Angiogenic interactions of vascular endothelial growth factor, of thymidine phosphorylase, and of p53 protein expression in locally advanced gastric cancer

Oncology Research

Volumn 12, Issue 1, 2000, Pages 33-41

  Giatromanolaki, A ^a,b   Koukourakis, M I ^a,c   Stathopoulos, G P ^e   Kapsoritakis, A ^a   Paspatis, G ^a,d   Kakolyris, S ^c   Sivridis, E ^a,b   Georgoulias, V ^d   Harris, A L ^a,f   Gatter, K C ^a,f  

^a Tumour and Angiogenesis Research Group Iraklion   (Greece)

^b DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^c University of Thessaly School of Medicine   (Greece)

^d Venizelion General Hospital   (Greece)

^e UNIVERSITY OF ATHENS   (Greece)

^f OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Angiogenesis; Gastric cancer; p53; Platelet derived endothelial cell growth factor (PD ECGF); Thymidine phosphorylase; VEGF

Indexed keywords

ENDOTHELIAL CELL GROWTH FACTOR; LYMPHOKINE; PROTEIN P53; THYMIDINE PHOSPHORYLASE; VASCULOTROPIN; VASCULOTROPIN A;

ADENOCARCINOMA; ARTICLE; BIOPSY; COMPARATIVE STUDY; ENZYME IMMUNOASSAY; HUMAN; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PROGNOSIS; STOMACH TUMOR; SURVIVAL; VASCULARIZATION;

ADENOCARCINOMA; BIOPSY; ENDOTHELIAL GROWTH FACTORS; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHOKINES; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS; STOMACH NEOPLASMS; SURVIVAL ANALYSIS; THYMIDINE PHOSPHORYLASE; TUMOR SUPPRESSOR PROTEIN P53; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0034567764     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000001108747426     Document Type: Article

References (53)

1. Craft, P. S.; Harris, A. L. Clinical prognostic significance of tumour angiogenesis. Ann. Oncol. 5:305-311; 1994.
2. Guidi, A.; Abu-Jawdeh, G.; Berse, B.; Jackman, R. W.; Tognazzi, K.; Dvorak, H. F.; Brown, L. F. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia. J. Natl. Cancer Inst. 87:1237-1245; 1995.
3. Koukourakis, M. I.; Giatromanolaki, A.; O'Byrne, K.; Comley, M.; Whitehouse, R.; Talbot, D. C.; Gatter, K. C.; Harris, A. L. Platelet-derived endothelial cell growth factor expression correlates with tumour angiogenesis and prognosis in non-small cell lung cancer. Br. J. Cancer 4:477-481; 1997.
4. Takahashi, Y.; Bucana, C. D.; Liu, W.; Yoneda, J.; Kitadai, Y.; Clearly, K. R.; Ellis, L. M. Platelet-derived endothelial cell growth factor in human colon cancer angiogenesis: Role of infiltrating cells. J. Natl. Cancer Inst. 88:1146-1151; 1996.
5. Toi, M.; Hoshina, S.; Taniguchi, T.; Yamamoto, Y.; Ishitsuka, H.; Tominaga, T. Vascular endothelial growth factor and platelet derived endothelial cell growth factor are frequently coexpressed in highly vascularized human breast cancer. Clin. Cancer Res. 1: 961-964; 1995.
6. Giatromanolaki, A., Koukourakis, M. I.; Kakolyris, S.; Kakolyris, S.; Turley, H.; O'Byrne, K.; Scott, P. A. E.; Pezzella, F.; Gorgoulias, V.; Harris, A. L.; Gatter, K. C. Vascular endothelial growth factor, wild-type p53 and angiogenesis in early operable non-small cell lung cancer. Clin. Cancer Res. 4:3017-3024; 1998.
7. Dameron, K. N.; Volpert, O. V.; Tainsky, M. A.; Bouck, N. Control of angiogenesis fibroblasts by p53 regulation of thrombospondin-1. Science 265:1582-1584; 1994.
8. Lawrence, W., Jr.; Menck, H. R.; Steele, G. D., Jr.; Winchester, D. P. The National Cancer Data Base report on gastric cancer. Cancer 75:1734-1744; 1995.
9. Wils, J. Treatment of gastric cancer. Curr. Opin. Oncol. 10:357-361; 1998.
10. Ajani JA. Chemotherapy for gastric carcinoma: New and old options. Oncology 12(Suppl. 7):44-47; 1998.
11. Harris, A. L. Anti-angiogenesis therapy and strategies for integrating it with adjuvant therapy. Recent Results Cancer Res. 152:341-352; 1998.
12. Borgström, P.; Hillan, K. J.; Sriramarao, P.; Ferrara, N. Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy. Cancer Res. 56:4032-4039; 1996.
13. Presta, L. G.; Chen, H.; O'Connor, S. J.; Chisholm, V.; Meng, Y. G.; Krummen, L.; Winkler, M.; Ferrara, N. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 57: 4593-4599; 1997.
14. Hirota, K.; Sawada, M.; Sajiki, H.; Sako, M. Synthesis of 6-aminouracils and pyrrolo(2,3-d)pyrimidine-2,4-diones and their inhibitory effect on thymidine phosphorylase. Nucleic Acids Symp. Ser. 37:59-60; 1997.
15. Balzarini, J.; Gamboa, A. E.; Esnouf, R.; Liekens, S.; Neyts, J.; De Clercq, E.; Camarasa, M. J.; Pérez-Pérez, M. J. 7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase. FEBS Lett. 438:91-95; 1998.
16. Ishikawa, T.; Sekiguchi, F.; Fukase, Y.; Sawada, N.; Ishitsuka, H. Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts. Cancer Res. 58:685-690; 1998.
17. Blum, J. L.; Jones, S. E.; Buzdar, A. U.; LoRusso, P. M.; Kuter, I.; Vogel, C.; Osterwalder, B.; Burger, H. U.; Brown, C. S.; Griffin, T. Multicenter phase II study of capecitabine in paclitaxel-refractory metastatic breast cancer. J. Clin. Oncol. 17:485-493; 1999.
18. Zou, Y.; Zong, G.; Ling, Y. H.; Hao, M. M.; Lozano, G.; Hong, W. K.; Perez-Soler, R. Effective treatment of early endobronchial cancer with regional administration of liposome-p53 complexes. J. Natl. Cancer Inst. 90:1130-1137; 1998.
19. Nguyen, D. M.; Spitz, F. R.; Yen, N.; Cristiano, R. J.; Roth, J. A. Gene therapy for lung cancer: Enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer. J. Thorac. Cardiovasc. Surg. 112: 1372-1376; 1996.
20. Siim, B. G.; van Zijl, P. L.; Brown, J. M. Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro. Br. J. Cancer 73: 952-960; 1996.
21. Siemann, D. W.; Hinchman, C. A. Potentiation of cisplatin activity by the bioreductive agent tirapazamine. Radiother. Oncol. 47: 215-220; 1998.
22. Maehara, Y.; Hasuda, S.; Abe, T.; Oki, E.; Kakeji, Y.; Ohno, S.; Sugimachi, K. Tumor angiogenesis and micrometastasis in bone marrow of patients with early gastric cancer. Clin. Cancer Res. 4: 2129-2134; 1998.
23. Xiangming, C.; Hokita, S.; Natsugoe, S.; Tanabe, G.; Baba, M.; Takao, S.; Kuroshima, K.; Aikou, T. Angiogenesis as an unfavorable factor related to lymph node metastasis in early gastric cancer. Ann. Surg. Oncol. 5:585-589; 1998.
24. Araya, M.; Terashima, M.; Takagane, A.; Abe, K.; Nishizuka, S.; Yonezawa, H.; Irinoda, T.; Nakaya, T.; Saito, K. Microvessel count predicts metastasis and prognosis in patients with gastric cancer. J. Surg. Oncol. 65:232-236; 1998.
25. Tanigawa, N.; Amaya, H.; Matsumura, M.; Shimomatsuya, T.; Horiuchi, T.; Muraoka, R.; Iki, M. Extent of tumor vascularization correlates with prognosis and hematogenous metastasis in gastric carcinomas. Cancer Res. 56:2671-2676; 1996.
26. Maeda, K.; Chung, Y. S.; Takatsuka, S.; Ogawa, Y.; Onoda, N.; Sawada, T.; Kato, Y.; Nitta, A.; Arimoto, Y.; Kondo, Y. Tumour angiogenesis and tumour cell proliferation as prognostic indicators in gastric carcinoma. Br. J. Cancer 72:319-323; 1995.
27. Maeda, K.; Chung, Y. S.; Takatsuka, S.; Ogawa, Y.; Sawada, T.; Yamashita, Y.; Onoda, N.; Kato, Y.; Nitta, A.; Arimoto, Y. Tumor angiogenesis as a predictor of recurrence in gastric carcinoma. J. Clin. Oncol. 13:477-481; 1995.
28. Ohtani, H.; Nakamura, S.; Watanabe, Y.; Mizoi, T.; Saku, T.; Nagura, H. Immunocytochemical localization of basic fibroblast growth factor in carcinomas and inflammatory lesions of the human digestive tract. Lab. Invest. 68:520-527; 1993.
29. Takahashi, Y.; Cleary, K. R.; Mai, M.; Kitadai, Y.; Bucana, C. D.; Ellis, L. M. Significance of vessel count and vascular endothelial growth factor and its receptor (KDR) in intestinal-type gastric cancer. Clin. Cancer Res. 2:1679-1684; 1996.
30. Takahashi, Y.; Bucana, C. D.; Akagi, Y.; Liu, W.; Cleary, K. R.; Mai, M.; Ellis, L. M. Significance of platelet-derived endothelial cell growth factor in the angiogenesis of human gastric cancer. Clin. Cancer Res. 4:429-434; 1998.
31. Takebayashi, Y.; Miyadera, K.; Akiyama, S.; Hokita, S.; Yamada, K.; Akiba, S.; Yamada, Y.; Sumizawa, T.; Aikou, T. Expression of thymidine phosphorylase in human gastric carcinoma. Jpn. J. Cancer Res. 87:288-295; 1996.
32. Maeda, K.; Chung, Y. S.; Ogawa, Y.; Takatsuka, S.; Kang, S. M.; Ogawa, M.; Sawada, T.; Sowa, M. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma. Cancer 77:858-863; 1996.
33. Maeda, K.; Chung, Y. S.; Ogawa, Y.; Takatsuka, S.; Kang, S. M.; Ogawa, M.; Sawada, T.; Onoda, N.; Kato, Y.; Sowa, M. Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma. Br. J. Cancer 73:884-888; 1996.
34. Tomoda, M.; Maehara, Y.; Kakeji, Y.; Ohno, S.; Ichiyoshi, Y.; Sugimachi, K. Intratumoral neovascularization and growth pattern in early gastric carcinoma. Cancer 85:2340-2346; 1999.
35. Tanigawa, N.; Amaya, H.; Matsumura, M.; Katoh, Y.; Kitaoka, A.; Aotake, T.; Shimomatsuya, T.; Rosenwasser, O. A.; Iki, M. Tumor angiogenesis and expression of thymidine phosphorylase/platelet derived endothelial cell growth factor in human gastric carcinoma. Cancer Lett. 108:281-290; 1996.
36. Bouvet, M.; Ellis, L. M.; Nishizaki, M.; Fujiwara, T.; Liu, W.; Bucana, C. D.; Fang, F.; Lee, J. J.; Roth, J. A. Adenovirus-mediated wild type p53 gene transfer down-regulates vascular endothelial growth factor expression and angiogenesis in human colon cancer. Cancer Res. 58:2288-2292; 1998.
37. Fontanini, G.; Vignati, S.; Lucchi, M.; Mussi, A.; Calcinai, A.; Boldrini, L.; Chine, S.; Silvestri, V.; Angeletti, C. A.; Basolo, F.; Bevilacqua, G. Neoangiogenesis and p53 protein in lung cancer: Their prognostic role and their relation with vascular endothelial cell growth factor (VEGF) expression. Br. J. Cancer 75:1295-1301; 1997.
38. Giatromanolaki, A.; Fountzilas, G.; Koukourakis, M. I.; Arapandoni, P.; Theologi, V.; Kakolyris, S.; Georgoulias, V.; Harris, A. L.; Gatter, K. C. Neo-angiogenesis in locally advanced squamous cell head and neck cancer correlates with thymidine phosphorylase expression and p53 nuclear oncoprotein accumulation. Clin. Exp. Metastasis 16:665-672; 1998.
39. Vermeulen, P. B.; Roland, L.; Mertens, V.; Van Marck, E.; De Bruijn, E. A.; Van Oosterom, A. T.; Dirix, L. Y. Correlation of intratumoral microvessel density and p53 protein overexpression in human colorectal adenocarcinoma. Microvasc. Res. 51:164-174; 1996.
40. Maeda, K.; Kang, S. M.; Onoda, N.; Ogawa, M.; Sawada, T.; Nakata, B.; Kato, Y.; Chung, Y. S.; Sowa, M. Expression of p53 and vascular endothelial growth factor associated with tumor angiogenesis and prognosis in gastric cancer. Oncology 55:594-599; 1998.
41. Toi, M.; Inada, K.; Hoshina, S.; Suzuki, H.; Kondo, S.; Tominaga, T. Vascular endothelial growth factor and platelet-derived endothelial cell growth factor are frequently coexpressed in highly vascularized human breast cancer. Clin. Cancer Res. 1:961-964; 1995.
42. Amaya, H.; Tanigawa, N.; Lu, C.; Matsumura, M.; Shimomatsuya, T.; Horiuchi, T.; Muraoka, R. Association of vascular endothelial growth factor expression with tumor angiogenesis, survival and thymidine phosphorylase/platelet-derived endothelial cell growth factor expression in human colorectal cancer. Cancer Lett. 119:227-235; 1997.
43. Fukuiwa, T.; Takebayashi, Y.; Akiba, S.; Matsuzaki, T.; Hanamure, Y.; Miyadera, K.; Yamada, Y.; Akiyama, S. Expression of thymidine phosphorylase and vascular endothelial cell growth factor in human head and neck squamous cell carcinoma and their different characteristics. Cancer 85:960-969; 1999.
44. Maeda, K.; Kang, S. M.; Ogawa, M.; Onoda, N.; Sawada, T.; Nakata, B.; Kato, Y.; Chung, Y. S.; Sowa, M. Combined analysis of vascular endothelial growth factor and platelet-derived endothelial cell growth factor expression in gastric carcinoma. Int. J. Cancer 74:545-550; 1997.
45. Koukourakis, M. I.; Giatromanolaki, A.; Kakolyris, S.; O'Byrne, K.; Apostolikas, T.; Skarlatos, J.; Gatter, K. C.; Harris, A. L. Different patterns of stromal and cancer cell thymidine phosphorylase reactivity in non small cell lung cancer. Impact on neoangiogenesis and survival. Br. J. Cancer 77:1696-1703; 1998.
46. Sivridis, E.; Giatromanolaki, A.; Koukourakis, M. I.; Koukourakis, M. I.; Bicknell, R.; Gatter, K. C.; Harris, A. L. Thymidine phosphorylase expression in normal and hyperplastic endometrium. Clin. Exp. Metastasis (in press).
47. Kitazono, M.; Takebayashi, Y.; Ishitsuka, K.; Takao, S.; Tani, A.; Furukawa, T.; Miyadera, K.; Yamada, Y.; Aikou, T.; Akiyama, S. Prevention of hypoxia-induced apoptosis by the angiogenic factor thymidine phosphorylase. Biochem. Biophys. Res. Commun. 253: 797-803; 1998.
48. Giatromanolaki, A.; Koukourakis, M. I.; Georgoulias, V.; Gatter, K. C.; Harris, A. L.; Fountzilas, G. Angiogenesis vs. response after combined chemo-radiotherapy of squamous cell head and neck cancer. Int. J. Cancer 80:810-817; 1999.
49. Phillips, R. M.; Pearce, J.; Loadman, P. M.; Michael, Bibby, C.; Cooper, P. A.; Swaine, D. J.; Double, J. A. Angioegenesis in the hollow fiber tumor model influences drug delivery to tumor cells: Implications for anticancer drug screening programs. Cancer Res. 58:5263-5266; 1998.
50. Smoluk, G. D.; Fahey, R. C.; Calabro-Jones, P. M.; Aquilera, J. A.; Ward, J. F. Radioprotection of cells in culture by WR2721 and derivatives: Form of the drug responsible for protection. Cancer Res. 48:3641-3647; 1988.
51. Koukourakis, M. I. The use of Ethyol in chemotherapy and radiation therapy. In: Cytoprotection in cancer therapy: Improving the therapeutic index of cancer treatment. Ethyol Investigators Meeting; Los Angeles, CA, May; 1998.
52. Mauceri, H. J.; Hanna, N. N.; Beckett, M. A.; Gorski, D. H.; Staba, M. J.; Stellato, K. A.; Bigelow, K.; Heimann, R.; Gately, S.; Dhanabal, M.; Soff, G. A.; Sukhatune, V. P.; Kufe, D. W.; Weichselboum, R. R. Combined effects of angiostatin and ionizing radiation in antitumor therapy. Nature 394:287-291; 1998.
53. Saito, H.; Tsujitani, S.; Oka, S.; Kondo, A.; Ikeguchi, M.; Maeta, M.; Kaibara, N. The expression of thymidine phosphorylase correlates with angiogenesis and the efficacy of chemotherapy using fluorouracil derivative in advanced gastric carcinoma. Br. J. Cancer 81:484-489; 1999.