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Volumn 24, Issue 3, 1999, Pages 269-277

Omapatrilat. Antihypertensive, treatment of heart failure, ACE inhibitor, neutral endopeptidase inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

7 (2 ACETYLTHIO 3 PHENYLPROPIONAMIDO) 1,2,3,4,6,7,8,12B OCTAHYDRO 6 OXOPYRIDO[2,1 A][2]BENZAZEPINE 4 CARBOXYLIC ACID; ANTIHYPERTENSIVE AGENT; BMS 182657; CGS 26582; DAGLUTRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENKEPHALINASE INHIBITOR; ER 32935; FASIDOTRIL; OMAPATRILAT; SA 6817; SAMPRATRILAT; SCH 54470; UNCLASSIFIED DRUG; Z 13752A;

EID: 0032938106     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1999.024.03.489142     Document Type: Review
Times cited : (11)

References (36)
  • 1
    • 17644438887 scopus 로고    scopus 로고
    • Dual metalloprotease inhibitors: Mercaptoacetyl-based fused heterocyclic dipep-tide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase
    • Robl, J.A., Sun, C.-Q., Stevenson, J. et al. Dual metalloprotease inhibitors: Mercaptoacetyl-based fused heterocyclic dipep-tide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase. J Med Chem 1997, 40: 1570-7.
    • (1997) J Med Chem , vol.40 , pp. 1570-1577
    • Robl, J.A.1    Sun, C.-Q.2    Stevenson, J.3
  • 3
    • 85069143845 scopus 로고    scopus 로고
    • Spotlight on double and triple enzyme inhibitors for treating cardiovascular disease
    • Spotlight on double and triple enzyme inhibitors for treating cardiovascular disease. Prous Science Daily Essentials Feb 24, 1999.
    • (1999) Prous Science Daily Essentials Feb 24
  • 4
    • 85069139791 scopus 로고    scopus 로고
    • Broad spectrum antihypertensive effects of dual metalloprotease inhibition
    • Trippodo, N.C., Robl, J.A., Asaad, M.M., Schaeffer, T.R., Cheung, H.S. Broad spectrum antihypertensive effects of dual metalloprotease inhibition. Am J Hypertens 1997, 10(4, Part 2): 99A.
    • (1997) Am J Hypertens , vol.10 , Issue.4 PART 2
    • Trippodo, N.C.1    Robl, J.A.2    Asaad, M.M.3    Schaeffer, T.R.4    Cheung, H.S.5
  • 6
    • 0000877531 scopus 로고    scopus 로고
    • Simultaneous inhibition of neutral endopeptidase and angiotensin converting enzyme by omapatrilat increased survival in heart failure hamsters greater than ACE inhibition
    • Abst 4095
    • Trippodo, N.C., Fox, M., Monticello, T.M., Panchal, B.C., Asaad, M.M. Simultaneous inhibition of neutral endopeptidase and angiotensin converting enzyme by omapatrilat increased survival in heart failure hamsters greater than ACE inhibition. Circulation 1998, 98(17, Suppl.): Abst 4095.
    • (1998) Circulation , vol.98 , Issue.17 SUPPL.
    • Trippodo, N.C.1    Fox, M.2    Monticello, T.M.3    Panchal, B.C.4    Asaad, M.M.5
  • 8
    • 0030812971 scopus 로고    scopus 로고
    • Quantitative determination of BMS-186716, a thiol compound, in rat plasma by high-performance liquid chromatography positive ion electrospray mass spectrometry after hydrolysis of the methyl acrylate adduct by the native esterases
    • Jemal, M., Hawthrone, D.J. Quantitative determination of BMS-186716, a thiol compound, in rat plasma by high-performance liquid chromatography positive ion electrospray mass spectrometry after hydrolysis of the methyl acrylate adduct by the native esterases. J Chromatogr B 1997, 698: 123-32.
    • (1997) J Chromatogr B , vol.698 , pp. 123-132
    • Jemal, M.1    Hawthrone, D.J.2
  • 9
    • 0030982280 scopus 로고    scopus 로고
    • Quantitative determination of BMS-186716, a thiol compound, in dog plasma by high-performance liquid chromatography-positive ion electrospray mass spectrometry after formation of the methyl acrylate adduct
    • Jemal, M., Hawthorne, D.J. Quantitative determination of BMS-186716, a thiol compound, in dog plasma by high-performance liquid chromatography-positive ion electrospray mass spectrometry after formation of the methyl acrylate adduct. J Chromatogr B 1997, 693: 109-16.
