Structure and behavior in hydrophilic matrix sustained release dosage forms: 4. Studies of water mobility and diffusion coefficients in the gel layer of HPMC tablets using NMR imaging

Pharmaceutical Research

Volumn 13, Issue 3, 1996, Pages 376-380

  Rajabi Siahboomi, Ali R ^a,b   Bowtell, Richard W ^a   Mansfield, Peter ^a   Davies, Martyn C ^a   Melia, Colin D ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

Author keywords

Hydrophilic matrix; Hydroxypropylmethylcellulose (HPMC); NMR imaging; NMR microscopy; Self diffusion coefficient; T2 relaxation; Water mobility

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; METHOCEL E4M; METHOCEL F4M; UNCLASSIFIED DRUG;

ARTICLE; DIFFUSION; DIFFUSION COEFFICIENT; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; GEL; HYDRATION; LEISURE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TABLET; WATER FLOW;

CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; DELAYED-ACTION PREPARATIONS; GELS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; METHYLCELLULOSE; STRUCTURE-ACTIVITY RELATIONSHIP; TABLETS; WATER;

EID: 0029978132     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016084224084     Document Type: Article

References (15)

1. C. D. Melia, Hydrophilic matrix sustained release systems based on polysaccharides carriers. Crit. Rev. Ther. Drug Carrier Systems 8:395-421 (1991).
2. C. D. Melia, A. C. Hodsdon, M. C. Davies, J. R. Mitchell, Polymer concentration profiles of the surface gel layer of xanthan, alginate and HPMC matrix systems. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 21:724-725 (1994).
3. C. D. Melia, J. S. Binns, M. C. Davies, Polymer hydration and drug distribution within the gel layer of hydrophilic matrix devices during drug release. J. Pharm. Pharmacol. 42:125P (1990).
4. A. C. Hodsdon, J. R. Mitchell, M. C. Davies, C. D. Melia, Structure and behaviour in hydrophilic matrix sustained release dosage forms: 3. The influence of pH on the sustained-release performance and internal gel structure of sodium alginate matrices. J. Controlled Release 33:143-152 (1995).
5. C. D. Melia, A. R. Rajabi-Siahboomi, A. C. Hodsdon, J. Adler and J. R. Mitchell, Structure and behaviour in hydrophilic matrix sustained release dosage forms: 1. The origin and mechanism of formation of gas bubbles in the hydrated surface layer. Int. J. Pharm. 100:263-269 (1994).
6. R. W. Korsmeyer, E. D. Von Meerwall and N. A. Peppas, Diffusion in swellable drug delivery systems. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 12:81-82 (1985).
7. A. R. Rajabi-Siahboomi, R. W. Bowtell, P. Mansfield, A. Henderson, M. C. Davies and C. D. Melia, Structure and behaviour in hydrophilic matrix sustained release dosage forms: 2. NMR-imaging studies of dimensional changes in the gel layer and core of HPMC matrices undergoing hydration. J. Controlled Release 31:121-128 (1994).
8. R. W. Bowtell, J. C. Sharp, A. Peters, P. Mansfield, A. R. Rajabi-Siahboomi, M. C. Davies and C. D. Melia, NMR Microscopy of hydrating hydrophilic matrix pharmaceutical tablets. Mag. Res., Imaging 12:361-364 (1994).
9. R. A. Meyer and T. R. Brown, Diffusion measurements by microscopic NMR imaging. J. Mag. Res. 76:393-399 (1988).
10. L. A. Weisenberger and J. L Koenig, NMR imaging of diffusion processes in polymers: Measurement of spatial dependence of solvent mobility in partially swollen PMMA rods. Macromolecules 23:2445-2453 (1990).
11. D. Hariharan, N. A. Peppas, Modelling of water transport and solute release in physiologically sensitive gels. J. Controlled Release 23:123-136 (1993).
12. st UKaps Conf." 1992 Eds Hadgraft J., Kellaway I. W., Parr G. D. STS Publishing, Cardiff, UK pp 34.
13. D. A. Alderman, A review of cellulose ethers in hydrophilic matrices for oral controlled release dosage forms. Int. J. Pharm. Tech. Prod. Mft. 5:1-9 (1984).
14. P. Colombo, P. L Catellani, N. A. Peppas, L. Maggi and U. Conte, Swelling characteristics of hydrophilic matrices for controlled release: New dimensionless number to describe the swelling and release behaviour. Int. J. Pharm. 88:99-109 (1992).
15. K. Mitchell, J. Ford, C. Rostron, D. Armstrong, P. Elliott and J. Hogan, Swelling behaviour of cellulose ether matrix tablets. J. Pharm. Pharmacol. Suppl. 43:77P (1991).