Labeling and distribution of linear peptides identified using in vivo phage display selection for tumors

Nuclear Medicine and Biology

Volumn 27, Issue 8, 2000, Pages 815-825

  Kennel, Stephen J ^a,b   Mirzadeh, Saed ^a   Hurst, Gregory B ^b   Foote, Linda J ^a   Lankford, Trish K ^a   Glowienka, Kirsten A ^a   Chappell, Lara L ^c   Kelso, Julie R ^a   Davern, Sandra M ^a   Safavy, Ahmad ^d   Brechbiel, Martin W ^c  

^a Life Sciences Division   (United States)

^b OAK RIDGE NATIONAL LABORATORY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d The University of Alabama at Birmingham   (United States)

Author keywords

213Bi; Bifunctional DTPA ligands; Distribution; Peptides; Phage display; Radioiodination; Tumors

Indexed keywords

BISMUTH 213; COMPLEMENTARY DNA; HYDROXYLAMINE; IODINE 125; IODOBENZOIC ACID DERIVATIVE; ISOTHIOCYANIC ACID DERIVATIVE; PENTETIC ACID; PEPTIDE DERIVATIVE; PEPTIDE LIBRARY; TYROSINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHELATION; CONJUGATION; DEHALOGENATION; DNA SEQUENCE; DRUG DELIVERY SYSTEM; FEMALE; ISOTOPE LABELING; MASS SPECTROMETRY; MOUSE; NONHUMAN; PHAGE DISPLAY; PROTEIN BINDING; RADIOIMMUNOTHERAPY; RAT; SCID MOUSE; TRACHEA TUMOR;

AMINO ACID SEQUENCE; ANIMALS; BACTERIOPHAGE M13; BINDING, COMPETITIVE; BISMUTH; CHELATING AGENTS; CONSENSUS SEQUENCE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HYDROXYLAMINES; IODINE RADIOISOTOPES; ISOTOPE LABELING; MICE; MICE, SCID; MOLECULAR SEQUENCE DATA; NEOPLASMS; PEPTIDE LIBRARY; PEPTIDES; RADIOIMMUNOTHERAPY; RADIOISOTOPES; TISSUE DISTRIBUTION;

EID: 0034528132     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(00)00149-9     Document Type: Article

References (46)

1. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
2. 213Bi
3. 90Y radioimmunotherapy
4. Synthesis of C-functionized transcyclohexyldiethyleneuriaminepentaacetic acids for labeling of monoclonal antibodies with the bismuth-212 α particle emitter
5. Vascular endothelial growth factor as a marker of tumor endothelium
6. Up-regulation of endoglin on vascular endothelial cells in human solid tumors: Implications for diagnosis and therapy
7. 213Bi: The role of TNF-α in the development of pulmonary fibrosis
8. Pre-clinical comparison of [DTPAO] octreotide, [DTPAO, Tyr3] octreotide and [DOTAO, Tyr3] octreotide as carriers for somatostatin receptor-targeted scintigraphy and radionuclide therapy
9. Vasculature as a target for tumor therapy
10. Expression of somatostatin receptors in peritumoral veins of human tumors
11. Indium-111-diethylenetriaminepentaacetic acid-octreotide is delivered in vivo to pancreatic tumor cell, renal, and hepatocyte lysosomes
12. Enhanced binding and inertness to dehalogenation of melanotropic peptides labeled using N-succinimidyl 3-iodobenzoate
13. In vivo kinetics of radiolabeled monoclonal anti-CEA antibodies in animal models
14. Antibody phage display technology and its applications
15. 2NH) bond isosteres
16. Localization of small-cell lung cancer xenografts with Iodine-125-, Indium-111-, and Rhenium-188-somatostatin analogs
17. Monoclonal antibody targeting of liposomes to mouse lung in vivo
18. 213Bi
19. 213Bi. An alpha particle emitter
20. 213Bi
21. CD44 expression on murine tissues
22. Rat monoclonal antibody distribution in mice. An epitope inside the vascular space mediates very efficient localization
23. Identification of receptor ligands with phage display peptide libraries
24. A new route to radioiodinated N-succinimydl 3- and 4-iodobenzoate, two reagents for radioiodinations of proteins
25. Evaluation of laminin peptide fragments labeled with indium-111 for the potential imaging of malignant tumors
26. Tight-binding inhibitory sequences against pp60 (c-src) identified using a random 15-amino-acid peptide library
27. Alpha V integrins as receptors for tumor targeting by circulating ligands
28. Organ targeting in vivo using phage display peptide libraries
29. Membrane dipeptidase is the receptor for a lung-targeting peptide identified by in vivo phage display
30. Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display
31. Tumor localization of a radiolabeled bombesin analogue in mice bearing human ovarian tumors induced to express the gastrin-releasing peptide receptor by an adenoviral vector
32. Adenoviral-mediated delivery of gastrin-releasing peptide receptor results in specific tumor localization of a bombesin analogue in vivo
33. Improved in vivo stability and tumor targeting of bismuth-labeled antibody
34. Technetium-99m labeled epidermal growth factor-tumor imaging in mice
35. Further studies on the protein conjugation of hydroxamic acid bifunctional chelating agents: Group-specific conjugation at two different loci
36. Searching for peptides ligands with an epitope library
37. Libraries of peptides and proteins displayed on filamentous phage
38. Inhibition of carcinogen-altered rat tracheal epithelial cell proliferation of normal epithelial cells in vivo
39. Differentiation of normal and cultured preneoplastic epithelial cells in rats: Importance of epithelial mesenchymal interactions
40. Method for radioiodination of proteins using N-succinimidyl 3-hydroxy-4-iodobenzoate
41. Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library
42. Increased binding affinity and valence of recombinant antibody fragments lead to improved targeting of tumoral angiogenesis
43. Improved resolution and very high sensitivity in MALDI-TOF of matrix surfaces made by fast evaporation
44. Synthesis and characterization of multiply-tyrosinated, multiply-iodinated somatostatin analogs
45. Tumor localization of anti-CEA single-chain Fvs: Improved targeting by non-covalent dimers
46. 2 fragments with the α-particle-emitting nuclide astatine-211: Preservation of immunoreactivity and in vivo localization capacity