Investigation into the role of the serine protease HtrA in Yersinia pestis pathogenesis

FEMS Microbiology Letters

Volumn 186, Issue 2, 2000, Pages 281-286

  Williams, Kerstin ^a   Oyston, Petra C F ^b   Dorrell, Nick ^a   Li, Shu Rui ^a   Titball, Richard W ^b   Wren, Brendan W ^a  

^a Dept Infect Trop Dis London S ^*  (United Kingdom)

^b DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

HtrA; Isogenic mutant; Pathogenesis; Stress response; Yersinia pestis

Indexed keywords

BACTERIAL ENZYME; SERINE PROTEINASE;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM MUTANT; CONTROLLED STUDY; ESCHERICHIA COLI; FEMALE; GENE AMPLIFICATION; GENE SEQUENCE; HIGH TEMPERATURE; LETHALITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENICITY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALMONELLA TYPHIMURIUM; STRESS; TEMPERATURE; YERSINIA PESTIS;

ANIMALS; BACTERIAL PROTEINS; BACTERIAL VACCINES; HEAT-SHOCK PROTEINS; MICE; MICE, INBRED BALB C; PERIPLASMIC PROTEINS; PLAGUE; POLYMERASE CHAIN REACTION; SERINE ENDOPEPTIDASES; VIRULENCE; YERSINIA PESTIS;

ANIMALIA; ESCHERICHIA COLI; SALMONELLA TYPHIMURIUM; SIPHONAPTERA (FLEAS); TYPHIMURIUM; YERSINIA PESTIS;

EID: 0034607971     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(00)00158-0     Document Type: Article

References (32)