    • (1997) J Chromatogr B , vol.693 , pp. 109-116
    • Jemal, M.1    Hawthorne, D.J.2
  • 10
    • 84990629708 scopus 로고
    • High performance liquid chromatography/ionspray mass spectrometry of N-ethylmaleimide and acrylic acid ester derivatives for bioanalysis of thiol compounds
    • Jemal, M., Hawthorne, D. High performance liquid chromatography/ionspray mass spectrometry of N-ethylmaleimide and acrylic acid ester derivatives for bioanalysis of thiol compounds. Rapid Commun Mass Spectrom 1994, 8: 854-7.
    • (1994) Rapid Commun Mass Spectrom , vol.8 , pp. 854-857
    • Jemal, M.1    Hawthorne, D.2
  • 11
    • 85069136014 scopus 로고    scopus 로고
    • Dual neutral endopeptidase (NEP)/angiotensin converting enzyme (ACE) inhibition is biologically different from ACE inhibition, at the same level of ACE inhibition
    • Abst P31.024
    • Massien, C., Azizi, M., Guyene, T.T., Ménard, J. Dual neutral endopeptidase (NEP)/angiotensin converting enzyme (ACE) inhibition is biologically different from ACE inhibition, at the same level of ACE inhibition. J Hypertens 1998, 16(Suppl. 2): Abst P31.024.
    • (1998) J Hypertens , vol.16 , Issue.SUPPL. 2
    • Massien, C.1    Azizi, M.2    Guyene, T.T.3    Ménard, J.4
  • 12
    • 4243251597 scopus 로고    scopus 로고
    • Neutral endopeptidase (NEP)/angiotensin converting enzyme (ACE) inhibition with omapatrilat (OMA): What is beyond ACE inhibition?
    • Abst 4150
    • Azizi, M., Massien, C., Vesterqvist, O., Gielsdorf, W., Liao, W.-C., Mangold, B., Menard, J. Neutral endopeptidase (NEP)/angiotensin converting enzyme (ACE) inhibition with omapatrilat (OMA): What is beyond ACE inhibition? Circulation 1998, 98(17, Suppl.): Abst 4150.
    • (1998) Circulation , vol.98 , Issue.17 SUPPL.
    • Azizi, M.1    Massien, C.2    Vesterqvist, O.3    Gielsdorf, W.4    Liao, W.-C.5    Mangold, B.6    Menard, J.7
  • 13
    • 0001643315 scopus 로고    scopus 로고
    • Effects of BMS-186716, a new dual metalloprotease inhibitor, on pharmacodynamic markers of neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE) activity in healthy men
    • Abst PIV-46
    • Vesterqvist, O., Liao, W., Manning, J.A., Uderman, H., Delaney, C., Beierle, F., Swanson, B.N. Effects of BMS-186716, a new dual metalloprotease inhibitor, on pharmacodynamic markers of neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE) activity in healthy men. Clin Pharmacol Ther 1997, 61(2): Abst PIV-46.
    • (1997) Clin Pharmacol Ther , vol.61 , Issue.2
    • Vesterqvist, O.1    Liao, W.2    Manning, J.A.3    Uderman, H.4    Delaney, C.5    Beierle, F.6    Swanson, B.N.7
  • 15
    • 0001043165 scopus 로고    scopus 로고
    • Omapatrilat, a novel cardiovascular agent, improves hemodynamics in patients with heart failure
    • Abst 533
    • Klapholz, M., Thomas, I., Eng, C., Iteld, B.J., Ponce, G.A., Niederman, A.L., Bilsker, M., Heywood, J.T. Omapatrilat, a novel cardiovascular agent, improves hemodynamics in patients with heart failure. Circulation 1998, 98(17, Suppl.): Abst 533.
    • (1998) Circulation , vol.98 , Issue.17 SUPPL.
