Topoisomerase IIα mediates E2F-1-induced chemosensitivity and is a target for p53-mediated transcriptional repression

Cell Biochemistry and Biophysics

Volumn 33, Issue 2, 2000, Pages 199-207

  Nip, John ^a   Hiebert, Scott W ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell cycle; E2F 1; p53; Topoisomerase

Indexed keywords

2,3 BIS(3,5 DIOXO 1 PIPERAZINYL)BUTANE; CARRIER PROTEIN; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE II ALPHA; E2F1 PROTEIN, HUMAN; ENZYME INHIBITOR; INTERLEUKIN 3; ISOENZYME; PIPERAZINE DERIVATIVE; PROTEIN P53; RAPAMYCIN; RETINOBLASTOMA BINDING PROTEIN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; TUMOR ANTIGEN;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL LINE; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSCRIPTION; HUMAN; METABOLISM; PHYSIOLOGY;

ANTIGENS, NEOPLASM; APOPTOSIS; CARRIER PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; CELL SURVIVAL; DNA TOPOISOMERASES, TYPE II; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; ENZYME INHIBITORS; HUMANS; INTERLEUKIN-3; ISOENZYMES; PIPERAZINES; SIROLIMUS; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034570214     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1385/CBB:33:2:199     Document Type: Conference Paper

References (49)

