A blinded comparison of fluticasone propionate with budesonide via powder devices in adult patients with moderate-to-severe asthma: a clinical evaluation

Mediators of Inflammation

Volumn 5, Issue 5, 1996, Pages 382-389

  Ringdal, N ^a   Swinburn, P ^b   Backman, R ^c   Plaschke, P ^d   Sips, A P ^e   Kjaersgaard, P ^f   Bratten, G ^f   Harris, T A J ^g  

^a Molde County Hospital   (Norway)

^b Mercy Specialist Centre   (New Zealand)

^c Meltola Hospital   (Finland)

^d SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^e The Polikliniek Kanalweg ^*  (Netherlands)

^f GLAXOSMITHKLINE   (United States)

^g GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Asthma; Budesonide; Double blind comparison; Fluticasone propionate

Indexed keywords

ANTIASTHMATIC AGENT; BUDESONIDE; FLUTICASONE PROPIONATE; SALBUTAMOL;

ADULT; AGED; ARTICLE; ASTHMA; BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MALE; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0029904558     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/S0962935196000555     Document Type: Article

References (17)

1. National Heart, Lung and Blood Institute. International consensus report on diagnosis and treatment of asthma. Eur Respir J 1992; 5: 601–641.
2. British Thoracic Society. Guidelines for management of asthma. Thorax 1993; 48(suppl): S1–S24.
3. Levy ML, Stevenson IC on behalf of a UK study group. A comparison of the efficacy of inhaled fluticasone propionate 2 mg daily and a reducing course of oral prednisolone in the treatment of acute exacerbations of asthma. American Thoracic Society, Seattle 1995; A276.
4. Geddes D. Inhaled corticosteroids: benefits and risks. Thorax 1992; 47: 404–406.
5. Boe J, Skoogh BE. Is long-term treatment with inhaled steroids hazardous? Eur Respir J 1992; 5: 1037–1039.
6. Brown PH, Blundell G, Greening AP, Crompton GK. Hypothalamo- pituitary-adrenal axis suppression in asthmatics inhaling high dose corticosteroids. Respir Med 1991; 85: 501–510.
7. Phillips GH. Structure-activity relationships of topically active steroids: the selection of fluticasone propionate. Respir Med 1990; 84(suppl A): 19-23.
8. Harding SM. The human pharmacology of fluticasone propionate. Respir Med 1990; 84 (suppl A): 25–29.
9. Umland SP, Nahrebna DK, Rasac S, et al. Effects of mometasone furoate and other glucocorticoids on cytokine production from cultured peripheral blood CD4+ T cells. J Allergy Clin Immunol 1996; 97: A423.
10. Kita H, Hagen JB, Gleich GJ. Fluticasone propionate is the most potent glucocorticoid in the induction of apoptosis of eosinophils. In: Acute and Chronic Inflammation in the Respiratory Tract. International Respiratory Forum. Colwood Publishing, 1995.
11. Schroeder JT, Stellato C, Lichtenstein LM, Bickel CA, Schleimer RP. Regulation of human basophil histamine release and IL–4 secretion by glucocorticoids. In: Acute and Chronic Inflammation in the Respiratory Tract. International Respiratory Forum. Colwood Publishing, 1995.
12. Fabbri L, Burge PS, Croonenborgh L, et al. Comparison of fluticasone propionate with beclomethasone dipropionate in moderate-to-severe asthma treated for one year. Thorax 1993; 48: 817–823.
13. Ayres JG, Bateman ED, Lundbäck B, et al. High dose fluticasone propionate, 1 mg daily, versus fluticasone propionate, 2 mg daily, or budesonide, 1.6 mg daily, in patients with chronic severe asthma. Eur Respir J 1995; 8: 579–586.
14. Leblanc P, Mink S, Keistinen T, et al. A comparison of fluticasone propionate 200 pg/day with beclomethasone dipropionate 400 pg/day in adult asthma. Allergy 1994; 49: 380–385.
15. 1) administered by pressurized inhaler. Respir Med 1993; 87: 609–620.
16. Langdon CG, Casey LJ, UK study group. Fluticasone propionate and budesonide in adult asthmatics: a comparison using dry-powder inhaler devices. Br J Clin Res 1994; 5: 85–99.
17. Langdon CG, Thompson J, on behalf of a UK study group. A multicentre study to compare the efficacy and safety of inhaled fluticasone propionate and budesonide via metered-dose inhalers in adults with mild-to-moderate asthma. Br J Clin Res 1994; 5: 73–84.