Targeting a recombinant adenovirus vector to HCC cells using a bifunctional Fab-antibody conjugate

Biochemical and Biophysical Research Communications

Volumn 272, Issue 2, 2000, Pages 497-504

  Yoon, Seung Kew ^a,c   Mohr, Leonhard ^a,d   O'Riordan, Catherine R ^b   Lachapelle, Amy ^b   Armentano, Donna ^b   Wands, Jack R ^a  

^a MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^b GENZYME CORPORATION   (United States)

^c The Catholic University of Korea   (South Korea)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Adenovirus; Human hepatocellular carcinoma; Monoclonal antibody; Targeting

Indexed keywords

ANTIBODY CONJUGATE; BETA GALACTOSIDASE; MONOCLONAL ANTIBODY; VIRUS VECTOR;

ADENOVIRUS; ARTICLE; CARCINOMA CELL; COMPETITIVE INHIBITION; CONTROLLED STUDY; CROSS LINKING; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; PRIORITY JOURNAL; REPORTER GENE;

ADENOVIRIDAE;

EID: 0034616659     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.2788     Document Type: Article

References (25)

1. Wands J. R., Blum H. E. Primary hepatocellular carcinoma. N. Engl. J. Med. 325:1991;729-731.
2. Anderson W. F. Human gene therapy. Nature. 391:1998;25-30.
3. Bergelson J. M., Cunningham J. A., Droguett G., Kurt-Jones E. A., Krithivas A., Hong J. S., Horwitz M. S., Crowell R. L., Finberg R. W. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science. 275:1997;1320-1323.
4. Goldman M. J., Wilson J. M. Expression of alpha v beta 5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway. J. Virol. 69:1995;5951-5958.
5. Bao J. J., Zhang W. W., Kuo M. T. Adenoviral delivery of recombinant DNA into transgenic mice bearing hepatocellular carcinomas. Hum. Gene Ther. 7:1996;355-365.
6. Qian C., Idoate M., Bilbao R., Sangro B., Bruna O., Vazquez J., Prieto J. Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma. Hum. Gene Ther. 8:1997;349-358.
7. Wilson B., Ozturk M., Takahashi H., Motte P., Kew M., Isselbacher K. J., Wands J. R. Cell-surface changes associated with transformation of human hepatocytes to the malignant phenotype. Proc. Natl. Acad. Sci. USA. 85:1988;3140-3144.
8. Moradpour D., Compagnon B., Wilson B. E., Nicolau C., Wands J. R. Specific targeting of human hepatocellular carcinoma cells by immunoliposomes in vitro. Hepatology. 22:1995;1527-1537.
9. Compagnon B., Moradpour D., Alford D. Enhanced gene delivery and expression in human hepatocellular carcinoma cells by cationic immunoliposomes. J. Liposome Res. 7:1997;127-141.
10. Takahashi H., Ozturk M., Wilson B., Maki A., Ozawa K., Koizumi M., Endo K., Strauss W., Shouval D., Wands J. In vivo expression of two novel tumor-associated antigens and their use in immunolocalization of human hepatocellular carcinoma. Hepatology. 9:1989;625-634.
11. Mohr L., Schauer J. I., Boutin R. H., Moradpour D., Wands J. R. Targeted gene transfer to hepatocellular carcinoma cells using a novel monoclonal antibody-based gene delivery system. Hepatology. 29:1999;82-89.
12. Armentano D., Zabner J., Sacks C., Sookdeo C. C., Smith M. P., St. George J. A., Wadsworth S. C., Smith A. E., Gregory R. J. Effect of the E4 region on the persistence of transgene expression from adenovirus vectors. J. Virol. 71:1997;2408-2416.
13. Bruix J. Treatment of hepatocellular carcinoma. Hepatology. 25:1997;259-262.
14. Qian C., Bilbao R., Bruna O., Prieto J. Induction of sensitivity to ganciclovir in human hepatocellular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase. Hepatology. 22:1995;118-123.
15. Kaneko S., Hallenbeck P., Kotani T., Nakabayashi H., McGarrity G., Tamaoki T., Anderson W. F., Chiang Y. L. Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression. Cancer Res. 55:1995;5283-5287.
16. Kanai F., Lan K. H., Shiratori Y., Tanaka T., Ohashi M., Okudaira T., Yoshida Y., Wakimoto H., Hamada H., Nakabayashi H., Tamaoki T., Omata M. In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene. Cancer Res. 57:1997;461-465.
17. Bui L. A., Butterfield L. H., Kim J. Y., Ribas A., Seu P., Lau R., Glaspy J. A., McBride W. H., Economou J. S. In vivo therapy of hepatocellular carcinoma with a tumor-specific adenoviral vector expressing interleukin-2. Hum. Gene Ther. 8:1997;2173-2182.
18. Huang H., Chen S. H., Kosai K., Finegold M. J., Woo S. L. Gene therapy for hepatocellular carcinoma: Long-term remission of primary and metastatic tumors in mice by interleukin-2 gene therapy in vivo. Gene Ther. 3:1996;980-987.
19. Richards C. A., Austin E. A., Huber B. E. Transcriptional regulatory sequences of carcinoembryonic antigen: Identification and use with cytosine deaminase for tumor-specific gene therapy. Hum. Gene Ther. 6:1995;881-893.
20. Kanai F., Shiratori Y., Yoshida Y., Wakimoto H., Hamada H., Kanegae Y., Saito I., Nakabayashi H., Tamaoki T., Tanaka T., Lan K. H., Kato N., Shiina S., Omata M. Gene therapy for alpha-fetoprotein-producing human hepatoma cells by adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene. Hepatology. 23:1996;1359-1368.
21. Cotten M., Langle-Rouault F., Kirlappos H., Wagner E., Mechtler K., Zenke M., Beug H., Birnstiel M. L. Transferrin-polycation-mediated introduction of DNA into human leukemic cells: Stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels. Proc. Natl. Acad. Sci. USA. 87:1990;4033-4037.
22. Chen J., Gamou S., Takayanagi A., Shimizu N. A novel gene delivery system using EGF receptor-mediated endocytosis. FEBS Lett. 338:1994;167-169.
23. Nassander U. K., Steerenberg P. A., Poppe H., Storm G., Poels L. G., De Jong W. H., Crommelin D. J. In vivo targeting of OV-TL 3 immunoliposomes to ascitic ovarian carcinoma cells (OVCAR-3) in athymic nude mice. Cancer Res. 52:1992;646-653.
24. Ahmad I., Longenecker M., Samuel J., Allen T. M. Antibody-targeted delivery of doxorubicin entrapped in sterically stabilized liposomes can eradicate lung cancer in mice. Cancer Res. 53:1993;1484-1488.
25. Douglas J. T., Rogers B. E., Rosenfeld M. E., Michael S. I., Feng M., Curiel D. T. Targeted gene delivery by tropism-modified adenoviral vectors. Nat. Biotechnol. 14:1996;1574-1578.