research in Protein Chemistry, Academic Press, Seattle, pp. 273-281.
    • (1990) Current Research in Protein Chemistry , pp. 273-281
    • Rivier, J.1    Koerber, S.2    Rivier, C.3
  • 58
    • 0026457816 scopus 로고
    • Gonadotropin releasing hormone antagonists with Nω-triazolyl-ornithine, -lysine or -para-aminophenylalanine residues at positions 5 and 6
    • Rivier, J., Porter, J., Hoeger, C. et al. (1992) Gonadotropin releasing hormone antagonists with Nω-triazolyl-ornithine, -lysine or -para-aminophenylalanine residues at positions 5 and 6. J. Med. Chem., 35, 4270-4278.
    • (1992) J. Med. Chem. , vol.35 , pp. 4270-4278
    • Rivier, J.1    Porter, J.2    Hoeger, C.3
  • 59
    • 0029067091 scopus 로고
    • GnRH antagonists: Novel members of the azaline B family
    • Rivier, J.E., Jiang, G., Porter, J. et al. (1995) GnRH antagonists: novel members of the azaline B family. J. Med. Chem., 38, 2649-2662.
    • (1995) J. Med. Chem. , vol.38 , pp. 2649-2662
    • Rivier, J.E.1    Jiang, G.2    Porter, J.3
  • 61
    • 0029882807 scopus 로고    scopus 로고
    • Betidamino acids: Versatile and constrained scaffolds for drug discovery
    • Rivier, J.E., Jiang, G.-C., Koerber, S.C. et al. (1996b) Betidamino acids: versatile and constrained scaffolds for drug discovery. Proc. Natl. Acad. Sci. USA, 96, 2031-2036.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2031-2036
    • Rivier, J.E.1    Jiang, G.-C.2    Koerber, S.C.3
  • 62
    • 0026644295 scopus 로고
    • Conformational analysis of a highly potent, constrained gonadotropin-releasing hormone antagonist. 2. Molecular dynamics simulations
    • Rizo, J., Koerber, S.C., Bienstock, R.J. et al. (1992a) Conformational analysis of a highly potent, constrained gonadotropin-releasing hormone antagonist. 2. Molecular dynamics simulations. J. Am. Chem. Soc., 114, 2860-2871.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 2860-2871
    • Rizo, J.1    Koerber, S.C.2    Bienstock, R.J.3
  • 63
    • 0026756614 scopus 로고
    • Conformational analysis of a highly potent, constrained gonadotropin-releasing hormone antagonist. 1. Nuclear magnetic resonance
    • Rizo, J., Koerber, S.C., Bienstock, R.J. et al. (1992b) Conformational analysis of a highly potent, constrained gonadotropin-releasing hormone antagonist. 1. Nuclear magnetic resonance. J. Am. Chem. Soc., 114, 2852-2859.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 2852-2859
    • Rizo, J.1    Koerber, S.C.2    Bienstock, R.J.3
  • 64
    • 0025610482 scopus 로고
    • Accelerated dissolution of luteal-endometrial integrity by the administration of antagonists of GnRH and prosterone to late luteal phase women
    • Roseff, S.J., Kettel, L.M., Rivier, J. et al. (1990) Accelerated dissolution of luteal-endometrial integrity by the administration of antagonists of GnRH and prosterone to late luteal phase women. Fertil. Steril., 54, 805-810.
    • (1990) Fertil. Steril. , vol.54 , pp. 805-810
    • Roseff, S.J.1    Kettel, L.M.2    Rivier, J.3
  • 65
    • 0025891905 scopus 로고
    • The induction of premature luteolysis in normal women-follicular LH secretion and corpus luteum function in the subsequent cycle
    • Soules, M.R., Bremner, W.J., Dahl, K.D. et al. (1990) The induction of premature luteolysis in normal women-follicular LH secretion and corpus luteum function in the subsequent cycle. Am. J. Obstet. Gynecol., 164, 989-996.
    • (1990) Am. J. Obstet. Gynecol. , vol.164 , pp. 989-996
    • Soules, M.R.1    Bremner, W.J.2    Dahl, K.D.3
  • 66
    • 0018376648 scopus 로고
    • On the conformation of luteinizing hormone-releasing hormone, nuclear overhauser observations
    • Sprecher, R.F. and Momany, F.A. (1979) On the conformation of luteinizing hormone-releasing hormone, nuclear overhauser observations. Biochem. Biophys. Res. Commun., 87, 72-77.
    • (1979) Biochem. Biophys. Res. Commun. , vol.87 , pp. 72-77
    • Sprecher, R.F.1    Momany, F.A.2
  • 67
    • 0025050722 scopus 로고
    • Hormonal responses to a potent gonadotrophin hormone-releasing antagonist in normal elderly men
    • Tenover, J.S., Dahl, K.D., Vale, W.W. et al. (1990) Hormonal responses to a potent gonadotrophin hormone-releasing antagonist in normal elderly men. J. Clin. Endocrinol. Metab., 71, 881-888.
    • (1990) J. Clin. Endocrinol. Metab. , vol.71 , pp. 881-888
    • Tenover, J.S.1    Dahl, K.D.2    Vale, W.W.3
  • 71
    • 0017122834 scopus 로고
    • The effects of isolated N-methylated residues on the Conformational characteristics of polypeptides
    • Tonelli, A.E. (1976) The effects of isolated N-methylated residues on the Conformational characteristics of polypeptides. Biopolymers, 15, 1615-1622.
    • (1976) Biopolymers , vol.15 , pp. 1615-1622
    • Tonelli, A.E.1
  • 72
    • 0025367725 scopus 로고
    • Suppressive actions of a gonadotropin-releasing hormone (GnRH) antagonist on LH, FSH, and prolactin release in estrogen-deficient postmenopausal women
    • Urban, R.J., Pavlou, S.N., Rivier, J.E. et al. (1990) Suppressive actions of a gonadotropin-releasing hormone (GnRH) antagonist on LH, FSH, and prolactin release in estrogen-deficient postmenopausal women. Am. J. Obstet. Gynecol., 162, 1255-1260.
    • (1990) Am. J. Obstet. Gynecol. , vol.162 , pp. 1255-1260
    • Urban, R.J.1    Pavlou, S.N.2    Rivier, J.E.3
  • 73
    • 0010240184 scopus 로고
    • High resolution nuclear magnetic resonance studies of the conformation of the luteinizing hormone-releasing hormone (LH-RH) and its component peptides
    • Wessels, P.L., Feeney, J., Gergory, H. and Gormley, J.J. (1973) High resolution nuclear magnetic resonance studies of the conformation of the luteinizing hormone-releasing hormone (LH-RH) and its component peptides. J.C.S. Perkin, II, 1691-1698.
    • (1973) J.C.S. Perkin , vol.2 , pp. 1691-1698
    • Wessels, P.L.1    Feeney, J.2    Gergory, H.3    Gormley, J.J.4


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