    • Klapholz, M.1    Thomas, I.2    Eng, C.3    Iteld, B.J.4    Ponce, G.A.5    Niederman, A.L.6    Bilsker, M.7    Heywood, J.T.8
  • 16
    • 0008086101 scopus 로고    scopus 로고
    • The effects of omapatrilat, a combined inhibitor of neutral endopeptidase and angiotensin-converting enzyme, on arterial function in chronic heart failure
    • Abst 1993
    • McClean, D.R., Melton, I.C., Crozier, I.G., Garlick, A.H., Richards, A.M., Nicholls, M.G., Ikram, H. The effects of omapatrilat, a combined inhibitor of neutral endopeptidase and angiotensin-converting enzyme, on arterial function in chronic heart failure. Eur Heart J 1998, 19(Suppl.): Abst 1993.
    • (1998) Eur Heart J , vol.19 , Issue.SUPPL.
    • McClean, D.R.1    Melton, I.C.2    Crozier, I.G.3    Garlick, A.H.4    Richards, A.M.5    Nicholls, M.G.6    Ikram, H.7
  • 17
    • 0000806676 scopus 로고    scopus 로고
    • Cardiac, renal and endocrine effects of three month treatment of chronic heart failure with the vasopeptidase inhibitor, omapatrilat
    • McClean, D., Ikram, H., Melton, I., Crozier, I., Garlick, A., Richards, M., Nicholls, G., Hume, M. Cardiac, renal and endocrine effects of three month treatment of chronic heart failure with the vasopeptidase inhibitor, omapatrilat. J Am Coll Cardiol 1999, 33(2, Suppl. A): 185A.
    • (1999) J Am Coll Cardiol , vol.33 , Issue.2 SUPPL. A
    • McClean, D.1    Ikram, H.2    Melton, I.3    Crozier, I.4    Garlick, A.5    Richards, M.6    Nicholls, G.7    Hume, M.8
  • 18
    • 0001332158 scopus 로고    scopus 로고
    • Long-term beneficial hemodynamic and neurohormonal effects of vasopeptidase inhibition with omapatrilat in heart failure
    • Ikram, H., McClean, D.R., Mehta, S. et al. Long-term beneficial hemodynamic and neurohormonal effects of vasopeptidase inhibition with omapatrilat in heart failure. J Am Coll Cardiol 1999, 33(2, Suppl. A): 185A.
    • (1999) J Am Coll Cardiol , vol.33 , Issue.2 SUPPL. A
    • Ikram, H.1    McClean, D.R.2    Mehta, S.3
  • 19
    • 85069144265 scopus 로고    scopus 로고
    • In development: New medicines for heart disease and stroke
    • In development: New medicines for heart disease and stroke. America's Pharmaceutical Companies Feb 12,1999.
    • (1999) America's Pharmaceutical Companies Feb 12
  • 20
    • 85069136663 scopus 로고
    • The mixed neutral endopeptidase/ angiotensin converting enzyme inhibitor BMS-182657 produces beneficial hemodynamic effects in hamsters with heart failure
    • Trippodo, N.C. et al. The mixed neutral endopeptidase/ angiotensin converting enzyme inhibitor BMS-182657 produces beneficial hemodynamic effects in hamsters with heart failure. Hypertension 1994, 23: 407.
    • (1994) Hypertension , vol.23 , pp. 407
    • Trippodo, N.C.1
  • 21
    • 0028024053 scopus 로고
    • Dual metalloprotease inhibitors. I. Constrained peptidomimetics of mercaptoacyl dipeptides
    • Robl, J.A. et al. Dual metalloprotease inhibitors. I. Constrained peptidomimetics of mercaptoacyl dipeptides. Bioorg Med Chem Lett 1994, 4: 1789.
    • (1994) Bioorg Med Chem Lett , vol.4 , pp. 1789
    • Robl, J.A.1
  • 22
    • 0029619616 scopus 로고
    • Cardiovascular effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme BMS-182657 in experimental hypertension and heart failure
    • Trippodo, N.C., Robl, J.A., Asaad, M.M., Bird, J.E., Panchal, B.C., Schaeffer, T.R., Fox, M., Giancarli, M.R., Cheung, H.S. Cardiovascular effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme BMS-182657 in experimental hypertension and heart failure. J Pharmacol Exp Ther 1995, 275: 745-52.
