Significant association between a silent polymorphism in the neuromedin B gene and body weight in german children and adolescents

Acta Diabetologica

Volumn 37, Issue 2, 2000, Pages 93-101

  Oeffner, F ^a   Bornholdt, D ^a   Ziegler, A ^a   Hinney, A ^a   Gorg T ^a   Gerber, G ^a   Goldschmidt, H P ^b   Siegfried, W ^c   Wright, A ^d   Hebebrand, J ^a   Grzeschik, K H ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b Spessart Klinik   (Germany)

^c Obesity Treatment Center Insula   (Germany)

^d WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Association; Bardet Biedl syndrome; Neuromedin B; Polymorphism; Weight regulation

Indexed keywords

NEUROMEDIN B;

ADOLESCENT; ARTICLE; BARDET BIEDL SYNDROME; BODY WEIGHT; CHILD; CHROMOSOME 15Q; CHROMOSOME MAP; CLINICAL ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FOOD INTAKE; GENE MUTATION; GENE SEQUENCE; GENE STRUCTURE; GERMANY; HUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; STOP CODON;

ADOLESCENT; ADULT; ALLELES; AMINO ACID SEQUENCE; BARDET-BIEDL SYNDROME; BASE SEQUENCE; BODY WEIGHT; CASE-CONTROL STUDIES; EXONS; GENE FREQUENCY; GENE SILENCING; GENOME; GENOTYPE; HUMANS; MOLECULAR SEQUENCE DATA; NEUROKININ B; OBESITY; POLYMORPHISM, GENETIC; THINNESS;

EID: 0034529892     PISSN: 09405429     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005920070026     Document Type: Article

References (40)

1. Ein Geschwisterpaar mit adiposo-genitaler Dystrophie
2. Bardet-Biedl syndrome: A molecular and phenotypic study of 18 families
3. Linkage of Bardet-Biedl syndrome to chromosome 16q and evidence for non-allelic genetic heterogeneity
4. Bardet-Biedl syndrome is linked to DNA markers on chromosome 11q and is genetically heterogeneous
5. Identification of a Bardet-Biedl syndrome locus on chromosome 3 and evaluation of an efficent approach to homozygosity mapping
6. Use of a DNA pooling strategy to identify a human obesity syndrome locus on chromosome 15
7. A fifth locus for Bardet-Biedl syndrome maps to chromosome 2q31
8. Bardet-Biedl and Laurence-Moon syndromes in a mixed Arab population
9. Investigations cliniques et genetiques sur le syndrome de Bardet-Biedl en Suisse
10. Linkage mapping in 29 Bardet-Biedl syndrome families confirms loci in chromosomal regions 11q13, 15q22.3-q23 and 16q21
11. A genome-wide scan for human obesity reveals a major susceptibility locus on chromosome 10
12. Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes
13. Bombesin-like peptides in rat brain: Quantitation and biochemical characterization
14. Gastrin-releasing peptide (GRP) is not mammalian bombesin
15. Phyllomedusa skin: A huge factory and store-house of a variety of active peptides
16. Peptide growth factors and their receptors II
17. PCR analysis of somatic cell hybrids localizes the neuromedin B receptor (hNMBr) gene to chromosome 6q21-qter
18. Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity
19. Evidence for autocrine actions of neuromedin B and gastrin-releasing peptide in non-small cell lung cancer
20. The presence, characterisation and synthesis of neuromedin B in the human pituitary gland
21. Role of neuromedin B in control of the release of thyrotropin in hypothyroid and hyperthyroid rats
22. Pituitary neuromedin B content in experimental fasting and diabetes mellitus and correlation with thyrotropin secretion
23. Role of neuromedins in the regulation of adrenocortical function
24. Bombesin and neuromedin B stimulate the activation of p42(mapk) and p74(raf-1) via a protein kinase C-independent pathway in Rat-1 cells
25. Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B
26. Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides
27. Distribution of two distinct messenger ribonucleic acids encoding gastrin-releasing peptide in rat brain
28. Brief, meal-contingent infusions of gastrin-releasing peptide 1-27 and neuromedin B-10 inhibit spontaneous feeding in rats
29. Mammalian bombesin-like peptides extend the intermeal interval in freely feeding rats
30. Caudal hindbrain neuromedin B-preferring receptors participate in the control of food intake
31. Beta 3-adrenergic-receptor allele distributions in children, adolescents and young adults with obesity, underweight or mmrexia nervosa
32. Use of percentiles for the body mass index in anorexia nervosa: Diagnostic, epidemiological and therapeutic considerations
33. Analysis of the VNTR locus DIS80 by PCR followed by high-resolution PAGE
34. Point mutations in human GLI3 cause Greig syndrome
35. Human transcription factor SLUG: Mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region
36. Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23
37. Genomic structure and chromosomal localization of the mouse gene punc
38. The cloning and developmental expression of unconventional myosin IXA (MYO9A), a gene in the Bardet-Biedl syndrome (BBS4) region at chromosome 15q22-q23