High affinity and selectivity of [[(arylpiperazinyl)alkyl]thio]thieno[2,3-d]pyrimidinone derivatives for the 5-HT1(A) receptor. Synthesis and structure - Affinity relationships

European Journal of Medicinal Chemistry

Volumn 35, Issue 7-8, 2000, Pages 677-689

  Modica, Maria ^a   Santagati, Maria ^a   Russo, Filippo ^a   Selvaggini, Carlo ^b   Cagnotto, Alfredo ^b   Mennini, Tiziana ^b  

^a UNIVERSITY OF CATANIA   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

5 HT1(A) receptor; Ligands; Thienopyrimidinones

Indexed keywords

3 AMINO 2 [[3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]PROPYL]THIO] 6 ETHYL THIENO[2,3 D]PYRIMIDIN 4(3H) ONE; ALPHA 1 ADRENERGIC RECEPTOR; SEROTONIN 1A RECEPTOR; THIENO[2,3 D]PYRIMIDIN 4 ONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG ACTIVITY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; NONHUMAN; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

EID: 0033914050     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(00)00175-6     Document Type: Article

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