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 745-752
    • Trippodo, N.C.1    Robl, J.A.2    Asaad, M.M.3    Bird, J.E.4    Panchal, B.C.5    Schaeffer, T.R.6    Fox, M.7    Giancarli, M.R.8    Cheung, H.S.9
  • 24
    • 85069133877 scopus 로고    scopus 로고
    • Characterization of ER-32935, a novel dual inhibitor of neutral endopeptidase and angiotensin I-converting enzyme
    • Abst P-351
    • Matsuoka, T. et al. Characterization of ER-32935, a novel dual inhibitor of neutral endopeptidase and angiotensin I-converting enzyme. Jpn J Pharmacol 1996, 71(Suppl. 1): Abst P-351.
    • (1996) Jpn J Pharmacol , vol.71 , Issue.SUPPL. 1
    • Matsuoka, T.1
  • 25
    • 0025775217 scopus 로고
    • Mixed inhibitors of angiotensin-converting enzyme (EC 3.4.15.1) and enkephalinase (EC 3.4.24.11): Rational design, properties, and potential cardiovascular applications of glycopril and alatriopril
    • Gros, C., Noel, N., Souque, A., Schwartz, J.C., Danvy, D., Plaquevent, J.C., Duhamel, L., Duhamel, P., Lecomte, J.M., Bralet, J. Mixed inhibitors of angiotensin-converting enzyme (EC 3.4.15.1) and enkephalinase (EC 3.4.24.11): Rational design, properties, and potential cardiovascular applications of glycopril and alatriopril. Proc Natl Acad Sci USA 1991, 88: 4210-4.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4210-4214
    • Gros, C.1    Noel, N.2    Souque, A.3    Schwartz, J.C.4    Danvy, D.5    Plaquevent, J.C.6    Duhamel, L.7    Duhamel, P.8    Lecomte, J.M.9    Bralet, J.10
  • 26
    • 0027180453 scopus 로고
    • Application of a conformationally restricted Phe-Leu dipeptide mimetic to the design of a combined inhibitor of angiotensin I-converting enzyme and neutral endopeptidase 24.11
    • Flynn, G.A., Beight, D.W., Mehdi, S., Koehl, J.R., Giroux, E.L., French, J.F., Hake, P. W., Dage, R.C. Application of a conformationally restricted Phe-Leu dipeptide mimetic to the design of a combined inhibitor of angiotensin I-converting enzyme and neutral endopeptidase 24.11. J Med Chem 1993, 36: 2420-3.
    • (1993) J Med Chem , vol.36 , pp. 2420-2423
    • Flynn, G.A.1    Beight, D.W.2    Mehdi, S.3    Koehl, J.R.4    Giroux, E.L.5    French, J.F.6    Hake, P.W.7    Dage, R.C.8
  • 28
    • 0003315531 scopus 로고    scopus 로고
    • Pharmacology of the active metabolite of SLV-306 - A mixed inhibitor of NEP and ECE
    • Abst P 52.22
    • Meil, J., Wurl, M., Thormähler, D., Rose, H. Pharmacology of the active metabolite of SLV-306 - A mixed inhibitor of NEP and ECE. Naunyn-Schmied Arch Pharmacol 1998, 358(1, Suppl. 2): Abst P 52.22.
    • (1998) Naunyn-schmied Arch Pharmacol , vol.358 , Issue.1 SUPPL. 2
    • Meil, J.1    Wurl, M.2    Thormähler, D.3    Rose, H.4
  • 29
    • 0031627514 scopus 로고    scopus 로고
    • Benzofused macrocyclic lactams as triple inhibitors of endothelin-converting enzyme, neutral endopeptidase 24.11, and angiotensin-converting enzyme
    • Ksander, G.M., Savage, P., Trapani, A.J., Balwierczak, J.L., Jeng, A.Y. Benzofused macrocyclic lactams as triple inhibitors of endothelin-converting enzyme, neutral endopeptidase 24.11, and angiotensin-converting enzyme. J Cardiovasc Pharmacol 1998, 31(Suppl. 1): S71-3.
    • (1998) J Cardiovasc Pharmacol , vol.31 , Issue.SUPPL. 1
    • Ksander, G.M.1    Savage, P.2    Trapani, A.J.3    Balwierczak, J.L.4    Jeng, A.Y.5
  • 30
    • 0031042767 scopus 로고    scopus 로고
    • Meta-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors
    • Ksander, G.M., de Jesus, R., Yuan, A., Ghai, R.D., McMartin, C., Bohacek, R. Meta-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors. J Med Chem 1997, 40: 506-14.
