Vascular remodeling and growth factor gene expression in the rat lung during hypoxia

Respiration Physiology

Volumn 111, Issue 2, 1998, Pages

  Pfeifer, Michael ^a   Blumberg, Friedrich C ^a   Wolf, Konrad ^a   Sandner, Peter ^a   Elsner, Dietmar ^a   Riegger, Günther A J ^a   Kurtz, Armin ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Hypoxia, chronic, lung vascular remodeling; Mammals, rat; Mitogens, PDGF, VEGF; Peptides, vasoactive, endothelin; Pulmonary circulation, chronic hypoxia, vascular remodeling

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN 3; GROWTH FACTOR; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR B; VASCULOTROPIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HEMODYNAMICS; HYPOXIA; LUNG BLOOD VESSEL; LUNG CIRCULATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANOXIA; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIN-1; ENDOTHELIN-3; GENE EXPRESSION; GROWTH SUBSTANCES; HYPERTENSION, PULMONARY; LUNG; LYMPHOKINES; MALE; PLATELET-DERIVED GROWTH FACTOR; PULMONARY CIRCULATION; RATS; RATS, WISTAR; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0344431290     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5687(97)00102-3     Document Type: Article

References (31)

1. Bucher M., Sandner P., Wolf K., Kurtz A. Cobalt but not hypoxia stimulates PDGF gene expression in rats. Am. J. Physiol. 271:1996;E451-457.
2. Chen S.J., Vhen Y.F., Meng Q.C., Durand J., DiCarlo V.S., Oparil S. Endothelin-receptor antagonist bosentan prevents and reverses hypoxic pulmonary hypertension in rats. J. Appl. Physiol. 79:1995;2122-2131.
3. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Ann. Biochem. 162:1987;156-159.
4. Crawley D.E., Liu S.F., Barnes S.P., Evans T.W. Endothelin-3 is a potent pulmonary vasodilator in the rat. J. Appl. Physiol. 72:1992;1425-1431.
5. Elton T.S., Oparil S., Taylor G.R., Hicks P.H., Yang R.H., Jin H., Chen Y.F. Normobaric hypoxia stimulates endothelin-1 gene expression in the rat. Am. J. Physiol. 263:1992;R1260-1264.
6. Ferri C., Bellini C., De-Angelis C., De-Siati L., Perrone A., Properzi G., Santucci A. Circulating endothelin-1 concentrations in patients with chronic hypoxia. J. Clin. Pathol. 48:1995;519-524.
7. Firth J.D., Ratcliffe P.J. Organ distribution for the three rat endothelin messenger RNAs and the effects of ischemia on renal gene expression. J. Clin. Invest. 90:1992;1023-1031.
8. Hannink M., Donoghue D.J. Structure and function of platelet-derived growth factor (PDGF) and related proteins. Biochim. Biophys. Acta. 989:1989;1-10.
9. Hassoun P.M., Thappa V., Landman M.J., Fanburg B.L. Endothelin 1: Mitogenic activity on pulmonary artery smooth muscle cells and release from hypoxic endothelial cells. Proc. Soc. Exp. Biol. Med. 199:1992;65-70.
10. Jaffer F.E., Knauss T.C., Poptic E., Abboud H.E. Endothelin stimulates PDGF secretion in cultured human mesangial cells. Kidney Int. 38:1990;1193-1198.
11. Janakidevi K., Fisher M.A., Del Vecchio P.J., Tiruopathi C., Figge J., Malik A.B. Endothelin-1 stimulates DNA synthesis and proliferation of pulmonary artery smooth muscle cells. Am. J. Physiol. 263:1992;C1295-C1301.
12. Katayose D., Ohe M., Yamauchi K., Ogata M., Shirato K., Fujita H., Shibahara S., Takishima T. Increased expression of PDGF A- and B-chain genes in rat lungs with hypoxic pulmonary hypertension. Am. J. Physiol. 264:1993;L100-106.
