Therapeutic ratio of inhaled corticosteroids in adult asthma: A dose-range comparison between fluticasone propionate and budesonide, measuring their effect on bronchial hyperresponsiveness and adrenal cortex function

American Journal of Respiratory and Critical Care Medicine

Volumn 162, Issue 6, 2000, Pages 2053-2057

  Nielsen, Lars P ^a,b   Dahl, Ronald ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; FLUTICASONE PROPIONATE; HYDROCORTISONE; METHACHOLINE; OSTEOCALCIN;

ADRENAL CORTEX FUNCTION; ADULT; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DOSE CALCULATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; EOSINOPHIL; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; HYDROCORTISONE URINE LEVEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL;

EID: 0034524703     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.162.6.9912072     Document Type: Article

References (36)

1. Inhaled glucocorticoids for asthma
2. Bioequivalent doses of budesonide and prednisone in moderate and severe asthma
3. Side effects of inhaled corticosteroids
4. Measuring efficacy and safety of different inhaled corticosteroid preparations
5. Establishing a therapeutic index for the inhaled corticosteroids: I. Pharmacokinetic/pharmacodynamic comparison of the inhaled corticosteroids
6. Clinical relevance of inhaled corticosteroids and HPA axis suppression
7. National Asthma Education Program. Expert Panel Report. Guidelines for the diagnosis and management of asthma
8. International Consensus Report on Diagnosis and Management of Asthma
9. Methacholine bronchial challenge using a dosimeter with controlled tidal breathing
10. Airway responsiveness: Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society
11. Statistical method in biological assay: The biomathematics of disease
12. Bronchial responsiveness to distilled water and methacholine and its relationship to inflammation and remodeling of the airways in asthma
13. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma
14. Bronchial biopsies in asthma: An ultrastructural, quantitative study and correlation with hyperreactivity
15. Airway responsiveness to histamine and methacholine: Relationship to minimum treatment to control symptoms of asthma
16. Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in nonsteroid-dependent asthmatics
17. The effect of inhaled corticosteroids on the maximal degree of airway narrowing to methacholine in asthmatic subjects
18. Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment: The AMPUL Study Group
19. Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma
20. Dosage and time effects of inhaled budesonide on bronchial hyperreactivity
21. Effects of fluticasone propionate on methacholine dose-response curves in nonsmoking atopic asthmatics
22. Long-term effects of budesonide on airway responsiveness and clinical asthma severity in inhaled steroid-dependent asthmatics
23. Dose-related response to inhaled fluticasone propionate in patients with methacholine-induced bronchial hyperresponsiveness: A double-blind, placebo-controlled study
24. Clinical experience with fluticasone propionate in asthma: A meta-analysis of efficacy and systemic activity compared with budesonide and beclomethasone dipropionate at half the microgram dose or less
25. Comparison of fluticasone propionate and beclomethasone dipropionate on direct and indirect measurements of bronchial hyperresponsiveness in patients with stable asthma
26. High-dose inhaled steroids in the management of asthma: A comparison of the effects of budesonide and beclomethasone dipropionate on pulmonary function, symptoms, bronchial responsiveness and the adrenal function
27. Assessment of the relative systemic potency of inhaled fluticasone and budesonide
28. Comparative adrenal suppression with inhaled budesonide and fluticasone propionate in adult asthmatic patients
29. Adrenal suppression with chronic dosing of fluticasone propionate compared with budesonide in adult asthmatic patients
30. Effects of budesonide and fluticasone on 24-hour plasma cortisol: A dose-response study
31. A dose-response study comparing suppression of plasma cortisol induced by fluticasone propionate from Diskhaler and budesonide from Turbuhaler
32. A comparison of the systemic bioactivity of inhaled budesonide and fluticasone propionate in normal subjects
33. An assessment of the systemic effects of single and repeated doses of inhaled fluticasone propionate and inhaled budesonide in healthy volunteers
34. High dose fluticasone propionate, 1 mg daily, versus fluticasone propionate, 2 mg daily, or budesonide, 1.6 mg daily, in patients with chronic severe asthma
35. A blinded comparison of fluticasone propionate with budesonide via powder devices in adult patients with moderate-to-severe asthma: A clinical evaluation