Assessment of the relative systemic potency of inhaled fluticasone and budesonide

European Respiratory Journal

Volumn 9, Issue 7, 1996, Pages 1427-1432

  Boorsma, M ^a   Andersson, N ^b   Larsson, P ^b   Ullman, A ^b  

^a Astra Pharmaceutica BV   (Netherlands)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

budesonide; cortical suppressive effect; fluticasone propionate; relative systemic potency

Indexed keywords

BUDESONIDE; FLUTICASONE; HYDROCORTISONE; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DRUG POTENCY; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; INHALATIONAL DRUG ADMINISTRATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VOLUNTEER;

ADMINISTRATION, INHALATION; ADMINISTRATION, TOPICAL; ADULT; AEROSOLS; ANDROSTADIENES; ANTI-INFLAMMATORY AGENTS; BUDESONIDE; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROCORTISONE; MALE; NEBULIZERS AND VAPORIZERS; PREGNENEDIONES; RADIOIMMUNOASSAY;

EID: 0030037163     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.96.09071427     Document Type: Article

References (30)

1. Woodhead M (ed). Guidelines on the management of asthma. Thorax 1993; 48 (Suppl): S1-S24.
2. Barnes PJ. Drug therapy: inhaled glucocorticoids for asthma. N Engl J Med 1995; 332: 868-875.
3. 2agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma, N Engl J Med 1991; 325: 388-392.
4. Agertoft L, Pedersen S. Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children. Respir Med 1994; 88: 373-381.
5. Geddes DM. Inhaled corticosteroids: benefits and risks. Thorax 1992; 47: 404-407.
6. Russell G. Inhaled corticosteroid therapy in children: an assessment of the potential for side effects. Thorax 1994; 49: 1184-1188.
7. Harding SM. The human pharmacology of fluticasone propionate. Respir Med 1990; 80 (Suppl. A): 25-29.
8. Langdon CG, Thompson J. A multicentre study to compare the efficacy and safety of inhaled fluticasone propionate and budesonide via metered-dose inhalers in adults with mild-to-moderate asthma. Br J Clin Res 1994; 5: 73-84.
9. Langdon CG, Capsey LJ. Fluticasone propionate and budesonide in adult asthmatics: a comparison using drypowder inhaler devices. Br J Clin Res 1994; 5: 85-99.
10. Barnes NC, Marone G, Di Maria GU, Visser S, Utama I, Payne SL. A comparison of fluticasone propionate, I mg daily, with beclomethasone dipropionate, 2 mg daily in the treatment of severe asthma. Eur Respir J 1993; 6: 877-885.
11. Ayres JG, Bateman ED, Lundbäck B, Harris TAJ. High dose fluticasone propionate, 1 mg daily, versus fluticasone propionate, 2 mg daily, or budesonide, 1.6 mg daily, in patients with chronic severe asthma. Eur Respir J 1995; 8: 579-586.
12. English AF, Neate MS, Quint DJ, Sareen M. Biological activities of some corticosteroids used in asthma. Am J Respir Crit Care Med 1994; 149: A212.
13. Andersson N, Klint S, Randwall G, Wirén JE. Equipotency of budesonide and fluticasone propionate in the vaso-constriction assay. Am J Respir Crit Care Med 1994; 149: A467.
14. Dahl R, Lundbäck B, Malo IL, et al A dose-ranging study of fluticasone propionate in adult patients with moderate asthma. Chest 1993; 104: 1352-1358.
15. Fabbri L, Burge PS, Croonenborgh L, et al. Comparison of fluticasone propionate with beclomethasone dipropionate in moderate to severe asthma treated for one year. Thorax 1993; 48: 817-823.
16. Grahnén A, Eckernäs SA, Brundin RM, Ling-Andersson A. An assessment of the systemic activity of single doses of inhaled fluticasone propionate in healthy volunteers. Br J Clin Pharmacol 1994; 38: 521-525.
17. Grove A, Allam C, McFarlane LC, McPhate G, Jackson CM, Lipworth BJ. A comparison of the systemic bioactivity of inhaled budesonide and fluticasone in normal subjects. Br J Clin Pharmacol 1994; 38: 527-532.
18. Clark DJ, Grove A, Cargill RI, Lipworth BJ. Comparative adrenal suppression with inhaled budesonide and fluticasone propionate in adult asthmatic patients. Thorax 1996; 51: 262-266.
19. Lipworth BJ. New perspectives on inhaled drug delivery and systemic bioactivity. Thorax 1995; 50: 105-110.
20. Padfield PL, Teelucksingh S. Inhaled corticosteroids: the endocrinologist's view. Eur Respir Rev 1993; 3: 494-500.
21. Law CM, Marchant JL, Honour JW, Preece MA, Warner JO. Nocturnal adrenal suppression in asthmatic children taking inhaled beclomethasone dipropionate. Lancet 1986; i: 942-944.
22. Chervinsky P, Van As A, Bronsky EA, et al. Fluticasone propionate aerosol for the treatment of adults with mild to moderate asthma. J Allergy Clin Immunol 1994; 94: 676-683.
23. Jennings BH, Andersson KE, Johansson SA. Assessment of the systemic effects of inhaled glucocorticosteroids: the influence of blood sampling technique and frequency on plasma cortisol and leucocytes. Eur J Clin Pharmacol 1990; 39: 127-131.
24. Tabachnik E, Zodik Z. Diurnal cortisol secretion during therapy with inhaled beclomethasone dipropionate in children with asthma. J Pediatr 1991; 118: 294-297.
25. Boe J, Bakke P, Rødølen T, Skovlund E, Gulsvik A. High-dose inhaled steroids in asthmatics: moderate efficacy gain and suppression of the hypothalamic-pituitary-adrenal (HPA) axis. Eur Respir J 1994; 7: 2179-2184.
26. Wolthers OD, Pedersen S. Short-term growth during treatment with inhaled fluticasone propionate and beclomethasone dipropionate. Arch Dis Child 1993; 68: 673-676.
27. Ryrfeldt Å, Andersson P, Edsbäcker S, Tönnesson M, Davies D, Pauwels R. Pharmacokinetics and metabolism of budesonide, a selective glucocorticoid. Eur J Respir Dis 1982; 63 (Suppl. 122): 86-95.
28. Thorsson L, Edsbäcker S, Conradson TB. Lung deposition of budesonide from Turbuhaler is twice that from a pressurized metered-dose inhaler pMDI. Eur Respir J 1994; 7: 1839-1844.
29. Mackie AE, Ventresca GP, Moss JA, Bye A. Pharmaco-kinetics of intravenous fluticasone propionate in healthy subjects. Br J Clin Pharmacol 1995; 40: 198P.
30. Dogterom P, Oosterhuis B, Ebels JT, Jonkman JH. Inhaled fluticasone propionate induces greater cortisol suppression compared to budesonide. A dose response study using pressurized metered-dose inhalers (pMDIs). Eur Respir J 1995; 8 (Suppl. 19): 303s.