    • (1997) J Med Chem , vol.40 , pp. 506-514
    • Ksander, G.M.1    De Jesus, R.2    Yuan, A.3    Ghai, R.D.4    McMartin, C.5    Bohacek, R.6
  • 31
    • 0006175547 scopus 로고    scopus 로고
    • The properties of enzyme inhibition by a novel dual inhibitor, SA6817, of neutral endopeptidase and angiotensin-converting enzyme
    • Abst P-28
    • Fujita, Y. et al. The properties of enzyme inhibition by a novel dual inhibitor, SA6817, of neutral endopeptidase and angiotensin-converting enzyme. Jpn J Pharmacol 1997, 73(Suppl. 1): Abst P-28.
    • (1997) Jpn J Pharmacol , vol.73 , Issue.SUPPL. 1
    • Fujita, Y.1
  • 32
    • 0031451967 scopus 로고    scopus 로고
    • Renal effects of SCH 54470: A triple inhibitor of ECE, ACE, and NEP
    • Vemulapalli, S. et al. Renal effects of SCH 54470: A triple inhibitor of ECE, ACE, and NEP. Cardiovasc Drug Rev 1997,15: 260.
    • (1997) Cardiovasc Drug Rev , vol.15 , pp. 260
    • Vemulapalli, S.1
  • 33
    • 85069129105 scopus 로고    scopus 로고
    • Synthesis and activity of novel phosphinic acid inhibitors of endothelin converting enzyme
    • (Aug 25-29, Orlando) Abst MEDI 018
    • Stamford, A.W. et al. Synthesis and activity of novel phosphinic acid inhibitors of endothelin converting enzyme. 212th ACS Natl Meet (Aug 25-29, Orlando) 1996, Abst MEDI 018.
    • (1996) 212th ACS Natl Meet
    • Stamford, A.W.1
  • 34
    • 0000326308 scopus 로고    scopus 로고
    • Supine mean arterial blood pressure (MAP) lowering and oral tolerance of BMS-186716, a new dual metalloprotease inhibitor of angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP), in healthy male subjects
    • Abst PIV-45
    • Liao, W., Delaney, C., Smith, R., Lubin, S., McNulty, S., Davis, K., Meier, A., Uderman, H. Supine mean arterial blood pressure (MAP) lowering and oral tolerance of BMS-186716, a new dual metalloprotease inhibitor of angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP), in healthy male subjects. Clin Pharmacol Ther 1997, 61(2): Abst PIV-45.
    • (1997) Clin Pharmacol Ther , vol.61 , Issue.2
    • Liao, W.1    Delaney, C.2    Smith, R.3    Lubin, S.4    McNulty, S.5    Davis, K.6    Meier, A.7    Uderman, H.8
  • 35
    • 24244432775 scopus 로고    scopus 로고
    • Dual metalloprotease inhibitor: Discovery and pharmacology of omapatrilat
    • Abst D15
    • Robl, J.A. Dual metalloprotease inhibitor: Discovery and pharmacology of omapatrilat. FASEB J 1998, 12(8): Abst D15.
    • (1998) FASEB J , vol.12 , Issue.8
    • Robl, J.A.1
  • 36
    • 0002908168 scopus 로고    scopus 로고
    • Dual metalloprotease inhibition during the development of left ventricular failure: Effects on left ventricular myocyte β-adrenergic response
    • Abst 2917
    • Thomas, C.V., Holzgrefe, H.H., Mukherjee, R. Hird, R.B., Walker, J.D., Hebbar, L., Powell, J.R., Spinale, F.G. Dual metalloprotease inhibition during the development of left ventricular failure: Effects on left ventricular myocyte β-adrenergic response. Circulation 1997, 96(8, Suppl.): Abst 2917.
    • (1997) Circulation , vol.96 , Issue.8 SUPPL.
    • Thomas, C.V.1    Holzgrefe, H.H.2    Mukherjee, R.3    Hird, R.B.4    Walker, J.D.5    Hebbar, L.6    Powell, J.R.7    Spinale, F.G.8


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