Spontaneous release of cytosolic proteins from posttranslational substrates before their transport into the endoplasmic reticulum

Journal of Cell Biology

Volumn 151, Issue 1, 2000, Pages 167-178

  Plath, Kathrin ^a,b   Rapoport, Tom A ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cytosolic chaperones; Endoplasmic reticulum; Posttranslational protein translocation; Sec complex; Yeast

Indexed keywords

CHAPERONIN; CYTOSOL RECEPTOR; HEAT SHOCK PROTEIN; SIGNAL RECOGNITION PARTICLE;

ARTICLE; CROSS LINKING; ENDOPLASMIC RETICULUM; NONHUMAN; PHOTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN SECRETION; TRANSLATION REGULATION; YEAST;

CHAPERONINS; CROSS-LINKING REAGENTS; CYTOSOL; ENDOPLASMIC RETICULUM; FUNGAL PROTEINS; MODELS, BIOLOGICAL; MOLECULAR CHAPERONES; PROTEIN BIOSYNTHESIS; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; RIBOSOMES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL RECOGNITION PARTICLE; TRANS-ACTIVATORS;

EID: 0034597099     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.151.1.167     Document Type: Article

References (26)

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2. A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome
3. YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism
4. 70K heat shock related proteins stimulate protein translocation into microsomes
5. Dissociation of complexes between 70 kDa stress proteins and presecretory proteins is facilitated by a cytosolic factor
6. A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides
7. Complexes between nascent polypeptides and their molecular chaperones in the cytosol of mammalian cells
8. Residues in chaperonin GroEL required for polypeptide binding and release
9. Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones
10. Principles of chaperone-assisted protein folding: Differences between in vitro and in vivo mechanisms
11. The chaperone cofactor Hop/p60 interacts with the cytosolic chaperonin-containing TCP-1 and affects its nucleotide exchange and protein folding activities
12. Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins
13. Cytosolic chaperonin subunits have a conserved ATPase domain but diverged polypeptide-binding domains
14. Cytoplasmic chaperones determine the targeting pathway of precursor proteins to mitochondria
15. BiP acts as a molecular ratchet during posttranslational transport of prepro-alpha factor across the ER membrane
16. The interaction of the chaperonin tailless complex polypeptide 1 (TCP1) ring complex (TRiC) with ribosome-bound nascent chains examined using photo-cross-linking
17. Protein folding in the cytosol: Chaperonin-dependent and -independent mechanisms
18. Signal sequences specify the targeting route to the endoplasmic reticulum membrane
19. Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p
20. The molecular chaperone Ssb from Saccharomyces cerevisiae is a component of the ribosome-nascent chain complex
21. Signal sequence recognition in posttranslational protein transport across the yeast ER membrane
22. In vivo newly translated polypeptides are sequestered in a protected folding environment
23. Loss of Bip/Grp78 function blocks translocation of secretory proteins in yeast
24. Direct probing of the interaction between the signal sequence of nascent preprolactin and the signal recognition particle by specific cross-linking
25. A protein complex required for signal-sequence-specific sorting and translocation
26. Seventy-kilodalton heat shock proteins and an additional component from reticulocyte lysate stimulate import of M13 procoat into microsomes