Inhibition of COX-2 and induction of apoptosis: Two determinants of nonsteroidal anti-inflammatory drugs' chemopreventive efficacies in mouse lung tumorigenesis

Experimental Lung Research

Volumn 26, Issue 8, 2000, Pages 731-742

  Yao, R ^a   Rioux, N ^a   Castonguay, A ^a   You, M ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Chemoprevention; COXs; K ras mutation; Mouse lung tumor; NNK; NSAIDs

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; ACETYLSALICYLIC ACID; CYCLIN B; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; FAS LIGAND; MYOSIN LIGHT CHAIN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN BAD; PROTEIN P57;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; CANCER INHIBITION; CANCER PREVENTION; CHEMOPROPHYLAXIS; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; LUNG CANCER; LUNG CARCINOGENESIS; MOUSE; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOMA; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; ASPIRIN; CHEMOPREVENTION; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DNA, NEOPLASM; ENZYME INHIBITORS; FEMALE; GENES, RAS; IMMUNOENZYME TECHNIQUES; ISOENZYMES; LUNG NEOPLASMS; MEMBRANE PROTEINS; MICE; MICE, INBRED A; MUTATION; NITROBENZENES; NITROSAMINES; POLYMERASE CHAIN REACTION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; SULFONAMIDES;

EID: 0034525705     PISSN: 01902148     EISSN: None     Source Type: Journal    
DOI: 10.1080/01902140150216783     Document Type: Conference Paper

References (36)

1. Mechanism of action of antiinflammatory drugs
2. Colorectal cancer and nonsteroidal anti-inflammatory drugs
3. Aspirin use and lung, colon, and breast cancer incidence in a prospective study
4. Antitumoral activity of indomethacin on experimental esophageal tumors
5. Effect of various prostaglandin synthesis inhibitors on pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxypropyl)amine
6. Effect of the prostaglandin synthetase inhibitor indomethacin on 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats fed different levels of fat
7. Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate
8. Inhibitory effects of non-steroidal anti-inflammatory drugs, piroxicam and indomethacin, on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male ACI/N rats
9. Modulation of methylcholanthrene-induced carcinogenesis in the uterine cervix of mouse by indomethacin
10. Effects of NSAIDs on NNK-induced pulmonary and gastric tumorigenesis in A/J mice
11. Effects of sulindac and oltipraz on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung
12. Chemopreventive efficacies of aspirin and sulindac against lung tumorigenesis in A/J mice
13. Prevention of NNK-induced lung tumorigenesis in A/J mice by acetylsalicylic acid and NS-398
14. COX-1 and COX-2 tissue expression: Implications and predictions
15. Distribution of COX-1 and COX-2 in normal and inflamed tissues
16. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer
17. High cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) contents in mouse lung tumors
18. Cyclooxygenase-2 expression is abundant in alveolar type II cells in lung cancer-sensitive mouse strains and in premalignant lesions
19. Δ716 knockout mice by inhibition of cyclooxygenase-2 (Cox-2)
20. Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: Effects on cell cycle and apoptosis
21. Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by prostaglandin-independent pathway
22. Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis
23. Activation of the K-ras protooncogene in spontaneously occurring and chemically-induced lung tumors of the strain A mouse
24. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase
25. Molecular analysis of spontaneous mutations at the qpt locus in Chinese hamster ovary (AS52) cells
26. Inhibition of cyclooxygenase: A novel approach to cancer prevention
27. Chemoprevention of carcincogenesis by sulindac, a nonsteroidal anti-inflammatory agent
28. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase-2
29. Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas
30. 1 delay in cells overexpressing prostaglandin endoperoxide synthase-2
31. Molecular executors of cell death - Differential intrarenal expression of Fas ligand, Fas, granzyme B, and perforin during acute and/or chronic rejection of human renal allografts
32. Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemia cells undergoing apoptosis
33. KIP2 gene mutation in Beckwith-Wiedemann syndrome
34. KIP2 requires binding to proliferating cell nuclear antigen
35. In vitro binding of free cdc2 and raf kinase to membrane vesicles: A possible new regulatory mechanism for cdc2 kinase activation in Xenopus oocyte
36. Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis