Effect of antiviral treatment on the shedding of HIV-1 in semen

AIDS

Volumn 11, Issue 10, 1997, Pages 1249-1254

  Vernazza, Pietro L ^a,d   Gilliam, Bruce L ^b   Flepp, Markus ^c   Dyer, John R ^b   Frank, Andreas C ^a   Fiscus, Susan A ^b   Cohen, Myron S ^b   Eron, Joseph J ^b  

^a Inst Clin Microbiol and Immunol   (Switzerland)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d Institute for Clinical Microbiology   (Switzerland)

Author keywords

Antiviral treatment; HIV RNA; Semen; Sexual transmission; Viral load

Indexed keywords

ANTIRETROVIRUS AGENT; VIRUS RNA;

ARTICLE; BLOOD SAMPLING; CELL CULTURE; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; DRUG EFFICACY; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; PRIORITY JOURNAL; RNA ANALYSIS; SEMEN ANALYSIS; SEMINAL PLASMA; VIRUS SHEDDING; VIRUS TITRATION;

ANTI-HIV AGENTS; HIV INFECTIONS; HIV-1; HUMANS; MALE; RNA, VIRAL; SEMEN; STATISTICS, NONPARAMETRIC; VIRUS CULTIVATION;

EID: 0030791369     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199710000-00008     Document Type: Article

References (30)

