Genomic approach to obesity: Understanding a complex syndrome;Approches génomiques de l'obésité: Vers la compréhension d'un syndrome complexe

Annales d'Endocrinologie

Volumn 61, Issue 6 SUPPL., 2000, Pages 50-55

  Froguel, Ph ^a  

^a INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Genetics; Obesity; Treatment

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR; LEPTIN; MELANOCORTIN 4 RECEPTOR; UNCOUPLING PROTEIN;

CHROMOSOME 10; CHROMOSOME 11; CHROMOSOME 2; CHROMOSOME 20; CHROMOSOME 5; ENVIRONMENTAL FACTOR; GENE EXPRESSION REGULATION; GENETIC LINKAGE; GENETIC RISK; GENETIC SCREENING; HUMAN; LIFESTYLE; OBESITY; PSYCHOSOCIAL ENVIRONMENT; REVIEW; SYNDROME DELINEATION;

CHROMOSOME MAPPING; DIET; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LEPTIN; MUTATION; OBESITY; PHENOTYPE; PRO-OPIOMELANOCORTIN; RECEPTORS, ADRENERGIC, BETA-3; RISK FACTORS; SYNDROME;

EID: 0034536718     PISSN: 00034266     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (22)

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5. Genetic variation in the beta 3 adrenergic receptor gene and an increased capacity to gain weight in patients with morbid obesity
6. Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function
7. DNA polymorphism in the uncoupling protein (UCP) gene and human body fat
8. Additive effects of polymorphisms in the uncoupling protein gene and the beta-3 adrenergic receptor gene on gain weight in morbid obesity
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13. Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7
14. An exploratory investigation of genetic linkage with body composition and fatness phenotypes: The Quebec Family Study
15. A polymorphism in the 5′ untranslated region of the human ob gene is associated with low leptin levels
16. Novel polymorphisms in the 5′ region of the LEP gene: Association with leptin levels and response to low-calorie diet in human obesity
17. Functional analysis of the human D2dopamine receptor variants
18. A genome-wide scan for human obesity genes shows evidence for a major susceptibility locus on chromosome 10
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20. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2
21. Genomewide Search for Genes Influencing Percent Body Fat in Pima Indians: Suggestive Linkage at Chromosome 11q21-q22
22. Formes monogéniques d'obésité: De la souris à l'homme