In a vaccine model, selected substitution of a highly stimulatory T cell epitope of hen's egg lysozyme into a Salmonella flagellin does not result in a homologous, specific, cellular immune response and may alter the way in which the total antigen is processed

Vaccine

Volumn 15, Issue 3, 1997, Pages 321-324

  Vanegas, Ricardo A ^a   Street, Nancy E ^b   Joys, Terence M ^a,b  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

cell mediated immune response; Salmonella; T cell epitope

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL VACCINE; EPITOPE; FLAGELLIN; LYSOZYME;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DNA SEQUENCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA; T LYMPHOCYTE ACTIVATION; VACCINATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGEN PRESENTATION; EPITOPES; FLAGELLIN; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MURAMIDASE; SALMONELLA; T-LYMPHOCYTES; TYPHOID-PARATYPHOID VACCINES; VACCINES, SYNTHETIC;

EID: 0031043273     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(96)00167-3     Document Type: Article

References (15)

1. DePamphilis, M.L. and Adler, J. Purification of intact flagella from Escherichi coli and Bacillus subtilis. J. Bacteriol. 1971, 105, 376
2. Astbury, W.T., Beighton, E. and Weibull, C. The structure of bacterial flagella. Symp. Soc. Exp. Biol. 1955, 9, 282
3. Iino, T., Komeda, Y., Kutsukake, K. et al. New unified nomenclature for the flagellar genes of Escherichi coli and Salmonella typhimurium. Microbiol. Rev. 1988, 52, 15758
4. Joys, T.M. The flagellar filament protein. Can. J. Microbiol. 1988, 34, 452
5. Joys, T.M. and Schödel, F. Epitope mapping of the d flagellar antigen of Salmonella muenchen. Infect. Immun. 1991, 59, 3330
6. Edwards, P.R. and Ewing, W.H. Identification of Enterobacteriaceae, 4th Edn. Burgess Publishing Company, Minneapolis, MN, 1986
7. Newton, S.M.C., Jacob, C.O. and Stocker, B.A.D. Immune response to cholera toxin epitope inserted in Salmonella flagella. Science 1989, 244, 70
8. d encodes a dominant surface epitope and a stabilizing factor for functional flagella. J. Bacteriol. 1994, 176, 2406
9. Verma, N.K., Ziegler, H.K., Wilson, M. et al. Delivery of class I and class II MHC-restricted T cell epitopes of listeriolysin of Listeria monocytogenes by attenuated Salmonella. Vaccine 1995, 13, 142
10. Verma, N.K., Ziegler, H.K., Stocker, B.A.D. and Schoolnik, G.K. Induction of a cellular immune response to a defined T-cell epitope as an insert in the flagellin of a live vaccine strain of Salmonella. Vaccine 1995, 13, 235
11. Joys, T.M. and Street, N.E. Mapping of T cell epitopes of flagellar antigen d of Salmonella muenchen. Infect. Immun. 1994, 61, 1146
12. Gamon, G., Geysen, H.M., Apple, R.J. et al. T cell determinant structures: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes. J. Exp. Med. 1991, 173, 609
13. Higuchi, R. Recombinant PCR. In: P.C.R. Protocols (Eds Innis, M.A., Gelfand, D.H., Sninsky, J.J. and White, T.J.). Academic Press, New York, 1990
14. Maniatis, T., Fritsch, E.F. and Sambrook, J. Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1978
15. Elish, M.E., Pierce, J.R., Earhart, C.F., J. Gen. Microbiol. 1988, 134, 1355