Cytokine expression during allergen-induced late nasal responses: IL-4 and IL-5 mRNA is expressed early (at 6 h) predominantly by eosinophils

Clinical and Experimental Allergy

Volumn 30, Issue 12, 2000, Pages 1709-1716

  Nouri Aria, K T ^a   O'Brien, F ^a   Noble, W ^a   Jabcobson, M R ^a   Rajakulasingam, K ^b   Durham, S R ^a,c  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b HOMERTON UNIVERSITY HOSPITAL   (United Kingdom)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Allergen challenge; Allergic rhinitis; Eosinophils; Immunohistochemistry; In situ hybridization; TH2 cytokines

Indexed keywords

ALLERGEN; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA;

ADULT; ALLERGIC RHINITIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; EOSINOPHIL; FEMALE; HUMAN; IMMUNOHISTOLOGY; IN SITU HYBRIDIZATION; MALE; MAST CELL; NOSE MUCOSA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROVOCATION TEST; T LYMPHOCYTE;

ADULT; ALLERGENS; BIOPSY; EOSINOPHILS; FEMALE; HUMANS; IMMUNIZATION; IN SITU HYBRIDIZATION; INTERLEUKIN-4; INTERLEUKIN-5; LEUKOCYTE COUNT; MALE; NASAL MUCOSA; RHINITIS, ALLERGIC, PERENNIAL; RNA, MESSENGER; TIME FACTORS;

EID: 0034533729     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2000.00998.x     Document Type: Article

References (33)

1. Allergic rhinitis
2. Immunohistology of the nasal mucosa in seasonal allergic rhinitis: Increases in activated eosinophils and epithelial mast cells
3. Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: Evidence for the human mast cell as a source of these cytokines
4. Identification of messenger RNA for IL-4 in human eosinophils with granule localization and release of the translated product
5. Expression of mRNA and immunoreactivity for granulocyte/macrophage colony-stimulating factor in activated human eosinophils
6. Expression of epsilon germ-line gene transcripts and mRNA for the epsilon heavy chain of IgE in nasal B cells and the effects of topical corticosteroid
7. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants
8. Kinetics of cell infiltration and cytokine messenger RNA expression after intradermal challenge with allergen and tuberculin in the same atopic individuals
9. High affinity immunoglobulin E receptor (FcεRI) bearing eosinophils, mast cells, macrophages and langerhan's cells in allergen-induced late-phase cutaneous reactions in atopic subjects
10. T lymphocytes and mast cells express messenger RNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis
11. Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and intedeukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects
12. Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation
13. Cytokine generation by eosinophils
14. T cells are the principal source of interleukin-5 mRNA in allergen-induced rhinitis
15. A biopsy method to obtain high quality specimens of nasal mucosa
16. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses
17. Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects
18. Immunohistology of the nasal mucosa following allergen-induced rhinitis. Identification of activated T lymphocytes, eosinophils, and neutrophils
19. IL-4- and IL-5-positive T lymphocytes, eosinophils, and mast cells in allergen-induced late-phase cutaneous reactions in atopic subjects
20. Enhanced expression of high-affinity IgE receptor (Fc epsilon RI) alpha chain in human allergen-induced rhinitis with co-localization to mast cells, macrophages, eosinophils, and dendritic cells
21. + lymphocytes, activated eosinophils, and the magnitude of the allergen-induced late phase cutaneous reaction in man
22. The pattern of human late-phase skin reactions to extracts of aeroallergens
23. Immunohistochemical detection of human basophils in late-phase skin reactions
24. Intracellular localization of interlukin-6 in eosinophils from atopic asthmatics and effects of interferon gamma
25. Indentification of interlukin-2 in human peripheral blood eosinophils
26. Synthesis of type 1 (IFN gamma) and type 2 (IL-4, IL-5, and IL-10) cytokines by human eosinophils
27. Synthesis of cytokines by eosinophils and their regulation
28. Human eosinophils produce biologically active IL-12: Implications for control of T cell responses
29. Pathogenesis allergic rhintis
30. Associations between IL-13 and IL-4 (mRNA and protein), vascular cell adhesion molecule-1 expression, and the infiltration of eosinophils, macrophages, and T cells in allergen-induced late-phase cutaneous reactions in atopic subjects
31. Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia
32. The eosinophilic injury to the mucosa of the airways in the pathogenesis of bronchial asthma
33. Treatment of asthma with drugs modifying the leukotriene pathway