Helper T-cell epitope immunodominance associated with structurally stable segments of hen egg lysozyme and HIV gp120

Journal of Theoretical Biology

Volumn 203, Issue 3, 2000, Pages 189-201

  Landry, Samuel J ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLYCOPROTEIN GP 120; LYSOZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE ANTIGEN;

ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; GENETIC CONSERVATION; HELPER CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0034615793     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.1999.1056     Document Type: Article

References (63)

1. Protein folding intermediates: Native-state hydrogen exchange
2. Major histocompatibility complex class II-associated invariant chain fragment is a strong inhibitor of lysosomal cathepsin L
3. Analysis of peptide binding patterns in different major histocompatibility complex/T cell receptor complexes using pigeon cytochrome c-specific T cell hybridomas. Evidence that a single peptide binds major histocompatibility complex in different conformations
4. The specificity of bovine spleen cathepsin S. A comparison with rat liver cathepsins L and B
5. 3-Dimensional structure of the human class-II histocompatibility antigen HLA-DR1
6. Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size
7. An interactive web site providing major histocompatibility ligand predictions: Applications to HIV research
8. T-cell antigenic sites tend to be amiphipathic structures
9. Interaction of the pertussis toxin peptide containing residues 30-42 with DR1 and the T-cell receptors of 12 human T-cell clones
10. Binding to Ia protects an immunogenic peptide from proteolytic degradation
11. Initiation of autoimmunity to the p53 tumor suppressor protein by complexes of p53 and SV40 large T antigen
12. Pool-sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules
13. Proteolysis of major histocompatibility complex class II-associated invariant chain is regulated by the alternatively spliced gene product, p41
14. In vitro processing of proopiomelanocortin by recombinant PC1 (SPC3)
15. T cell determinant structures: Cores and determinant envelopes in three mouse major histocompatibility complex haplotypes
16. T cell multideterminant regions in the human immunodeficiency virus envelope: Toward overcoming the problem of major histocompatibility complex restriction
17. High-affinity binding of short peptides to major histocompatibility complex class II molecules by anchor combinations
18. Conformational and structural characteristics of peptides binding to HLA-DR molecules
19. Isolation and characterization of independently folding regions of the beta chain of Escherichia coli tryptophan synthase
20. Molecular recognition. Conformational analysis of limited proteolytic sites and serine proteinase protein inhibitors
21. Modeling studies of the change in conformation required for cleavage of limited proteolytic sites
22. Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-A(d)
23. Crystallographic analysis of endogenous peptides associated with HLA-DR1 suggests a common, polyproline II-like conformation for bound peptides
24. Processing of the precursors to neurotensin and other bioactive peptides by cathepsin E
25. Backbone dynamics of proteins as studied by 15-N inverse detected heteronuclear NMR spectroscopy: Application to staphylococcal nuclease
26. Self and foreign peptides interact with intact and disassembled MHC class-II antigen HLA-DR via tryptophan pockets
27. Editing of the HLA-DR-peptide repertoire by HLA-DM
28. Crystal structure of hen egg-white lysozyme at a hydrostatic pressure of 1000 atmospheres
29. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
30. Local protein instability predictive of helper T-cell epitopes
31. HIV-1 env DNA vaccine administered to rhesus monkeys elicits MHC class II-restricted CD4+ T helper cells that secrete IFN-gamma and TNF-alpha
32. Action of human liver cathepsin B on the oxidized insulin B chain
33. Constraints in T-B co-operation related to epitope topology on E. coli β-galactosidase I. The fine specificity of antibodies directed to conformation-dependent determinants
34. Differential activation of T cell clones stimulated by macrophages exposed to antigen complexed with monoclonal antibodies
35. Antigen processing and T cell repertoires as crucial aleatory features in induction of autoimmunity
36. MHC molecules protect T cell epitopes against proteolytic destruction
37. Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell
38. Correlation among sites of limited proteolysis, enzyme accessibility and segmental mobility
39. 95- and 25-kDa fragments of the human immunodeficiency virus envelope glycoprotein gp120 bind to the CD4 receptor
40. Hydrogen exchange in native and denatured states of hen egg-white lysozyme
41. Study of protein dynamics by X-ray diffraction
42. A sequence pattern common to T cell epitopes
43. Structural model of HLA-DR1 restricted T cell antigen recognition
44. Sequence analysis of peptides bound to MHC Class-II molecules
45. T cell recognition of HIV synthetic peptides in a natural infection
46. Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants
47. Induction of homologous virus neutralizing antibodies in guinea pigs immunized with two human immunodeficiency virus type 1 glycoprotein gp120-iscom preparations
48. A chink in HIV's armour?
49. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
50. The structure of T cell epitopes
51. Identification of proteases that process distinct epitopes on the same protein
52. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
53. Selective cleavage of peptide bonds by cathepsins L and B from rat liver
54. Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors
55. Selective release of some invariant chain-derived peptides from HLA-DR1 molecules at endosomal pH
56. In a vaccine model, selected substitution of a highly stimulatory T cell epitope of hen's egg lysozyme into a Salmonella flagellin does not result in a homologous, specific, cellular immune response and may alter the way in which the total antigen is processed
57. Reactivation of 3-phosphoglycerate kinase from its unfolded proteolytic fragments
58. The generation of immunogenic peptides can be selectively increased or decreased by proteolytic enzyme inhibitors
59. Identification of a major I-Ek-restricted determinant of hen egg lysozyme: Limitations of lymph node proliferation studies in defining immunodominance and crypticity
60. HIV-1 peptides induce a proliferative response in lymphocytes from infected persons
61. Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
62. Structural organization of the multifunctional animal fatty-acid synthase