Short-term infection with Helicobacter pylori and 1 week exposure to metronidazole does not enhance gastric mutation frequency in transgenic mice

Journal of Antimicrobial Chemotherapy

Volumn 46, Issue 6, 2000, Pages 987-992

  Touati, Eliette ^a   Hofnung, Maurice ^a   Thiberge, Jean Michel ^b   Michela, Valérie ^a   Labigneb, Agnès ^b   Jenks, Peter J ^c  

^a Programmation Moléculaire et Toxicologie Gé   (France)

^b INSTITUT PASTEUR   (France)

^c ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROIMIDAZOLE; 7 METHOXY 2 NITRONAPHTHO[2,1 B]FURAN; AGAR; AMPHOTERICIN B; ANTIINFECTIVE AGENT; AROMATIC NITRO COMPOUND; BACTERIAL DNA; BACTERIAL ENZYME; BETA GALACTOSIDASE; CARCINOGEN; DNA; HYDROXYLAMINE; IMMUNOGLOBULIN G; METHANOL; METRONIDAZOLE; MUTAGENIC AGENT; NITRO DERIVATIVE; NITROFURAN DERIVATIVE; NITROREDUCTASE; NITROSO DERIVATIVE; OXYGEN; PEPTONE; POLYMYXIN; PYRANOSIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REPRESSOR PROTEIN; TRIMETHOPRIM; TRYPSIN; UNINDEXED DRUG; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; BACTERIAL GENE; BACTERIOPHAGE LAMBDA; BACTERIUM MUTANT; CELL CULTURE; CHRONIC DISEASE; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG ACTIVITY; DRUG EXPOSURE; EPITHELIUM CELL; GENE MUTATION; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; MOUSE; MUTAGENESIS; MUTAGENICITY; MUTATION RATE; NONHUMAN; STOMACH EPITHELIUM; STOMACH INJURY; TRANSGENE; TRANSGENIC MOUSE;

EID: 0034536333     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/46.6.987     Document Type: Article

References (47)

1. Unidentified curved bacilli on gastric epithelium in chronic active gastritis
2. Helicobacter pylori infection and the risk of gastric carcinoma
3. Association between infection with Helicobacter pylori and risk of gastric cancer: Evidence from a prospective study
4. An international association between Helicobacter pylori and risk of gastric cancer
5. Nitroimidazole drugs - Action and resistance mechanisms. I. Mechanisms of action
6. Redox potential and oxygen concentration as factors in the susceptibility of Helicobacter pylori to nitroheterocyclic drugs
7. The influence of microaerophilia and anaerobiosis on metronidazole uptake in Helicobacter pylori
8. Oxygen scavenging NADH oxidase and metronidazole resistance in Helicobacter pylori
9. The complete genome sequence of the gastric pathogen Helicobacter pylori
10. Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase
11. Antitrichomonad action, mutagenicity, and reduction of metronidazole and other nitroimidazoles
12. Targeted disruption of the gene encoding the classical nitroreductase enzyme in Salmonella typhimurium Ames test strains TA1535 and TA1538
13. An in vivo assay using transgenic mice to analyze spontaneous and induced mutations at the nucleic acid level Strategies in
14. Spectra of spontaneous and induced mutations using a Lambda Zap lacl shuttle vector in transgenic mice
15. Transgenic systems for in vivo mutation analysis
16. A standardized mouse model of Helicobacter pylori infection: Introducing the Sydney strain
17. The role of the rdxA gene in the evolution of metronidazole resistance in Helicobacter pylori
18. Immune responses of specific-pathogen-free mice to chronic Helicobacter pylori (strain SS1) infection
19. Genotoxic properties of a nitrofuran, 7-methoxy-2-nitronaph-tho[2,1-b]-furan (R7000), in lacl transgenic mice
20. Treatment protocols for transgenic mutation assays in vitro
21. Induction of mutations in transgenic animal models: BigBlue(TM) and Muta(TM) Mouse
22. Phenotypic and genotypic events in gastric carcinogenesis
23. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer
24. Helicobacter pylori and atrophic gastritis: Importance of the cagA status
25. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection
26. Infection with Helicobacter pylori strains possessing CagA is associated with an increased risk of developing adenocarcinoma of the stomach
27. Helicobacter pylori infection and gastric cancer
28. Human gastric carcinogenesis-a multi-step and multifactorial process. First American Cancer Society Award lecture on cancer epidemiology and prevention
29. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice
30. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii
31. High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL/6 mice
32. Increased prevalence of precancerous changes in relatives of gastric cancer patients: Critical role of H. pylori
33. Interleukin-1 polymorphisms associated with increased risk of gastric cancer
34. Helicobacter pylori infection enhances N-methyl-N-nitrosourea-induced stomach carcinogenesis in the Mongolian gerbil
35. Effect of Helicobacter pylori infection on the N-methyl-N-nitro-N-nitro-soguanidine-induced gastric carcinogenesis in Mongolian gerbills
36. Study design and sample sizes for a lacl transgenic mouse mutation assay
37. Exposure to metronidazole in vivo readily induces resistance in Helicobacter pylori and reduces the efficacy of eradication therapy in mice
38. Evaluation of nitrofurantoin-containing combination therapy to eradicate metronidazole-sensitive and -resistant Helicobacter pylori infections from mice
39. Animal models for gastric Helicobacter immunology and vaccine studies
40. Helicobacter pylori infection induces gastric cancer in Mongolian gerbils
41. Helicobacter pylori-associated gastritis in mice is host and strain specific
42. Analysis of cell damage and proliferation in Helicobacter pylori-infected human gastric mucosa from patients with gastric adenocarcinoma
43. Cell proliferation in Helicobacter pylori associated gastritis and the effect of eradication therapy
44. Helicobacter pylori and gastric carcinogenesis
45. Analysis of p53 gene mutations in Helicobacter pylori-associated gastritis mucosa in endoscopic biopsy specimens
46. Molecular alterations in early gastric carcinomas; no apparent correlation with Helicobacter pylori status