Expression of cytochrome CYP2B1/2 in nonpregnant, pregnant and fetal rats exposed to tobacco smoke

Acta Biochimica Polonica

Volumn 47, Issue 4, 2000, Pages 1115-1127

  Czekaj, Piotr ^a,c   Wiaderkiewicz, Anna ^a   Florek, Ewa ^b   Wiaderkiewicz, Ryszard ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

^b POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^c NONE   (Poland)

Author keywords

CYP2B1 2; CYP2B6; Cytochrome P450; Pregnancy; Rats; Tobacco smoke

Indexed keywords

COTININE; CYTOCHROME P450; CYTOCHROME P450 2B1; MESSENGER RNA; NICOTINE; STEROID 16 BETA HYDROXYLASE; STEROID 16-BETA-HYDROXYLASE; STEROID MONOOXYGENASE; UNSPECIFIC MONOOXYGENASE;

ANIMAL; ARTICLE; BIOSYNTHESIS; BREEDING; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; LIVER; LUNG; METABOLISM; PLACENTA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PREGNANCY; PRENATAL DEVELOPMENT; RAT; SMOKING; WISTAR RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; COTININE; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 ENZYME SYSTEM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HUMANS; LIVER; LUNG; MATERNAL EXPOSURE; NICOTINE; PLACENTA; PREGNANCY; PREGNANCY, ANIMAL; RATS; RATS, WISTAR; RNA, MESSENGER; SMOKING; STEROID HYDROXYLASES;

EID: 0034585638     PISSN: 0001527X     EISSN: None     Source Type: Journal    
DOI: 10.18388/abp.2000_3964     Document Type: Article

References (43)

