Temporal loss of Nef-epitope CTL recognition following macaque lipopeptide immunization and SIV challenge

Virology

Volumn 278, Issue 2, 2000, Pages 551-561

  Mortara, Lorenzo ^a   Letourneur, Franck ^a   Villefroy, Pascale ^a   Beyer, Christian ^b   Gras Masse, Helene ^c   Guillet, Jean Gérard ^a   Bourgault Villada, Isabelle ^a  

^a Hôpital Cochin ^*  (France)

^b INSERM   (France)

^c UNIV LILLE   (France)

Author keywords

Cytotoxic T lymphocytes; Lipopeptides; Nef protein; Vaccination; Viral escape mutants

Indexed keywords

EPITOPE; GAG PROTEIN; LIPOPEPTIDE; NEF PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ANTIVIRAL ACTIVITY; ARTICLE; CELL INTERACTION; IMMUNE RESPONSE; IMMUNIZATION; MONKEY DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN VARIANT; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE; VACCINATION; VIRUS INFECTION; VIRUS MUTANT; VIRUS MUTATION; VIRUS REPLICATION;

ANIMALIA; MACACA MULATTA; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0034534404     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2000.0671     Document Type: Article

References (43)

1. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells
2. Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
3. Simian immunodeficiency virus as a model for vaccination against HIV: Induction in rhesus macaques of GAG or NEF specific cytotoxic T lymphocytes by lipopeptides
4. Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 tat protein vaccine
5. The acidic region and conserved putative protein kinase C phosphorylation site in Nef are important for SIV replication in rhesus macaques
6. HLA-dependant variations in human immunodeficiency virus Nef protein alter peptide/HLA binding
7. Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein
8. + responses in HIV type 1-infected patients: Comparison with anti-EBV responses and changes during antiretroviral therapy
9. Comparative efficiency of simple lipopeptide constructs for in vivo induction of virus-specific CTL
10. Flanking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes
11. Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef
12. Env-specific CTL predominate in cats protected from feline immunodeficiency virus infection by vaccination
13. + Nef-specific cytotoxic T cells in vaccinated macaques
14. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
15. HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product
16. DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: Immunogenicity in mice
17. Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection: Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load
18. Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection
19. Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells
20. + T cell depletion in simian immunodeficiency virus-infected macaques
21. Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection
22. + lymphocyte responses in the cervix of HIV-1-resistant prostitutes in Nairobi
23. + T cells by primary HIV-1 infection: Potential mechanism of vaccine failure
24. Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants
25. Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys
26. Cytotoxic T lymphocytes (CTL) against a transforming gene product select for transformed cells with point mutations within sequences encoding CTL recognition epitopes
27. HLA and natural history of HIV infection
28. The GAG-specific cytotoxic T lymphocytes in rhesus monkeys infected with the simian immunodeficiency virus of macaques
29. + T-cell help is required for induction of antipeptide multispecific cytotoxic T lymphocytes by a lipopeptidic vaccine in rhesus macaques
30. Selection of virus variants and emergence of virus escape mutants after immunization with epitope vaccine
31. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
32. Human immunodeficiency virus genetic variation can escape cytotoxic T cell recognition
33. Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo
34. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection
35. Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations
36. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi
37. + lymphocytes
38. Analysis of human immunodeficiency virus type 1 nef gene sequences present in vitro
39. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells
40. Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis
41. Molecular and functional analysis of a conserved CTL epitope in HIV-1 p24 recognized from a long-term nonprogressor: Constraints on immune escape associated with targeting a sequence essential for viral replication
42. + cytotoxic T-cell epitopes