1. Carpenter CCJ, Fischl MA, Hammer SM, et al.: Antiretroviral therapy for HIV infection in 1996: recommendations of an international panel. JAMA 1996, 276:146-154.
2. Anderson RM, Gupta S, May RM: Potential of community-wide chemotherapy or immunotherapy to control the spread of HIV-1. Nature 1991, 350: 356-359.
3. Royce RA, Seny A, Cates W, Cohen MS: Sexual transmission of HIV: host factors that shape the epidemic and implications for prevention. N Engl J Med 1997, 336:1072-1078.
4. Mussico M, Lazzarin A, Nicolosi A, et al.: Antiretroviral treatment of men infected with human immunodeficiency virus type 1 reduces the incidence of heterosexual transmission. Arch Intern Med 1994, 154:1971-1976.
5. Gilliam BL, Dyer J, Fiscus SA, et al.: Effects of reverse transcriptase inhibitor therapy on HIV-1 viral burden in semen. J Acquir Immune Defic Syndr Hum Retrovirol 1997, 15:54-60.
6. Wathen LK, Nuorala KW, Patel RK, et al.: Validation of a quantitative DNA PCR assay for HIV-1 in human peripheral blood mononuclear cells. XI International Conference on AIDS. Vancouver, July 1996 [abstract 520].
7. Vernazza PL, Gilliam BL, Dyer JR, et al.: Quantification of HIV in semen: correlation with antiviral treatment and immune status. AIDS 1997, 11:989-995.
8. Dyer JR, Gilliam BL, Eron JJ, Grosso L, Cohen MS, Fiscus SA: Quantitation of human immunodeficiency virus type 1 RNA in cell free seminal plasma: comparison of NASBA (TM) with Amplicor reverse transcription-PCR amplification and correlation with quantitative culture. J Virol Meth 1996, 60:161-170.
9. van Gemen B, van Beuningen R, Nabbe A, et al.: A one-tube quantitative HIV-1 RNA NASBA nucleic acid amplification assay using electrochemiluminescent (ECL) labelled probes. J Virol Meth 1994, 49:157-167.
10. O'Brien WA, Hartigan PM, Martin D, et al.: Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS. N Engl J Med 1996, 334:426-431.
11. Katzenstein TL, Pedersen C, Nielsen C, Lundgren JD, Jakobsen PH, Gerstoft J: Longitudinal serum HIV RNA quantification: correlation to viral phenotype at seroconversion and clinical outcome. AIDS 1996, 10:167-173.
12. Anderson DJ, O'Brien TR, Politch JA, et al.: Effects of disease stage and zidovudine therapy on the detection of human immunodeficiency virus type-1 in semen. JAMA 1992, 267:2769-2774.
13. Hamed KA, Winters MA, Holodniy M, Katzenstein DA, Merigan TC: Detection of human immunodeficiency virus type 1 in semen: effects of disease stage and nucleoside therapy. J Infect Dis 1993, 167:798-802.
14. O'Brien TR, Anderson DJ, Seage GR: Inverse association between zidovudine (AZT) therapy and the prevalence of HIV in semen. VII International Conference on AIDS, Florence, Italy, 1991 [abstract 3092].
15. Seage G, Mayer K, Horsburgh C, et al.: Prospective evaluation of effect of zidovudine on detection of HIV-1 in semen. IX International Conference on AIDS, Berlin, Germany, 1993 [abstract 3291].
16. Anderson RM: The transmission dynamics of sexually transmitted diseases: the behavioural component. In Infectious Diseases of Humans: Dynamics and Control. Edited by Anderson RM, May RM. Oxford: Oxford University Press, 1991.
17. Vernazza PL, Eron JJ, Cohen MS, Vanderhorst CM, Troiani L, Fiscus SA: Detection and biologic characterization of infectious HIV- 1 in semen of seropositive men. AIDS 1994, 8:1325-1329.
18. Speck C, Coombs R, Koutsky L, et al.: Rates and determinants of HIV-1 shedding in semen. XI International Conference on AIDS. Vancouver, Canada, 1996 [abstract 334].
19. Goedert JJ, Eyster ME, Biggar RJ, Blattner WA: Heterosexual transmission of human immunodeficiency virus: association with severe depletion of T-helper lymphocytes in men with hemophilia. AIDS Res Hum Retrovirus 1987, 3:355-361.
20. Seage GR, Horsburgh Jr CR, Hardy AM, et al.: Increased suppressor T cells in probable transmitters of human immunodeficiency virus infection. Am J Public Health 1989, 79:1638-1642.
21. Seage GR, Mayer KH, Horsburgh Jr CR: Risk of human immunodeficiency virus infection from unprotected receptive anal intercourse increases with decline in immunologic status of infected partners. Am J Epidemiol 1993, 137:899-908.
22. Devincenzi I: Longitudinal study of human immunodeficiency virus transmission by heterosexual partners. N Engl J Med 1994, 331:341-346.
23. Cohen MS, Hoffman IF, Royce RA, et al.: Treatment of urethritis reduces the concentration of HIV-1 in semen: implications for prevention of transmission of HIV-1. Lancet 1997 (in press).
24. Grosskurth H, Mosha P, Todd J, et al.: Impact of improved treatment of sexually transmitted diseases on HIV infection in rural Tanzania: randomised controlled trial. Lancet 1993, 346:530-536.
25. Pearcepratt R, Phillips DM: Studies of adhesion of lymphocytic cells: implications for sexual transmission of human immunodeficiency virus. Biol Reprod 1993, 48:431-435.
26. Busch MP, Operskalski EA, Mosley JW, et al.: Factors influencing human immunodeficiency virus type 1 transmission by blood transfusion. J Infect Dis 1996, 174:26-33.
27. Fang GW, Burger H, Grimson R, et al.: Maternal plasma human immunodeficiency virus type 1 RNA level: a determinant and projected threshold for mother-to-child transmission. Proc Natl Acad Sci USA 1995, 92:12100-12104.
28. Sperling RS, Shapiro DE, Coombs RW, et al.: Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. N Engl J Med 1996, 335:1621-1629.
29. Lee IH, Sakahara N, Fiebig E, Busch MP, O Brien TR, Herman SA: Correlation of HIV-1 RNA levels in plasma and heterosexual transmission of HIV-1 from infected transfusion recipients. J Acquir Immune Defic Syndr Hum Retrovirol 1996, 12:427-428.
30. Erice A, Mayers DL, Strike DG, et al.: Primary infection with zidovudine-resistant human immunodeficiency virus type 1. N Engl J Med 1993, 328:1163-1165.