1. Adams, P. D. and Kaelin, W. G., Jr. (1995) Transcriptional control by E2F. Semin. Cancer Biol. 6, 99-108.
2. Dobrowolski, S. F., Stacey, D. W., Harter, M. L., Stine, J. T. and Hiebert, S. W. (1994) An E2F dominant negative mutant blocks E1A induced cell cycle progression. Oncogene 9, 2605-2612.
3. Johnson, D. G., Schwarz, J. K., Cress, W. D. and Nevins, J. R. (1993) Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365, 349-352.
4. Shan, B. and Lee. W. H. (1994) Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell. Biol. 14, 8166-8173.
5. Neuman, E., Sellers, W. R., McNeil, J. A., Lawrence, J. B. and Kaelin, W. G., Jr. (1996) Structure and partial genomic sequence of the human E2F1 gene. Gene 173, 163-169.
6. Hiebert, S. W., Chellappan, S. P., Horowitz, J. M. and Nevins, J. R. (1992) The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev. 6, 177-185.
7. Weintraub, S. J., Chow, K. N., Luo, R. X., Zhang, S. H., He, S. and Dean, D. C. (1995) Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375, 812-815.
8. Weintraub, S. J., Prater, C. A. and Dean. D. C. (1992) Retinoblastoma protein switches the E2F site from positive to negative element. Nature 358, 259-261.
9. Bremner, R., Cohen, B. L., Sopta, M., Hamel, P. A., Ingles, C. J., Gallie, B. L. and Phillips, R. A. (1995) Direct transcriptional repression by pRB and its reversal by specific cyclins. Mol. Cell. Biol. 15, 3256-3265.
10. Dynlacht, B. D., Flores, O., Lees, J. A. and Harlow, E. (1994) Differential regulation of E2F transactivation by cyclin/cdk2 complexes. Genes Dev. 8, 1772-1786.
11. Bandara, L. R., Buck, V. M., Zamanian, M., Johnston, L. H. and La Thangue, N. B. (1993) Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F. EMBO J 12, 4317-4324.
12. La Thangue, N. B. (1994) DP and E2F proteins: components of a heterodimeric transcription factor implicated in cell cycle control. Curr. Opin. Cell. Biol. 6, 443-450.
13. Pearson, B. E., Nasheuer, H. P. and Wang, T. S. (1991) Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells. Mol. Cell. Biol. 11, 2081-2095.
14. Blake, M. C. and Azizkhan, J. C. (1989) Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo. Mol. Cell. Biol. 9, 4994-5002.
15. Slansky, J. E. and Farnham, P. J. (1996) Transcriptional regulation of the dihydrofolate reductase gene. Bioessays 18, 55-62.
16. Slansky, J. E., Li, Y., Kaelin, W. G. and Farnham, P. J. (1993) A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol. Cell. Biol. 13, 1610-1618.
17. Dou, Q. P., Markell, P. J. and Pardee, A. B. (1992) Thymidine kinase transcription is regulated at G1/S phase by a complex that contains retinoblastoma-like protein and a cdc2 kinase. Proc. Natl. Acad. Sci. 89, 3256-3260.
18. Almasan, A., Yin, Y., Kelly, R. E., Lee, E. Y., Bradley, A., Li, W., Bertino, J. R. and Wahl, G. M. (1995) Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc. Natl. Acad. Sci. USA 92, 5436-5440.
19. DeGregori, J., Kowalik, T. and Nevins, J. R. (1995) Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol. Cell. Biol. 15, 4215-4224.
20. Ohtani, K., DeGregori, J. and Nevins, J. R. (1995) Regulation of the cyclin E gene by transcription factor E2F1. Proc. Natl. Acad. Sci. 92, 12,146-12,150.
21. Sala, A., Nicolaides, N. C., Engelhard, A., Bellon, T., Lawe, D. C., Arnold, A. et al. (1994) Correlation between E2F-1 requirement in the S phase and E2F-1 transactivation of cell cycle-related genes in human cells. Cancer Res. 54, 1402-1406.
22. Schulze, A., Zerfass, K., Spitkovsky, D., Middendorp, S., Berges, J., Helin, K., Jansen-Durr, P. and Henglein, B. (1995) Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. Proc. Natl. Acad. Sci. USA 92, 11,264-11,268.
23. Hannon, G. J. and Beach, D. (1994) p15INK4B is a potential effector of TGF-B-induced cell cycle arrest. Nature 371, 257-261.
24. Hunter, T. and Pines, J. (1994) Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell 79, 573-582.
25. Serrano, M., Hannon, G. J. and Beach, D. 1993. A new regulatory motif in cell-cycle control causing specific inhibition of cyclinD/cdk4. Nature 366, 704-707.
26. Sherr, C. J. and Roberts, J. M. (1995) Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9, 1149-1163.
27. Bates, S. and Peters, G. (1995) Cyclin D1 as a cellular proto-oncogene. Semin. Cancer Biol. 6, 73-82.
28. Delmer, A., Tang, R., Senamaud-Beaufort, C., Paterlini, P., Brechot, C. and Zittoun, R. (1995) Alterations of cyclin-dependent kinase 4 inhibitor (p16INK4A/MTS1) gene structure and expression in acute lymphoblastic leukemias. Leukemia 9, 1240-1245.
29. Gillett, C., Fantl, V., Smith R., Fisher, C., Bartek, J., Dickson, C., Barnes, D. and Peters, G. (1994) Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res. 54, 1812-1817.
30. Hangaishi, A., Ogawa, S., Imamura, N., Miyawaki, S., Miura, Y., Uike, N. et al. (1996) Inactivation of multiple tumor-suppressor genes involved in negative regulation of the cell cycle, MTS1/p16INK4A/CDKN2, MTS2/p15INK4B, p53, and Rb genes in primary lymphoid malignancies. Blood 87, 4949-4958.
31. Nakamaki, T., Kawamata, N., Schwaller, J., Tobler, A., Fey, M., Pakkala, S. et al. (1995) Structural integrity of the cyclin-dependent kinase inhibitor genes, p15, p16 and p18 in myeloid leukaemias. Br. J. Haematol. 91, 139-149.
32. Ogawa, S., Hirano, N., Sato, N. et al. (1994) Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias. Blood 84, 2431-2435.
33. Okuda, T., Shurtleff, S. A., Valentine, M. B. et al. (1995) Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia. Blood 85, 2321-2330.
34. Quesnel, B., Preudhomme, C. and Fenaux, P. (1996) p16ink4a gene and hematological malignancies. Leukemia Lymphoma 22, 11-24.
35. Kowalik, T. F., DeGregori, J., Schwarz, J. K. and Nevins, J. R. (1995) E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J. Virol. 69, 2491-2500.
36. Nip, J., Strom, D. K., Fee, B. E., Zambetti, G., Cleveland, J. L. and Hiebert, S. W. (1997) E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis. Mol. Cell. Biol. 17, 1049-1056.
37. Qin, X. Q., Livingston, D. M., Kaelin, W. G., Jr. and Adams, P. D. (1994) Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. 91, 10,918-10,922.
38. Holmberg, C., Helin, K., Sehested, M. and Karlström, O. (1998) E2F-1-induced p53-independent apoptosis in transgenic mice. Oncogene 17, 143-155.
39. Hiebert, S. W., Packham, G., Strom, D. K., Haffner, R., Oren, M., Zambetti, G. and Cleveland, J. L. (1995) E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis. Mol. Cell. Biol. 15, 6864-6874.
40. Hsieh, J. K., Fredersdorf, S., Kouzarides, T., Martin, K. and Lu. X. (1997) E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 11, 1840-1852.
41. Phillips, A. C., Bates, S., Ryan, K. M., Helin, K. and Vousden, K. H. (1997) Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev. 11, 1853-1863.
42. Wu, X. and Levine, A. J. (1994) p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. 91, 3602-3606.
43. Pierce, A. M., Fisher, S. M., Conti, C. J. and Johnson, D. G. (1998) Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development. Oncogene 16, 1267-1276.
44. Field, S. J., Tsai, F. Y., Kuo, F., Zubiaga, A. M., Kaelin, Jr., W. G., Livingston, D. M., Orkin, S. H. and Greenberg, M. E. (1996) E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85, 549-561.
45. Helin, K., Wu, C. L., Fattaey, A. R., Lees, J. A., Dynlacht, B. D., Ngwu, C. and Harlow, E. (1993) Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev. 7, 1850-1861.
46. Roca, J., Ishida, R., Berger, J. M., Andoh, T. and Wang, J. C. (1994) Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp. Proc. Natl. Acad. Sci. USA 91, 1781-1785.
47. Wang, Q., Zambetti, G. P. and Suttle, D. P. (1997) Inhibition of DNA topoisomerase IIα gene expression by the p53 tumor suppressor. Mol. Cell. Biol. 17, 389-397.
48. An, W. G., Kanekal, M., Simon, M. C., Maltepe, E., Blagosklonny, M. V. and Neckers, L. M. (1998) Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature 392, 405-408.
49. DeGregori, J., Leone, G., Miron, A., Jakoi, L. and Nevins, J. R. (1997) Distinct roles for E2F proteins in cell growth control and apoptosis. Proc. Natl. Acad. Sci. USA 94, 7245-7250.