13. Kourembanas S., Hannan R.L., Faller E.V. Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells. J. Clin. Invest. 86:1990;670-674.
14. Kourembanas S., Marsden P.A., McQuillan L.P., Faller E.V. Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J. Clin. Invest. 88:1991;1054-1057.
15. Li H., Chen S.J., Chen Y.F., Meng Q.C., Durand J., Oparil S., Elton T.S. Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia. J. Appl. Physiol. 77:1994;1451-1459.
16. Meyrick B., Reid L. The effect of continued hypoxia on rat pulmonary arterial circulation: An ultrastructural study. Lab. Invest. 38:1978;188-200.
17. Minchenko A., Bauer T., Salceda S., Caro J. Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo. Lab. Invest. 71:1994;374-379.
18. Morbidelli L., Orlando C., Maggi C.A., Ledda F., Zachi M. Proliferation and migration of endothelial cells is promoted by endothelins via activation of ET-B receptors. Am. J. Physiol. 269:1995;H686-H695.
19. Namiki A., Hirata Y., Ishikawa M., Moroi M., Aikawa J., Machii K. Endothelin-1- and endothelin-3-induced vasorelaxation via common generation of endothelium-derived nitric oxide. Life Sci. 50:1992;677-682.
20. Oparil S., Chen S.J., Meng Q.C., Elton T.S., Yano M., Chen Y.F. Endothelin-A receptor antagonist prevents acute hypoxia-induced pulmonary hypertension in the rat. Am. J. Physiol. 268:1995;L95-100.
21. Peacock A.J., Dawes K.E., Shock A., Gray A.J., Reeves J.T., Laurent G.J. Endothelin-1 and endothelin-3 induce chemotaxis and replication of pulmonary artery fibroblasts. Am. J. Respir. Cell Mol. Biol. 7:1992;492-499.
22. Ratcliffe P.J., Jones R.W., Philips R.E., Nicholls L.G., Bell J.I. Oxygen-dependent modulation of erythropoietin mRNA levels. J. Exp. Med. 172:1991;657-660.
23. Ritthaler T., Göpfert T., Firth J.D., Ratcliffe P.J., Krämer B.K., Kurtz A. Influence of hypoxia on hepatic and renal endothelin expression. Pflüg. Arch. 431:1996;587-593.
24. Rodman D.M., McMurtry I.F., O'Brien R.F. Compartive pharmacology of rat and porcine endothelin in rat aorta and pulmonary artery. Eur. J. Pharmacol. 165:1988;297-300.
25. Sandner P., Gess B., Wolf K., Kurtz A. Divergent regulation of vascular endothelial growth factor and of erythropoetin gene expression. Pflüg. Arch. 431:1996;905-912.
26. Semenza G.L., Agani F., Booth G., Forsythe J., Iyer N., Jiang B.-H., Leung S., Roe R., Wiener C., Yu A. Structural and functional analysis of hypoxia-inducible factor 1. Kidney Int. 51:1997;553-555.
27. Stelzner T.J., O'Brien R.F., Yanagisawa M., Sakurai T., Sato K., Webb S., Zamora M., McMurtry I.F., Fisher J.H. Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension. Am. J. Physiol. 262:1992;L614-L620.
28. Stewart D.J. Endothelin in cardiopulmonary disease: Factor paracrine vs. neurohumoral. Eur. Heart J. 14:1993;48-54.
29. Tso J.H., Sun X.H., Kao T.H., Reece K.H., Wu R. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: Genomic complexity and molecular evolution of the gene. Nucleic Acids Res. 13:1985;2485-2492.
30. Tuder R.M., Flook B.E., Voelkel N.F. Increased gene expression for VEGF and the VEGF receptors KDR8Flk and Flt in lungs exposed to acute and chronic hypoxia. J. Clin. Invest. 95:1995;1798-1807.
31. Wagner O.F., Christ G., Wojta J., Vierhappner H., Parzer S., Nowotny P.J., Schneider B., Waldhausl W., Binder B.R. Polar secretion of endothelin-1 by cultured endothelial cells. J. Biol. Chem. 267:1992;16066-16068.