1. Gonzalez, F. & Gelboin, H. (1994) Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. Drug Metab. Rev. 26, 165-183.
2. Mori, Y., Iimura, K., Furukawa, F., Nishikawa, A., Takahashi, M. & Konishi, Y. (1995) Effect of cigarette smoke on the mutagenic activation of various carcinogens in hamster. Mutat. Res. 346, 1-8.
3. Miller, M., Warner, S., Jorquera, R., Castonguay, A. & Schüller, H. (1992) Expression of the cytochrome P4502E and 2B gene families in the lungs and livers of nonpregnant, pregnant, and fetal hamsters. Biochem. Pharmacol. 44, 797-803.
4. Whitlock, J. & Denison, M. (1995) Induction of cytochrome P450 enzymes that metabolize xenobiotics; in Cytochrome P450: Structure, Mechanisms and Biochemistry (Ortiz de Montellano P., ed.) pp. 367-390, Plenum Press, New York and London.
5. Kawamoto, T., Yoshikawa, M., Matsuno, K., Kayama, F., Oyama, T., Arashidani, K. & Kodama, Y. (1993) Effect of side-stream cigarette smoke on the hepatic cytochrome P450. Arch. Environ. Contam. Toxicol. 25, 255-259.
6. Villard, P., Seree, E., Re, J., DeMeo, M., Barra, Y., Attolini, L., Dumenil, G., Catalin, J., Durand, A. & Lacarelle, B. (1998) Effects of tobacco smoke on the gene expression of the CYP1a, CYP2b, CYP2e and CYP3a subfamilies in mouse liver and lung: Relation to single strand breaks of DNA. Toxicol Appl. Pharmacol. 148, 195-204.
7. Gonzalez, F. (1989) The molecular biology of cytochrome P450s. Pharmacol. Rev. 40, 243-288.
8. de Montellano, O. (1995) Cytochrome P450. Structure, Mechanism, and Biochemistry (Ortiz de Montellano P., ed.) p. 608, Plenum Press, New York and London.
9. Omiecinski, C., Walz, F. & Vlasuk, G. (1985) Phenobarbital induction of rat liver cytochromes P-450b and P-450e. Quantitation of specific RNAs by hybridization to synthetic oligodeoxyribonucleotide probes. J. Biol. Chem. 260, 3247-3250.
10. Honkakoski, P., Zelko, I., Sueyoshi, T. & Negishi, M. (1998) The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol. Cell. Biol. 18, 5652-5658.
11. Enmrak, E. & Gustafsson, J. (1996) Orphan nuclear receptors - the first eight years. Mol. Endocrinol. 10, 1293-1307.
12. Czekaj, P. & Plewka, A. (1990) Porównanie aktywności wa̧trobowego i nerkowego układu oksydaz o funkcji mieszanej (MFO) w różnych okresach życia pozapłodowego szczurów. Folia Med. Cracov. XXXI, 3, 225-236 (in Polish).
13. Horbach, J., van Asten, J. & van Bezooijen, C. (1990) The influence of ageing on the induction of the mRNAs of rat liver cytochromes P450IIB1 and P450IIB2. Biochem. Pharmacol. 40, 529-533.
14. Honkakoski, P. & Negishi, M. (1997) Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene. J. Biol. Chem. 272, 14943-14949.
15. Czekaj, P., Plewka, A, Krzyżak, G., Plewka, D. & Kamiński, M. (1989) Studies on circadian rhythm of microsomal ingredients of transport electron chains in young rats. Rev. Roum. Biochim. 26, 19-26.
16. Czekaj, P., Plewka, A., Kamiński, M., Nowaczyk-Dura, G., Pawlicki, K. & Wielgus-Serafińska, E. (1994) Daily and circadian rhythms in the activity of mixed function oxidases system in rats of different age. Biol. Rhythm Res. 25, 1-9.
17. Dallner, G. (1974) Isolation of rough and smooth microsomes - general. Methods Enzymol. 32, 191-215.
18. Lowry, O., Rosebrough, N., Farr, A. & Randall, R. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
19. Laemmli, U. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
20. Omura, T. & Sato, R. (1964) The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 239, 2370-2378.
21. Hodges, T. & Leonard, R. (1974) Purification of a plasma membrane-bound adenosine triphosphatase from plant roots. Methods Enzymol. 32, 392-406.
22. Burke, M., Thompson, S., Elcombe, C., Halpert, J., Haaparanta, T. & Mayer, R. (1985) Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P-450. Biochem. Pharmacol. 34, 3337-3345.
23. Perkins, S., Livesey, J., Escares, E., Belcher, J. & Dudley, D. (1991) High-performance liquid-chromatographic method compared with a modified radioimmunoassay of cotinine in plasma. Clin. Chem. 37, 1989-1993.
24. Cresteil, T., Beaune, C., Celier, C., Leroux, J., Guengerich, F. (1986) Cytochrome P450 isoenzyme content and monooxygenase activities in rat liver: Effect of ontogenesis and pretreatment by phenobarbital and 3-methycholanthrene. J. Pharmacol. Exp. Ther. 236, 269-276.
25. Czekaj, P., Wiaderkiewicz, A. & Wiaderkiewicz, R. (2000) Immunodetection of cytochrome P450 isoforms in fetus and adult female Wistar rats. Acta Pol. Toxicol. 1, 17-31.
26. Omiecinski, C., Hassett, C., Costa, P. (1990) Developmental expression and in situ localization of the phenobarbital-inducible rat hepatic mRNAs for cytochromes CYP2B1, CYP2B2, CYP2C6, and CYP3A1. Mol. Pharmacol. 38, 462-470.
27. Ji, C., Cardoso, W., Gebremichael, A., Philpot, R., Buckpitt, A., Plopper, C. & Pinkerton, K. (1995) Pulmonary cytochrome P-450 monooxygenase system and Clara cell differentiation in rats. Am. J. Physiol. 269, L394-L402.
28. Gebremichael, A., Chang, A., Buckpitt, A., Plopper, C. & Pinkerton, K. (1995) Postnatal development of cytochrome P4501A1 and 2B1 in rat lung and liver: Effect of aged and diluted sidestream cigarette smoke. Toxicol. Appl. Pharmacol. 135, 246-253.
29. Stoltz, C., Vachon, M.-H., Trottier, E., Dubois, S., Paquet, Y. & Anderson, A. (1998) The CYP2B2 phenobarbital response unit contains an accessory factor element and a putative glucocorticoid response element essential for conferring maximal phenobarbital responsiveness. J. Biol. Chem. 273, 8528-8536.
30. Hardwick, J., Gonzalez, F. & Kasper, C. (1983) Transcriptional regulation of rat liver epoxide hydratase, NADPH-cytochrome P-450 oxidoreductase, and cytochrome P-450b genes by phenobarbital. J. Biol. Chem. 258, 8081-8085.
31. Honkakoski, P., Moore, R., Washburn, K. & Negishi, M. (1998) Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the Cyp2b10 gene. Mol. Pharmacol. 53, 597-601.
32. Wardlaw, S., Nikula, K., Kracko, D., Finch, G., Thornton-Manning, J. & Dahl, A. (1998) Effect of cigarette smoke on CYP1A1, CYP1A2 and CYP2B1/2 of nasal mucosae in F344 rats. Carcinogenesis 19, 655-662.
33. Annas, A. & Brittebo, E. (1998) Localization of cytochrome P4501A1 and covalent binding of a mutagenic heterocyclic amine in blood vessel endothelia of rodents. Toxicology 129, 145-156.
34. Serabjit-Singh, C., Nisho, S., Philpot, R. & Plopper, C. (1988) The distrubution of cytochrome P-450 monooxygenase in cells of rabbit lung: An ultrastructural immunocytochemical characterization. Mol. Pharmacol. 33, 279-289.
35. 5 in the oxidative metabolism of polychlorinated biphenyls catalyzed by cytochrome P450. Xenobiotica 26, 405-414.
36. Hakkola, J., Pasanen, M., Hukkanen, J., Pelkonen, O., Maenpaa, J., Edwards, R., Boobis, A. & Raunio, H. (1996) Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta. Biochem. Pharmacol. 51, 403-411.
37. Hakkola, J., Raunio, H., Purkunen, R., Pelkonen, O., Saarikoski, S., Cresteil, T. & Pasanen, M. (1996) Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy. Biochem. Pharmacol. 52, 379-383.
38. Pasanen, M. (1994) The expression and environmental regulation of P450 enzymes in human placenta. Crit. Rev. Toxicol. 24, 211-229.
39. Waxman, D. & Chang, T. (1995) Hormonal regulation of liver cytochrome P450 enzymes; in Cytochrome P450: Structure, Mechanisms and Biochemistry (Ortiz de Montellano, P., ed.) pp. 391-442, Plenum Press, New York and London.
40. Nebert, D. (1994) Drug-metabolizing enzymes in ligand-modulated transcription. Biochem. Pharmacol. 47, 25-37.
41. Borlakoglu, J., Scott, A., Henderson, C. & Wolf, C. (1993) Alterations in rat hepatic drug metabolism during pregnancy and lactation. Biochem. Pharmacol. 46, 29-36.
42. Lambert, G., Lietz, H. & Kotake, A. (1987) Effects of pregnancy on the cytochrome P-450 system in mice. Biochem. Pharmacol. 36, 1965-1971.
43. Nakajima, T., Wang, R.-S., Katakura, Y., Kishi, R., Elovaara, E., Park, S., Gelboin, H. & Vainio, H. (1992) Sex, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content. J. Pharmacol. Exp. Therap. 261, 869-874.