1. Perry R.D., Fetherston J.D. Yersinia pestis-etiologic agent of plague. Clin. Microbiol. Rev. 10:1997;35-66.
2. Chanteau S., Ratsifasoamanana L., Rasoamanana B., Rahalison L., Randriambelosoa J., Roux J., Rabeson D. Plague, a re-emerging disease in Madagascar. Emerg. Infect. Dis. 4:1998;101-104.
3. McCormick J.B. Epidemiology of emerging/re-emerging antimicrobial-resistant bacterial pathogens. Curr. Opin. Microbiol. 1:1998;125-129.
4. Iriarte M., Cornelis G.R. Molecular determinants of Yersinia pathogenesis. Microbiologia. 12:1996;267-280.
5. Cornelis G.R., Boland A., Boyd A.P., Geuijen C., Iriarte M., Neyt C., Sory M.P., Stainier I. The virulence plasmid of Yersinia, an antihost genome. Microbiol. Mol. Biol. Rev. 62:1998;1315-1352.
6. Bearden S.W., Perry R.D. The Yfe system of Yersinia pestis transports iron and manganese and is required for full virulence of plague. Mol. Microbiol. 32:1999;403-414.
7. Pallen M.J., Wren B.W. The HtrA family of serine proteases. Mol. Microbiol. 26:1997;209-221.
8. Johnson K., Charles I., Dougan G., Pickard D., O'Gaora P., Costa G., Ali T., Miller I., Hormaeche C. The role of a stress-response protein in Salmonella typhimurium virulence. Mol. Microbiol. 5:1991;401-407.
9. Li S.R., Dorrell N., Everest P.H., Dougan G., Wren B.W. Construction and characterization of a Yersinia enterocolitica O:8 high-temperature requirement (htrA) isogenic mutant. Infect. Immun. 64:1996;2088-2094.
10. Elzer P.H., Phillips R.W., Kovach M.E., Peterson K.M., Roop II R.M. Characterization and genetic complementation of a Brucella abortus high-temperature-requirement A (htrA) deletion mutant. Infect. Immun. 62:1994;4135-4139.
11. Chatfield S.N., Strahan K., Pickard D., Charles I.G., Hormaeche C.E., Dougan G. Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model. Microb. Pathog. 12:1992;145-151.
12. Elzer P.H., Phillips R.W., Robertson G.T., Roop II R.M. The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytes. Infect. Immun. 64:1996;4838-4841.
13. Oyston P.C.F., Russell P., Williamson E.D., Titball R.W. An aroA mutant of Yersinia pestis is attenuated in guinea-pigs, but virulent in mice. Microbiology. 142:1996;1847-1853.
14. Russell P., Eley S.M., Hibbs S.E., Manchee R.J., Stagg A.J., Titball R.W. A comparison of plague vaccine, USP and EV76 vaccine induced protection against Yersinia pestis in a murine model. Vaccine. 13:1995;1551-1556.
15. Straley S.C., Harmon P.A. Yersinia pestis grows within phagolysosomes in mouse peritoneal macrophages. Infect. Immun. 45:1984;655-659.
16. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
17. Wren B.W., Colby S.M., Cubberley R.R., Pallen M.J. Degenerate PCR primers for the amplification of fragments from genes encoding response regulators from a range of pathogenic bacteria. FEMS Microbiol. Lett. 99:1992;287-291.
18. Altschul S.F., Gish W., Miller W., Myers E.W., Lipman D.J. Basic local alignment search tool. J. Mol. Biol. 215:1990;403-410.
19. Wren B.W., Henderson J., Ketley J.M. A PCR-based strategy for the rapid construction of defined bacterial deletion mutants. BioTechniques. 16:1994;994-996.
20. Dorrell N., Gyselman V.G., Foynes S., Li S.R., Wren B.W. Improved efficiency of inverse PCR mutagenesis (IPCRM). BioTechniques. 21:1996;604-608.
21. Donnenberg M.S., Kaper J.B. Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector. Infect. Immun. 59:1991;4310-4317.
22. Reed L.J., Muench H. A simple method for estimating fifty percent endpoints. Am. J. Hyg. 27:1938;493-497.
23. Gorg A., Boguth G., Obermaier C., Posch A., Weiss W. Two-dimensional polyacrylamide gel electrophoresis with immobilized pH gradients in the first dimension (IPG-Dalt): the state of the art and the controversy of vertical versus horizontal systems. Electrophoresis. 16:1995;1079-1086.
24. Heukeshoven J., Dernick R. Improved silver staining procedure for fast staining in PhastSystem Development Unit. 1. Staining of sodium dodecyl sulfate gels. Electrophoresis. 9:1988;28-32.
25. Meyer K.F., Cavanaugh D.C., Bartelloni P.J., Marshall J.D. Jr. Plague immunization. I. Past and present trends. J. Infect. Dis. 129:1974;S13-18.
26. Marshall J.D. Jr., Bartelloni P.J., Cavanaugh D.C., Kadull P.J., Meyer K.F. Plague immunization. II. Relation of adverse clinical reactions to multiple immunizations with killed vaccine. J. Infect. Dis. 129:1974;S19-25.
27. Ernst R.K., Guina T., Miller S.I. How intracellular bacteria survive: surface modifications that promote resistance to host innate immune responses. J. Infect. Dis. 179:1999;S326-330.
28. Straley S.C., Skrzypek E., Plano G.V., Bliska J.B. Yops of Yersinia species pathogenic for humans. Infect. Immun. 61:1993;3105-3110.
29. Poquet I., Saint V., Seznac E., Simoes N., Bolotin A., Gruss A. HtrA is the unique surface housekeeping protease in Lactococcus lactis and is required for natural protein processing. Mol. Microbiol. 35:2000;1042-1051.
30. Lowe D.C., Savidge T.C., Pickard D., Eckmann L., Kagnoff M.F., Dougan G., Chatfield S.N. Characterization of candidate live oral Salmonella typhi vaccine strains harboring defined mutations in aroA, aroC, and htrA. Infect. Immun. 67:1999;700-707.
31. Miller V.L., Mekalanos J.J. A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer-membrane proteins and virulence determinants in Vibrio cholerae requires ToxR. J. Bacteriol. 170:1988;2575-2583.
32. Grinter N.J. A broad host range cloning vector transposable to various replicons. Gene. 21:1983;133-143.