Design, synthesis and binding properties of novel and selective 5-HT3 and 5-HT4 receptor ligands

European Journal of Medicinal Chemistry

Volumn 35, Issue 12, 2000, Pages 1065-1079

  Modica, Maria ^a   Santagati, Maria ^a   Guccione, Salvatore ^a   Russo, Filippo ^a   Cagnotto, Alfredo ^b   Goegan, Mara ^b   Mennini, Tiziana ^b  

^a UNIVERSITY OF CATANIA   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

5 HT3 and 5 HT4 receptors; Arylpiperazines; Conformational analysis; Ligands

Indexed keywords

2 [4 [4 (2 PYRIMIDINYL) 1 PIPERAZINYL]BUTANOYLAMINO] 4,5 DIMETHYL 3 THIOPHENECARBOXYLIC ACID ETHYL ESTER; 3 AMINO 2 (4 BENZYL 1 PIPERAZINYL) 5,6 DIMETHYLTHIENO[2,3 D]PYRIMIDIN 4(3H) ONE; AMINODIMETHYLTHIOPHENE DERIVATIVE; PIPERAZINE DERIVATIVE; SEROTONIN 3 RECEPTOR; SEROTONIN 4 RECEPTOR; THIENOPYRIMIDOPIPERAZINE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONFORMATION; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; RECEPTOR AFFINITY; STRUCTURE ANALYSIS;

EID: 0034519267     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(00)01187-9     Document Type: Article

References (20)