Brief, meal-contingent infusions of gastrin-releasing peptide1-27 and neuromedin B-10 inhibit spontaneous feeding in rats

Physiology and Behavior

Volumn 60, Issue 6, 1996, Pages 1501-1504

  Rushing, Paul A ^a   Gibbs, James ^a   Geary, Nori ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Bombesin; Food intake; Ingestion; Intermeal interval; Satiety ratio; Vena cava

Indexed keywords

BOMBESIN; GASTRIN RELEASING PEPTIDE; NEUROMEDIN B;

ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; FEEDING BEHAVIOR; FOOD INTAKE; INGESTION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SATIETY;

EID: 0030561215     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(96)00324-1     Document Type: Article

References (22)

1. Bado A., Lewin M.J.M., Dubrasquet M. Effects of bombesin on food intake and gastric acid secretion in cats. Am. J. Physiol. 256:1989;R181-R186.
2. Denbow D.M. Centrally and peripherally administered bombesin decreases food intake in turkeys. Peptides. 10:1989;275-279.
3. Ersparmer V. Discovery, isolation, and characterization of bombesin-like peptides. Ann. N. Y. Acad. Sci. 547:1988;3-9.
4. Ersparmer V., Ersparmer G.F., Inselvini M. Some pharmacological actions of alytesin and bombesin. J. Pharm. Pharmacol. 22:1970;875-876.
5. Flynn F.W. Fourth ventricle bombesin injection suppresses ingestive behavior in rats. Am. J. Physiol. 256:1989;R590-R596.
6. Gibbs J., Fauser D.J., Rowe E.A., Rolls B.J., Rolls E.T., Maddison S.P. Bombesin supresses feeding in rats. Nature. 282:1979;208-210.
7. Gibbs, J.; Geary, N.; Smith, G.P. Peptide signals for satiety. In: Moody, T.W., ed. Growth factors, peptides, and receptors. New York: Plenum Press; 1993:435-443.
8. Gibbs J., Kulkosky P.J., Smith G.P. Effects of peripheral and central bombesin on feeding behavior of rats. Peptides. 2((suppl. 2)):1981;179-181.
9. Gibbs, J.; Smith, G.P. Effects of brain-gut peptides on satiety. In: Björntorp, P.; Brodoff, B., eds. Obesity. Philadelphia: J.B. Lippincott Co.; 1992:399-410.
10. Himick B.A., Peter R.E. Bombesin acts to suppress feeding behavior and alter serum growth hormone in goldfish. Physiol. Behav. 55:1994;65-72.
11. Kaufman S. Chronic, nonocclusive, and maintenance-free central venous cannula in the rat. Am. J. Physiol. 239:1980;R123-R125.
12. Ladenheim E.E., Wirth K.E., Moran T.H. Receptor subtype modulation of feeding suppression by bombesin-like peptides. Pharmacol. Biochem. Behav. 54:1996;705-711.
13. Ladenheim E.E., Ritter R.C. Low-dose fourth ventricular bombesin selectively suppresses food intake. Am. J. Physiol. 255:1988;R988-R992.
14. Lieverse R.J., Jansen J.B.M.J., van de Zwan A., Samson L., Masclee A.A.M., Rovati L.C., Lamers C.B.H.W. Bombesin reduces food intake in lean man by a cholecystokinin-independent mechanism. J. Clin. Endocrinol. Metab. 76:1993;1495-1498.
15. Muurahainen N.E., Kissileff H.R., Pi-Sunyer F.X. Intravenous infusion of bombesin reduces food intake in humans. Am. J. Physiol. 264:1993;R350-R354.
16. Rushing P.A., Gibbs J., Geary N. Vena caval bombesin infusion decreases spontaneous meal size in undisturbed rats. Physiol. Behav. 59:1996;307-310.
17. Stratford T.R., Gibbs J., Smith G.P. Microstructural analysis of licking behavior following peripheral administration of bombesin or gastrin-releasing peptide. Peptides. 16:1995;903-909.
18. 1-27 reproduces the satiating and microstructural effects of bombesin. Peptides. 17:1996;107-110.
19. Stuckey J.A., Gibbs J. Lateral hypothalamic injection of bombesin decreases food intake in rats. Brain Res. Bull. 8:1982;617-621.
20. Von Schrenck T., Wang L.H., Coy D.H., Villanueva M.L., Mantey S., Jensen R.T. Potent bombesin receptor antagonists distinguish receptor subtypes. Am. J. Physiol. 259:1990;G468-G473.
21. Woods S.C., Stein L.J., Figlewicz D.P., Porte D. Jr. Bombesin stimulates insulin secretion and reduces food intake in the baboon. Peptides. 4:1983;687-691.
22. Stein L.J., Woods S.C. Gastrin releasing peptide reduces meal size in rats. Peptides. 3:1982;833-835.