In vivo modulation of human β-globin gene switching

Trends in Cardiovascular Medicine

Volumn 10, Issue 1, 2000, Pages 15-19

  Tanimoto, Keiji ^a   Engel, James Douglas ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN;

CHROMOSOME INVERSION; ERYTHROPOIESIS; GENE ACTIVATION; GENE CONTROL; GENE LOCUS; GENE ORDER; GENE SWITCHING; GENETIC TRANSCRIPTION; GLOBIN GENE; HUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW;

ANIMALS; BETA-GLOBULINS; CHROMOSOMES, ARTIFICIAL, YEAST; GENES, SWITCH; GENETIC TECHNIQUES; HUMANS; LOCUS CONTROL REGION; MICE; MICE, TRANSGENIC; RECOMBINATION, GENETIC; TRANSCRIPTION, GENETIC; TRANSGENES;

EID: 0034529044     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(00)00035-9     Document Type: Review

References (38)

1. The β-Globin LCR controls expression levels but does not prevent heterocellular position effects
2. Looping versus linking; toward a model for long-distance gene activation
3. Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4
4. Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription
5. Developmental regulation of beta-globin gene switching
6. A 5′ element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effects in Drosophila
7. The effect of distance on long-range chromatin interactions
8. The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus
9. Evidence for a locus activation region; the formation of developmentally stable hypersensitive sites in globin-expressing hybrids
10. Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes
11. Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human β-globin locus in transgenic mice
12. Physical mapping of yeast artificial chromosomes containing sequences from the human beta-globin gene region
13. The regulation of human globin gene switching
14. Position-independent, high-level expression of the human beta-globin gene in transgenic mice
15. Importance of globin gene order for correct developmental expression
16. Locus control regions of mammalian beta-globin gene clusters; combining phylogenetic analyses and experimental results to gain functional insights
17. Do LCRs open chromatin domains?
18. Analysis of mice containing a targeted deletion of beta-globin locus control region 5′ hypersensitive site 3
19. Individual LCR HS sites cooperate to generate an open chromatin domain spanning the human β-globin locus
20. Hypersensitive site 5 of the human beta locus control region functions as a chromatin insulator
21. Regulation of beta-globin gene expression; straightening out the locus
22. Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletion
23. Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human genes
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25. Role of gene order in developmental control of human gamma- and beta-globin gene expression
26. Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators
27. The human beta globin locus introduced by YAC transfer exhibits a specific and reproducible pattern of developmental regulation in transgenic mice
28. An insulator element and condensed chromatin region separate the chicken beta-globin locus from an independently regulated erythroid-specific folate receptor gene
29. Chromosome engineering in mice
30. Cre-stimulated recombination at loxP-containing DNA sequences placed into the mammalian genome
31. Developmental regulation of human gamma- and beta-globin genes in the absence of the locus control region
32. Putting boundaries on silence
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34. The 'beta-like globin' gene domain in human erythroid cells
35. Transcription complex stability and chromatin dynamics in vivo
36. A 5′ beta-globin matrix-attachment region and the polyoma enhancer together confer position-independent transcription